{
  "docId": "019dd923-622c-750b-8b97-5cb48bf2a635",
  "docSlug": "b8afd3741673",
  "documentTitle": "Chinook Therapeutics Inc (KDNY)",
  "authorId": "51_Muddy_Waters",
  "authorName": "Carson C. Block",
  "documentKindSlug": "research-note",
  "documentKindLabel": "Research note",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2023-05-16 00:00:00",
  "orientation": "portrait",
  "aspectRatio": 0.77272725,
  "pageNumber": 15,
  "pageCount": 36,
  "prevPage": 14,
  "nextPage": 16,
  "slideType": "appendix_data",
  "function": "expose_contradiction",
  "density": "dense",
  "nDataPoints": 60,
  "notes": "The text explicitly alleges data tampering regarding Acute Kidney Injury (AKI) reporting in the SONAR study.",
  "elementsJson": [
    "data_table",
    "paragraph",
    "footnote"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b97-5cb48bf2a635/15",
  "deckHref": "/decks/019dd923-622c-750b-8b97-5cb48bf2a635",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b97-5cb48bf2a635.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b97-5cb48bf2a635#slide-15",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "The distinction goes from arbitrary to outright suspicious when comparing numbers given in the Supplementary Appendix to the SONAR study to the numbers that appear in the FDA-reported adverse effects table.",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-25b7-709e-b8d0-972a61087f8f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": null,
      "kind": "metric",
      "text": "Acute kidney injury: 32",
      "attrs": null,
      "subkind": "primary",
      "toolName": "Quantification",
      "toolSlug": "quantification",
      "confidence": null,
      "componentId": "019dd953-25b7-709e-b8d0-9a7b96eab963",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.76,
        "x": 0.12,
        "y": 0.5
      },
      "kind": "paragraph",
      "text": "These numbers seem at first unremarkable. But there are multiple clear discrepancies between the reported numbers in the Supplementary Appendix, Table 3 supra, and the FDA-reported AKI numbers.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4a016288-04ec-461a-9799-87264afa1406",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.76,
        "x": 0.12,
        "y": 0.795
      },
      "kind": "paragraph",
      "text": "Even in the responder population, the number of AKI events reported is higher than in the main body of the paper. In the non-responder population, the difference in AKI was much larger.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "82fc60c0-2903-4ceb-98c7-36b4ea068386",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.76,
        "x": 0.12,
        "y": 0.655
      },
      "kind": "paragraph",
      "text": "Table 3 in the main body of the SONAR study analysis gives 32 cases of AKI in atrasentan patients and 28 in placebo patients... The distinction goes from arbitrary to outright suspicious when comparing numbers.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b0ef721f-003b-4fac-951c-314634d961c0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.3,
        "x": 0.12,
        "y": 0.92
      },
      "kind": "source-note",
      "text": "86 https://repo.dma.dp.ua/6035/1/SONAR.pdf, Table 3.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "49c0c1da-3a35-422b-9857-8147ffa90029",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.5,
        "x": 0.25,
        "y": 0.095
      },
      "kind": "table",
      "text": "Table showing adverse events for Atrasentan (n=1321) vs Placebo (n=1320) with p-values.",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "fd9b689c-f41e-492a-9e8e-345fec7aa38e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.5,
        "x": 0.25,
        "y": 0.463
      },
      "kind": "title",
      "text": "Table 3: Adverse events during double-blind treatment period",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4a49200a-7fcd-4f4a-8d46-17b1f5500477",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 15,
      "from": 6,
      "beatId": "7c7d9806-d739-4215-b62f-052b350305ec",
      "arcName": "Overcoming the Monster",
      "arcSlug": "overcoming-monster",
      "beatName": "The Struggle",
      "beatSlug": "overcoming-monster-the-struggle",
      "evidence": "The report presents the 'struggle' of analyzing the data and identifying issues",
      "position": 1,
      "confidence": 0.8,
      "parentBeatName": "Development",
      "parentBeatSlug": "development"
    }
  ],
  "loops": [
    {
      "to": 15,
      "from": 6,
      "name": "Pattern Hunter",
      "slug": "02-pattern-hunter",
      "bestFor": "Time-pressed audiences, building consensus, when data is strong",
      "matchId": "437b3fa7-133f-4a21-908b-7e42915fbdb3",
      "evidence": "The report presents a series of data analyses that reveal inconsistencies",
      "position": 0,
      "objective": "To identify patterns in the data that suggest issues with the trial results",
      "structure": "Evidence A -> Evidence B -> Evidence C -> Pattern/Conclusion",
      "confidence": 0.7,
      "description": "Group multiple pieces of evidence that together point to a pattern or conclusion"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}