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      "text": "Their approach resulted in protein designs that had ~400 fold greater potency and a ~100 fold increase in protease stability in comparison to molecules designed by traditional methods.",
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      "text": "First, potency and stability were modeled and these models were used to navigate through different protein variants towards improved designs.\nA simulation based on empirical measurements of all single mutation variants of the protein and assuming a linear sequence-to-function relationship finds significant improvements to both potency and stability. Both graphs represent the same pool of molecules.",
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      "text": "Treatments for inflammatory bowel diseases such as Crohn’s Disease and Ulcerative Colitis need not only inhibit inflammation, but must also survive while travelling through the gut. In order to achieve this, LabGenius simultaneously co-optimised potency and stability in the presence of protease. Their approach resulted in protein designs that had ~400 fold greater potency and a ~100 fold increase in protease stability in comparison to molecules designed by traditional methods.",
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