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      "text": "The SONAR authors have omitted some important indicators of renal health from their primary renal outcome.",
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      "text": "The SONAR authors have omitted some important indicators of renal health from their primary renal outcome. Acute kidney injury (AKI)... is not included in the primary renal endpoint.",
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      "text": "In the enrichment period, patients didn't have time to accumulate progressive cardiovascular damage associated with atrasentan. This implies that the hemodynamic effects that cause cardiac failure are apparent almost immediately...",
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      "text": "drug group. Given that events are expected to rise at a geometric, not linear rate, over time, this quick calculation likely underestimates the rate of mortality in this population had the trial continued...",
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      "text": "One expert told us that anemia was observed across age groups in trials of endothelin receptor antagonists, meaning that IgAN patients would also likely suffer declines in hemoglobin. — Anonymous expert involved in SONAR trial",
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      "text": "83 Call with anonymous expert involved in SONAR trial. 84 https://clinicaltrials.gov/ct2/show/results/NCT01858532?term=atrasentan&draw=2&rank=4 85 https://repo.dma.dp.ua/6035/1/SONAR.pdf, Table 3.",
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