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      "text": "Almost all of SONAR’s positive conclusions are based on or inflated by measurements of creatinine, apparently due to the expense and difficulty of using more accurate biomarkers at scale.",
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      "text": "advancement to end-stage kidney disease converged temporarily late in the SONAR trial, precisely when, if atrasentan had a positive effect on kidney disease, we should expect to see the largest difference because of accumulating drug effects.",
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      "text": "We wonder whether this convergence in rates of end-stage renal disease between groups, along with the elevated risk of cardiovascular complication elaborated infra, is the real reason for the abrupt abandonment of the SONAR trial. — Muddy Waters Research",
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