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  "documentTitle": "Chinook Therapeutics Inc (KDNY)",
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  "authorName": "Carson C. Block",
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  "notes": "The slide uses a table to highlight inconsistent reporting of Acute Kidney Injury (AKI) across different study groups and provides a narrative critique of cardiac failure reporting.",
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      "text": "Why is this? Only the SONAR authors can say for sure, but we believe the likeliest explanation is a systematic attempt to misrepresent the data to make them appear more favorable to atrasentan than they are.",
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      "text": "In the non-responder group, fluid retention, anemia, and heart failure were both more common among atrasentan patients than placebo patients.",
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      "text": "The observed renal benefit depends on questionable metrics to appear statistically significant, and AKI, another important indicator of renal health, has been reported in three different locations with three entirely different sets of numbers.",
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      "text": "Cardiac Failures: Atrasentan induced more cardiac failures than it prevented advancements to ESKD in the SONAR trial, with a numerical difference of at least 21 in cardiac events.",
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      "text": "The Enrichment Atrasentan group, as we discuss infra, is noted nowhere as a distinct adverse-event suffering population in the main body of the SONAR study or its appendix.",
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      "text": "Citations 90-94 referencing SONAR study documents and supplementary appendices.",
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