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  "documentTitle": "Chinook Therapeutics Inc (KDNY)",
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  "authorName": "Carson C. Block",
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  "notes": "The slide critiques the visual representation of clinical trial data, specifically the 'time-distorting' nature of the x-axis in the provided graph.",
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      "text": "The time since randomization—that is, most of the important content of the graph—uses six-month time increments. This allows AbbVie to plot a reasonable looking slope: BNP, and consequently risk of heart failure, increases over time in both groups while always remaining higher in the drug group, but the change seemingly doesn’t happen at too great a rate.",
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      "text": "The graphs display another unusual feature we have not yet discussed: they are time-distorting. Take the graph of BNP as an example.",
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      "text": "But what about the enrichment period? The enrichment period is six weeks long, meaning that, in order to give an accurate sense of the change in BNP during the enrichment period, the space devoted to it in the graph should be about",
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      "text": "A number of distressing artifacts appear when we follow through to the end of the treatment period: (1) all differences in systolic blood pressure between the treatment and the placebo group disappear...",
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      "text": "heart failure risk—only about half of the original responder population’s data for 24 months into the study has been published. There are similar declines in measurement of systolic blood pressure, UACR, and body weight...",
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      "text": "130 See Appendix. 131 We have reason to think this is also an underestimate of the real difference. Discussed later in this report, re: anemia and blood dilution. 132 See Appendix.",
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