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  "documentTitle": "CareDx, Inc. (CDNA)",
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  "authorName": "Kerrisdale Capital",
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  "presentationDate": "2019-07-01 00:00:00",
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  "notes": "The slide uses a box plot to demonstrate the lack of statistical separation between 'No rejection' and 'CMR' groups.",
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      "text": "dd-cfDNA was not able to discriminate TCMR from no rejection... The relatively low sensitivities observed in both studies [i.e., this and the Bloom study referenced above] indicate that the dd-cfDNA test is susceptible to false negative results.",
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      "text": "Box plot showing dd-cfDNA levels across four biopsy diagnosis categories.",
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      "text": "On AMR, the paper concluded that “dd-cfDNA more reliably discriminated AMR and we consider that its greatest applicability will likely be for discerning the presence of AMR...”",
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      "text": "On TCMR, the paper concluded that: dd-cfDNA was not able to discriminate TCMR from no rejection... levels of dd-cfDNA are not consistent across rejection types and levels observed in cases of isolated CMR can be indistinguishable from those without rejection.",
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      "kind": "paragraph",
      "text": "Finally, on the topic of subclinical rejection, the paper admits that: dd-cfDNA was primarily assessed on a “for-cause” basis... It is not yet known whether the prediction characteristics for dd-cfDNA will be similar when used to predict subclinical rejection.",
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      "text": "dd-cfDNA was not able to discriminate TCMR from no rejection... The relatively low sensitivities observed in both studies [i.e., this and the Bloom study referenced above] indicate that the dd-cfDNA test is susceptible to false negative results, particularly among cases of CMR... levels of dd-cfDNA are not consistent across rejection types and levels observed in cases of isolated CMR can be indistinguishable from those without rejection. — Huang et al.",
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      "text": "Source: Huang et al.",
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      "text": "Distribution of Donor-Derived Cell-Free DNA Percentage by Biopsy Diagnosis",
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