{
  "docId": "019dd923-5fed-74f2-a96f-364382cb2b75",
  "docSlug": "bi-dc35af3bd0eea4cf",
  "documentTitle": "HMNC Brain Health pitch deck: $14 million for precision treatments",
  "authorId": "Pitchdecks",
  "authorName": "HMNC Brain Health",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "strategy_consulting",
  "sourceTypeLabel": "Strategy consulting",
  "presentationDate": null,
  "orientation": "landscape",
  "aspectRatio": 1.777,
  "pageNumber": 9,
  "pageCount": 12,
  "prevPage": 8,
  "nextPage": 10,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "overcrowded",
  "nDataPoints": 2,
  "notes": "Uses a 'Problem-Impasse-Breakthrough' narrative structure.",
  "elementsJson": [
    "headline_text",
    "process_diagram",
    "callout_box"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-5fed-74f2-a96f-364382cb2b75/9",
  "deckHref": "/decks/019dd923-5fed-74f2-a96f-364382cb2b75",
  "deckJsonHref": "/decks/019dd923-5fed-74f2-a96f-364382cb2b75.json",
  "deckAnchorHref": "/decks/019dd923-5fed-74f2-a96f-364382cb2b75#slide-9",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "Our V1bCDx and CRHR1CDx have the potential to identify these patients with high specificity and sensitivity.",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd952-cb16-77cb-9962-e4eb0b1b3d54",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.7,
        "w": 0.55,
        "x": 0.03,
        "y": 0.0018
      },
      "kind": "image",
      "text": "Brain anatomy diagram showing HPA axis and behavioral circuits",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ba20e5f0-f341-4adc-b9e5-70f9c2fda107",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.32,
        "x": 0.65,
        "y": 0.66
      },
      "kind": "list",
      "text": "BREAKTHROUGH: Our V1bCDx and CRHR1CDx have the potential to identify these patients with high specificity and sensitivity. Our pipeline antidepressants BH200 and E2009 are expected to be highly efficacious in CDx-positive patients.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "724ef93b-828d-4940-bcfc-b54937f15db2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.32,
        "x": 0.65,
        "y": 0.42
      },
      "kind": "list",
      "text": "IMPASSE: Developmental programs that targeted the HPA axis were conducted in non-selected patient populations, thereby showed limited efficacy, hence were abandoned.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "74c70023-9aab-4a0f-8ae9-8aed5745612f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.32,
        "x": 0.65,
        "y": 0.18
      },
      "kind": "list",
      "text": "PROBLEM: A substantial subset (~30%, ~100M worldwide) of all patients with MDD have a disturbance in vasopressin and/or CRH signaling, both key regulators of the stress response.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ad11a555-5f90-4e6a-8d9d-1087e1755e8e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.55,
        "x": 0.03,
        "y": 0.94
      },
      "kind": "source-note",
      "text": "Plus sign indicates stimulation, minus sign indicates Inhibition, light blue-shaded brain areas contain CRHR1 and/or V1BR. Abbreviations: ACC, anterior cingulate cortex; ACTH, corticotropin; AM, amygdala; CRH, corticotropin-releasing hormone; PFC, prefrontal cortex; NC, neocortex.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1c0ed652-21d6-4db4-9cfb-aed4f8033d3c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.03,
        "y": 0.04
      },
      "kind": "title",
      "text": "TARGETING STRESS SYSTEM-RELATED DEPRESSION",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4a3e70a7-cc9e-4236-ac32-70eabe40f014",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "before-after-bridge",
      "slug": null,
      "matchId": "62670d97-75f5-4602-ab29-456700f9c603",
      "evidence": "Uses a Problem-Impasse-Breakthrough structure to bridge the gap between clinical failure and new solution.",
      "confidence": 0.8
    }
  ],
  "arcBeats": [],
  "loops": [
    {
      "to": 10,
      "from": 4,
      "name": "Cost Of Inaction",
      "slug": "27-cost-of-inaction",
      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "723e4b79-0471-4e54-9684-ccd3140a0b94",
      "evidence": "Problem statement and traction",
      "position": 0,
      "objective": "Highlighting the cost of not adopting precision psychiatry",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.6,
      "description": "Quantify what happens if the audience does nothing"
    },
    {
      "to": 10,
      "from": 8,
      "name": "Why Now",
      "slug": "15-why-now",
      "bestFor": "Sales pitches, fundraising, requesting immediate budget approval",
      "matchId": "77608a65-a053-4cbb-bd44-0999621d3ce8",
      "evidence": "Co-development pipeline and traction",
      "position": 1,
      "objective": "Explaining the timeliness of the investment opportunity",
      "structure": "The Context (Trends) -> The Trigger Event -> The Window of Opportunity",
      "confidence": 0.6,
      "description": "Create temporal urgency by proving that the window of opportunity is opening or closing"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}