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      "text": "Recommendations are available in the literature on how to design trials, analyze resultant data, and report findings when composite endpoints are to be used. The main recommendations include that (i) individual components should have similar frequency of occurrence, (ii) the treatment should have a similar effect on all components, (iii) individual components should have similar importance to patients, (iv) data from all components should be collected until the end of trial, and (v) individual components should be analyzed and reported separately as secondary endpoints... We argue that the",
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      "text": "136 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923692/ 137 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923692/",
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      "text": "Table 2: Effects of atrasentan on renal and cardiovascular outcomes",
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