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  "documentTitle": "Chinook Therapeutics Inc (KDNY)",
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      "text": "There were no meaningful changes in blood pressure and acute eGFR, suggesting proteinuria reductions were not primarily due to hemodynamic effects of atrasentan",
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      "text": "Phase II study (n=20); 70% had baseline proteinuria >1g/day. Atrasentan reduced proteinuria at weeks 6, 12, 24. No BP/eGFR changes. Well-tolerated, no SAEs. No BNP/weight increase.",
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      "text": "Discussion of anemia events in SONAR (18% vs 10% placebo) and the clinical significance of anemia as a risk factor for mortality in IgAN patients.",
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      "text": "Over time, anemia events were reported in approximately 18 percent of atrasentan patients compared with ten percent of placebo treated patients, with mean change in hemoglobin between groups of approximately one g/dL; these findings are consistent with mechanism-based hemodilution. — Chinook Therapeutics 2021 10-K",
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      "text": "Citations 105-108 provided at the bottom.",
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