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  "documentTitle": "Penumbra, Inc. (PEN)",
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  "authorName": "Spruce Point Capital Management",
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      "kind": "callout",
      "text": "While helping to establish mechanical thrombectomy as the new standard of care for acute ischemic stroke, the MR CLEAN study did much more to justify the use of stent retrievers than it did any other method of intraarterial acute ischemic stroke treatment.",
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      "text": "While both the stent retriever and aspiration catheter won support from – and adoption by – physicians through the 2010s, the stent retriever saw stronger support from early clinical trials. The first randomized controlled trial (RCT) to show superior outcomes among stroke patients treated with mechanical thrombectomy versus the established standard of care was the landmark MR CLEAN study, published Jan 2015.1 While formally providing support for mechanical thrombectomy in general (when used in conjunction with tPA), the study itself focused primarily on stent retrievers, which were used on 190 of the 195 subjects treated with mechanical thrombectomy.1 Just one was treated with thromboaspiration alone.2 With early trials focused on the stent retriever method, this treatment gained traction among neurosurgeons more quickly than did thromboaspiration, leading medical device companies in the space to concentrate their R&D and marketing efforts on stent retrievers.",
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      "kind": "title",
      "text": "Early Clinical Support For Mechanical Thrombectomy Favors Stent Retrievers",
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