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  "documentTitle": "Chinook Therapeutics Inc (KDNY)",
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  "notes": "The slide argues that the drug Atrasentan acts as a 'band-aid' by masking symptoms via surrogate endpoints without providing long-term structural benefit.",
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      "text": "This “snap-back” suggests that no cumulative renal repair is taking place.",
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      "text": "The UACR graph from the SONAR study is reproduced in the 2021 Chinook 10-K, and we see the exact same results: a temporary, abrupt change in UACR, consistent with a hemodynamic effect, followed by an abrupt change back to baseline.",
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      "text": "Atrasentan is, in our view, a band-aid, for which no evidence exists of structural benefit in any kidney disease. It covers up patient decline by interfering with surrogate endpoints, but at the end of the day, the disease is still doing its work.",
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      "text": "52 2021 Chinook 10-K, Pg. 14. 53 https://repo.dma.dp.ua/6035/1/SONAR.pdf. 54 https://repo.dma.dp.ua/6035/1/SONAR.pdf, see Appendix.",
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      "text": "Some Metrics Converge While the Trial is Still Ongoing",
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