{ "docId": "019dd923-622c-750b-8b9a-101b5bfde4b8", "docSlug": "a70fecd99534", "documentTitle": "Berkeley Lights (BLI)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "research-note", "documentKindLabel": "Research note", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2021-09-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.2941177, "pageNumber": 117, "pageCount": 158, "prevPage": 116, "nextPage": 118, "slideType": "villain_critique", "function": "name_villain", "density": "dense", "nDataPoints": 0, "notes": "The slide uses direct quotes from an expert consultation to frame the instrument as unreliable for high-stakes scientific work.", "elementsJson": [ "headline_text", "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-101b5bfde4b8/117", "deckHref": "/decks/019dd923-622c-750b-8b9a-101b5bfde4b8", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-101b5bfde4b8.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-101b5bfde4b8#slide-117", "components": [ { "bbox": null, "kind": "callout", "text": "Instrument is perceived harshly in the field; “anybody” familiar with single-cell analysis is “very skeptical and rightfully so” particularly for critical applications like FDA submissions; scientists are skeptical that cell assays can “behave normally” in the instrument.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-2042-70a9-a1ad-6085b75e4b23", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.85, "x": 0.08, "y": 0.3 }, "kind": "paragraph", "text": "Machine is perceived harshly; “anybody” familiar with single-cell analysis is “very skeptical and rightfully so” particularly for critical applications such as FDA approvals; only useful for handful of low risk, low value applications", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "0a3650b3-7eb1-4b46-867b-6e7d6bfd7c7d", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.85, "x": 0.08, "y": 0.65 }, "kind": "paragraph", "text": "Scientists are skeptical that cell assays can “behave normally” in the instrument", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "3de3bf08-c453-4ece-87a1-9f9df98f4ca5", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.85, "x": 0.08, "y": 0.39 }, "kind": "quote", "text": "A: “It is perceived harshly. And I think people who are sort of new to the field, they're very excited about it because, I think on the face of it, it can be very flashy and very interesting. I think people who are really well-established in the field of single-cell analysis have a very realistic approach, like, 'Hey, if you've got time and money to burn, and you can make it work for your particular application, that's great.' You'll be able to really at least churn through some experiments, hopefully, demonstrate with some validated data that what you're seeing is pretty realistic. But in terms of why your application or applicability in some of these critical areas, things that require FDA approval, anybody who is familiar with the field tends to be very skeptical, and rightfully so.”", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "5aada98d-069c-41c4-ad2e-636a5bebba4a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.85, "x": 0.08, "y": 0.68 }, "kind": "quote", "text": "Q: “What are the sources of skepticism?“ A: “The sources of skepticism, just as an example, a neuroscientist I work with hates Beacon because he says, “This is the most unnatural assay I think I've ever seen before. You absolutely cannot expect—anybody with a biological background is going to look at that and be like, the cells are going to behave normally.”", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "bc663cd2-5911-4a43-8362-3f44c3eb15aa", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "It is perceived harshly. And I think people who are sort of new to the field, they're very excited about it because, I think on the face of it, it can be very flashy and very interesting. I think people who are really well-established in the field of single-cell analysis have a very realistic approach, like, 'Hey, if you've got time and money to burn, and you can make it work for your particular application, that's great.' You'll be able to really at least churn through some experiments, hopefully, demonstrate with some validated data that what you're seeing is pretty realistic. But in terms of why your application or applicability in some of these critical areas, things that require FDA approval, anybody who is familiar with the field tends to be very skeptical, and rightfully so. — Leading Academic Institution/Ex-BLI Scientist; This is the most unnatural assay I think I've ever seen before. You absolutely cannot expect—anybody with a biological background is going to look at that and be like, the cells are going to behave normally. — Leading Academic Institution/Ex-BLI Scientist", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-2042-70a9-a1ad-67232cfa8f90", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.3, "x": 0.05, "y": 0.96 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "6eae828f-9906-4b62-a125-cc5026265ecb", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.9, "x": 0.05, "y": 0.08 }, "kind": "title", "text": "LEADING ACADEMIC INSTITUTION/EX-BLI SCIENTIST (cont'd): Instrument is perceived harshly in the field; “anybody” familiar with single-cell analysis is “very skeptical and rightfully so” particularly for critical applications like FDA submissions; scientists are skeptical that cell assays can “behave normally” in the instrument.", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "fb9d3843-feff-4a63-bbc3-7b8eb1b71b51", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [ { "to": 150, "from": 42, "beatId": "172d6e2f-be3f-4802-92e5-e7e412ccdabe", "arcName": "Overcoming the Monster", "arcSlug": "overcoming-monster", "beatName": "Testimonials from Customers and Former Employees", "beatSlug": null, "evidence": "The document presents testimonials from customers and former employees, providing first-hand accounts of the challenges and limitations of Berkeley Lights' product.", "position": 2, "confidence": 0.8, "parentBeatName": null, "parentBeatSlug": null } ], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }