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  "documentTitle": "Prothena Corp PLC (PRTA)",
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  "authorName": "Carson C. Block",
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  "notes": "The slide uses a baseball analogy (Mark Whiten) to illustrate the flaw in 'Best Response' metrics.",
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      "text": "The NEO001 “Best Response Analysis” is misleading in our view as to efficacy, and we further believe it has led to undue optimism about the drug.",
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      "text": "Response Rate: 64.3%",
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      "text": "The NEO001 “Best Response Analysis” is misleading in our view as to efficacy, and we further believe it has led to undue optimism about the drug. The below slide shows a “Best Response Analysis” for NEOD001, and appears to show 47% of the patients were stable, and 53% responded. We view this presentation of data as questionable with regard to establishing efficacy.",
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      "text": "First, this presentation measures the largest biomarker improvement (if any) a patient had during the trial – in our view, it does not establish that the patient’s biomarkers consistently improved, nor that the patient had a positive overall outcome. The corollary to this issue is that it is showing changes in NT-proBNP levels, and as we discuss infra, NT-proBNP can change substantially from day-to-day for these patients due various factors. We think of the Best Response Analysis as akin to extrapolating that former Major League Baseball journeyman Mark Whiten should be inducted into the Hall of Fame based on the one game in which he hit four home runs and 12 RBIs. To help investors gauge efficacy, PRTA should release NT-proBNP levels for each patient in the cohort over the life of the study.",
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      "text": "One possible explanation for the apparent lack of correlation is that enrolled patients had multifactorial congestive heart failure. If this is the case, it points again to weaknesses in the trial data in terms of establishing efficacy.",
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      "text": "We think of the Best Response Analysis as akin to extrapolating that former Major League Baseball journeyman Mark Whiten should be inducted into the Hall of Fame based on the one game in which he hit four home runs and 12 RBIs.",
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      "kind": "title",
      "text": "Depth of Patients’ Last HR Did Not Impact NEOD001 Organ Response",
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