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  "documentTitle": "Vaccines & Therapeutics Outlook Part I: Timelines and Success Factors",
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  "authorName": "BCG",
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  "notes": "The slide uses a three-column layout to compare key metrics for vaccine success.",
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      "kind": "list",
      "text": "Safety: Limited data; acceptable profile; few grade 3 adverse reactions; Phase 3 trials awaited; traditional paradigm takes 5-10+ years.",
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      "text": "Duration of immunity: Limited data; 3 months observed; WHO prefers 1 year; leading vaccines 1-2 years; positive t-cell response evidence.",
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      "text": "Efficacy: Validation data limited; WHO prefers 70%+; FDA recommends 50%+; sub-group data limited; comparable to influenza (40-60%).",
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      "text": "1. The potential of a drug/vaccine to protect from a disease in controlled clinical trials; 2. WHO target profile minimum efficacy expectation is 50%+; 3. Sub-groups like children, pregnant women, elderly, etc; 4. Severe or medically significant but not immediately life- threatening; 5. WHO target profile minimum duration expectation is 6 months; 6. Russia's recently registered vaccine, Sputnik V, claims to provide immunity for up to 2 years; Source: WHO, BBC, Science Magazine, Bloomberg, Livemint, FiercePharma, BCG",
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      "kind": "title",
      "text": "Approval authorization and broader distribution driven by three key factors",
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      "text": "Vaccine key success factors | Approval authorization and broader distribution driven by three key factors",
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