{
  "schemaVersion": "deck-intelligence.v1",
  "id": "019de073-ce1e-74cc-9870-b1827d8467a5",
  "slug": "ce894072ac0bdbdb4be0c6e520599e56",
  "title": "Nuvalent | Investor Presentation Deck | 31 slides",
  "subtitle": "Nuvalent · 2022-10",
  "author": "Nuvalent",
  "date": "2022-10-01 00:00:00",
  "pageCount": 31,
  "kind": "conference-presentation",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "document": {
    "id": "019de073-ce1e-74cc-9870-b1827d8467a5",
    "slug": "ce894072ac0bdbdb4be0c6e520599e56",
    "title": "Nuvalent | Investor Presentation Deck | 31 slides",
    "rawTitle": "Nuvalent | Investor Presentation Deck | 31 slides",
    "authorId": "nuvalent",
    "authorName": "Nuvalent",
    "authorDisplay": "Nuvalent",
    "kind": {
      "slug": "conference-presentation",
      "label": "Conference presentation"
    },
    "sourceType": {
      "slug": "investor_relations",
      "label": "Investor relations"
    },
    "fileName": "2022-10__nuvalent__investor-pres__ce894072.pdf",
    "sourceUrl": "https://www.slidebook.io/company/nuvalent/presentation/ce894072ac0bdbdb4be0c6e520599e56/",
    "sourceDate": "2022-10-28 00:00:00",
    "presentationDate": "2022-10-01 00:00:00",
    "ingestedAt": "2026-04-30 22:12:59.140149+00",
    "status": "ready",
    "pageCount": 31,
    "orientation": "landscape",
    "aspectRatio": 1.7777778,
    "targetCompany": null,
    "targetTicker": null,
    "metadata": {
      "corpus": "slidebook",
      "industry": "biotechnology",
      "local_root": "/Users/miguelsuredasuau/Desktop/lalalalla/_scrape/slidebook/decks/2022-10__nuvalent__investor-pres__ce894072",
      "image_width": 1920,
      "image_format": "jpg",
      "deck_type_raw": "Investor Presentation Deck",
      "deck_type_slug": null,
      "source_url_pattern": "https://www.slidebook.io/company/{company_slug}/presentation/{deck_id}/"
    }
  },
  "coverage": {
    "pageCount": 31,
    "pagesIndexed": 31,
    "pagesWithImages": 31,
    "pagesWithMetadata": 31,
    "imageCoveragePct": 100,
    "metadataCoveragePct": 100,
    "componentCount": 143,
    "chartCount": 18,
    "metricSlides": 0,
    "toolMatches": 21,
    "documentToolMatches": 0,
    "frameworkMatches": 5,
    "arcMatches": 1,
    "beatMatches": 3,
    "loopMatches": 1,
    "patternMatches": 0,
    "storymakersMatch": false,
    "scoreAvailable": false,
    "reviewAvailable": false,
    "activistThesisAvailable": false,
    "pitchdeckMetadataAvailable": false,
    "pitchdeckProfileAvailable": false
  },
  "blocks": [],
  "matches": {
    "arcs": [
      {
        "arc": {
          "name": "The Sequoia Pitch",
          "slug": "sequoia-pitch",
          "status": "active",
          "bestFor": "Investor pitches, Series A/B, board presentations",
          "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
        "evidence": "The presentation deck follows a similar structure to the Sequoia Pitch, with sections on problem, solution, market size, and team.",
        "isPrimary": true,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-16 22:27:27.84396+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": "doc-narrative-v1"
        }
      }
    ],
    "beats": [
      {
        "to": 6,
        "arc": {
          "name": "The Sequoia Pitch",
          "slug": "sequoia-pitch",
          "status": "active",
          "bestFor": "Investor pitches, Series A/B, board presentations",
          "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "from": 6,
        "name": "Problem",
        "beatId": "645eb1af-3b23-4bf3-bf6c-a731c328939a",
        "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
        "beatType": {
          "name": "Problem",
          "slug": "sequoia-pitch-problem",
          "status": "active",
          "canonId": "019dd9b8-1ed4-767b-8e05-40e733bd2311",
          "version": 1,
          "description": null
        },
        "evidence": "Slide 6: Overcoming Kinase Selectivity in NSCLC",
        "position": 0,
        "isPrimaryArc": true,
        "parentBeatType": {
          "name": "Complication",
          "slug": "complication",
          "status": "active",
          "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
          "version": 1,
          "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
        },
        "alignedBlockIds": null,
        "matchConfidence": 0.8
      },
      {
        "to": 7,
        "arc": {
          "name": "The Sequoia Pitch",
          "slug": "sequoia-pitch",
          "status": "active",
          "bestFor": "Investor pitches, Series A/B, board presentations",
          "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "from": 7,
        "name": "Solution",
        "beatId": "6c9c65e6-1206-45c3-bfc7-f5e5a5a7b47d",
        "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
        "beatType": {
          "name": "Solution",
          "slug": "sequoia-pitch-solution",
          "status": "active",
          "canonId": "019dd9b8-1fb1-71d9-a260-07738d7f9c2f",
          "version": 1,
          "description": null
        },
        "evidence": "Slide 7: NVL-520 for ROS1-Positive Advanced NSCLC and other Solid Tumors",
        "position": 1,
        "isPrimaryArc": true,
        "parentBeatType": {
          "name": "Turn",
          "slug": "turn",
          "status": "active",
          "canonId": "019dd9b8-0396-702b-ac2f-9901f8dd8b54",
          "version": 1,
          "description": "The pivot — solution proposed, catalyst introduced, decision made. Common (15/20 arcs) but not universal: Triple-take, AIDA, PAS, Voyage-return and Pixar substitute it with a strong reflection or development beat."
        },
        "alignedBlockIds": null,
        "matchConfidence": 0.8
      },
      {
        "to": 24,
        "arc": {
          "name": "The Sequoia Pitch",
          "slug": "sequoia-pitch",
          "status": "active",
          "bestFor": "Investor pitches, Series A/B, board presentations",
          "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "from": 24,
        "name": "Market Size",
        "beatId": "fb539b55-6d05-405d-8cdc-98ff53e69b9f",
        "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
        "beatType": {
          "name": "Market Size",
          "slug": "sequoia-pitch-market-size",
          "status": "active",
          "canonId": "019dd9b8-20e6-729c-bc28-05442906d032",
          "version": 1,
          "description": null
        },
        "evidence": "Slide 24: Nuvalent Pipeline – Ongoing Programs",
        "position": 2,
        "isPrimaryArc": true,
        "parentBeatType": {
          "name": "Evidence",
          "slug": "evidence",
          "status": "active",
          "canonId": "019dd9b8-03f9-772a-b84a-4f07b415b77a",
          "version": 1,
          "description": "A dedicated proof beat exists in only ~4 arcs (Gambit, Sequoia, AIDA, Monroes). Other arcs embed evidence inline within development."
        },
        "alignedBlockIds": null,
        "matchConfidence": 0.8
      }
    ],
    "loops": [
      {
        "to": 16,
        "from": 6,
        "loop": {
          "name": "27_cost_of_inaction",
          "slug": "27-cost-of-inaction",
          "status": "active",
          "bestFor": "Urgent budget requests, compliance, risk mitigation",
          "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
          "version": 1,
          "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
          "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
          "description": "Quantify what happens if the audience does nothing",
          "familyLabel": null,
          "categoryName": "Urgency",
          "categorySlug": "urgency"
        },
        "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
        "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
        "position": 0,
        "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-16 22:27:28.003066+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": "doc-narrative-v1"
        }
      }
    ],
    "tools": [
      {
        "tool": {
          "name": "Slide recipe: Cover",
          "slug": "cover-slide",
          "status": "active",
          "bestFor": null,
          "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
          "version": 1,
          "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
          "description": "The first ten seconds. Build it deliberately.",
          "familyLabel": "slide-recipe",
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "designer",
        "layer": "slide",
        "agents": [
          "designer"
        ],
        "matchId": "aee04abc-84c5-4aff-9386-a7dfef288d9e",
        "evidence": "This is a cover slide with a title, headline, and logo.",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:13:28.940045+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 1,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Slide recipe: Cover",
          "slug": "cover-slide",
          "status": "active",
          "bestFor": null,
          "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
          "version": 1,
          "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
          "description": "The first ten seconds. Build it deliberately.",
          "familyLabel": "slide-recipe",
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "designer",
        "layer": "slide",
        "agents": [
          "designer"
        ],
        "matchId": "5c4c319c-1b15-46c5-b6a4-2ce4ef8a01ab",
        "evidence": "This is a cover slide with a title, subtitle, and image.",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:13:29.102955+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 4,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Slide recipe: Cover",
          "slug": "cover-slide",
          "status": "active",
          "bestFor": null,
          "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
          "version": 1,
          "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
          "description": "The first ten seconds. Build it deliberately.",
          "familyLabel": "slide-recipe",
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "designer",
        "layer": "slide",
        "agents": [
          "designer"
        ],
        "matchId": "b99f940b-b2c0-42a2-8ce0-de55cb0d0f7f",
        "evidence": "This is a cover slide with a title, headline, and logo.",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:13:29.38585+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 10,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chartjunk Elimination",
          "slug": "chartjunk-elimination",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b49e-7453-ab01-b60f338eeda1",
          "version": 1,
          "bodyDocId": null,
          "description": "Remove decorative elements that don't convey data: 3D effects, shadows, unnecessary gridlines",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "598f5a11-61e4-44ed-bf55-23b40b50634b",
        "evidence": "chart/line: Pharmacokinetic concentration over time for 25, 50, 75, and 100 mg QD cohorts",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 03:36:36.007415+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 15,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Waterfall chart",
          "slug": "waterfall-chart",
          "status": "active",
          "bestFor": null,
          "canonId": "e2799da3-725f-44a9-a093-570f1f388e64",
          "version": 1,
          "bodyDocId": null,
          "description": null,
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "95860f3c-9539-41b8-b7ad-966ce9a045a6",
        "evidence": "chart/waterfall: Waterfall plot of best % change in target lesions",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 03:36:36.145053+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 17,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Before/after framing",
          "slug": "before-after-framing",
          "status": "active",
          "bestFor": "For turnaround / reform proposals",
          "canonId": "019dd9e1-528b-72ec-a563-e5dcb9410f67",
          "version": 1,
          "bodyDocId": "019dd9a1-80bf-72e9-980b-ccd1c0cd3488",
          "description": "You visualise two futures side by side: the trajectory the target is on\ntoday, and the trajectory under your proposed intervention. The reader\nhas to see the delta to feel the stakes.\n\nIt's the rhetorical cousin of the peer-gap — same visual grammar\n(comparison), but across **time** instead of across peers.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "90d9847d-73c0-4d96-9f88-0ab606ae9820",
        "evidence": "chart/line: Reduction in Tumor Burden in Cancers with ROS1 G2032R",
        "pageRefs": null,
        "priority": null,
        "whenToUse": "For turnaround / reform proposals",
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 03:36:36.27533+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 19,
        "whyItWorks": "- It **quantifies the opportunity cost** of inaction. \"Doing nothing\"\n  becomes a concrete, visible path, not an abstraction.\n- It **makes the Answer tangible**. The prescription isn't a paragraph;\n  it's a trajectory the reader can point at.\n- It **pre-empts the status-quo defence**. Management usually argues \"we\n  have a plan\". Your chart shows what their plan looks like vs. yours.\n- It **satisfies both the Architect** (math adds up) **and the Storyteller**\n  (emotional delta between two futures).",
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Before-After-Bridge",
          "slug": "before-after-bridge",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-8604-7188-883f-42370288ad05",
          "version": 1,
          "bodyDocId": null,
          "description": "Narrative structure: Paint the before, show the after, explain the bridge",
          "familyLabel": null,
          "categoryName": "Block",
          "categorySlug": "block"
        },
        "agent": "Storyteller",
        "layer": "slide",
        "agents": [
          "Storyteller"
        ],
        "matchId": "4368b258-701c-40c8-af56-5f3378f823a7",
        "evidence": "image/photo: MRI scans at Baseline, 4 weeks, and 8 weeks",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 03:36:36.359151+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 20,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Before-After-Bridge",
          "slug": "before-after-bridge",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-8604-7188-883f-42370288ad05",
          "version": 1,
          "bodyDocId": null,
          "description": "Narrative structure: Paint the before, show the after, explain the bridge",
          "familyLabel": null,
          "categoryName": "Block",
          "categorySlug": "block"
        },
        "agent": "Storyteller",
        "layer": "slide",
        "agents": [
          "Storyteller"
        ],
        "matchId": "0586663b-5808-4238-bace-816990f50784",
        "evidence": "The slide shows a before-after comparison with CT and MRI scans at Baseline, 4 weeks, and 16 weeks.",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-17 03:36:29.139629+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 21,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Table data",
          "slug": "table-data",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4fab-7168-a82f-b847350a006d",
          "version": 1,
          "bodyDocId": null,
          "description": "Tabular layouts of structured data.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "c73ad32f-4f3a-446b-bdc8-8f8ee8c88c0a",
        "evidence": "Pipeline table with columns for Indication, Candidate, Mutations, Phases, Milestones, and Rights",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:13:51.843241+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 24,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "List presentation",
          "slug": "list-presentation",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
          "version": 1,
          "bodyDocId": null,
          "description": "Bulleted, numbered, or checklist enumerations.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "b1c06be6-3b8c-44f8-9542-40bc8229e8bb",
        "evidence": "list/bullet: Active against treatment-emergent ALK G1202R single and compound resistance mutations e.g., G1202R/L1196M, G1202R/G1269A, G1202R/L1198F",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-17 00:13:51.914596+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 25,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "861177a9-2a41-4b2b-a260-8041180323c3",
        "evidence": "chart/scatter: Activity against ALK wild-type and mutants",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:51.985214+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 26,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "e6b592c3-4631-4cb8-82ca-fe9dcabce9a6",
        "evidence": "chart/bar-grouped: Avoiding TRK inhibition",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.019939+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 26,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "0191297e-1812-4c15-b64d-f936259da331",
        "evidence": "chart/bar-vertical: Brain penetrance",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.055038+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 26,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "16f9f379-c123-41d9-8af0-2f15fa39e825",
        "evidence": "chart/bar-grouped: Change in tumor size (%) across various models for Vehicle vs NVL-655",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.126179+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 27,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "cdd37823-488b-4d77-84d1-5891f677ab58",
        "evidence": "chart/line: Tumor volume (mm3) over days on treatment for PDX model",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.161007+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 27,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Table data",
          "slug": "table-data",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4fab-7168-a82f-b847350a006d",
          "version": 1,
          "bodyDocId": null,
          "description": "Tabular layouts of structured data.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "4f78bb96-c029-4898-b367-d6cc303e04e1",
        "evidence": "table/data: Phase 1 and Phase 2 cohort definitions including tumor type, prior TKI, and prior chemo lines",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:13:52.230701+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 28,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "List presentation",
          "slug": "list-presentation",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
          "version": 1,
          "bodyDocId": null,
          "description": "Bulleted, numbered, or checklist enumerations.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "d38b12e1-42f6-438e-a6d8-f005c45aa77c",
        "evidence": "list/bullet: Brain penetrant. ~20% of patients with HER2-positive NSCLC present with brain metastases",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-17 00:13:52.300063+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 29,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "bfab4e5e-bb73-4f97-af91-21c76f0d5795",
        "evidence": "chart/dot: In vitro activity, HER2 and HER2ex20",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.371048+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 30,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "2c4c0c1e-c150-4077-823d-aa1cd5be85c7",
        "evidence": "chart/bar-vertical: Avoiding EGFR inhibition",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.406118+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 30,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Chart Selection Guide",
          "slug": "chart-selection-guide",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
          "version": 1,
          "bodyDocId": null,
          "description": "Choosing the right chart type for your data and message",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Designer",
        "layer": "slide",
        "agents": [
          "Designer"
        ],
        "matchId": "8d555d63-06a5-435f-ae04-2803af6a89ba",
        "evidence": "chart/bar-vertical: Brain penetrance",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-17 00:13:52.440706+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 30,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "List presentation",
          "slug": "list-presentation",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
          "version": 1,
          "bodyDocId": null,
          "description": "Bulleted, numbered, or checklist enumerations.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "780be429-fee1-4d20-900b-b2bc55a88afc",
        "evidence": "list/bullet: Innovative molecular structures with the potential to overcome the dual challenges of kinase resistance and selectivity in the CNS and in the periphery",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-17 00:13:52.509956+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 31,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      }
    ],
    "frameworks": [
      {
        "matchId": "87fcd352-2643-4d47-a430-ecaab122db76",
        "evidence": "The slide compares a new drug candidate against established competitors across specific criteria.",
        "framework": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-05-02 12:22:59.874+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 5,
        "frameworkName": "comparison-frame"
      },
      {
        "matchId": "017ec0ee-eb57-4baf-9289-3d375de5d707",
        "evidence": "Standard oncology efficacy visualization",
        "framework": null,
        "confidence": 1,
        "extraction": {
          "at": "2026-05-02 12:23:02.579+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 17,
        "frameworkName": "waterfall-chart"
      },
      {
        "matchId": "96d81cda-3449-4aaf-92dd-1c9f77ccbc5e",
        "evidence": "The slide presents a baseline vs. treatment progression (4w, 8w) to demonstrate efficacy.",
        "framework": null,
        "confidence": 1,
        "extraction": {
          "at": "2026-05-02 12:23:02.681+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 20,
        "frameworkName": "before-after-framing"
      },
      {
        "matchId": "f1058497-36c9-435b-b812-9a1a073dcbbb",
        "evidence": "The slide explicitly compares baseline, 4-week, and 16-week clinical imaging to demonstrate treatment efficacy.",
        "framework": null,
        "confidence": 1,
        "extraction": {
          "at": "2026-05-02 12:23:03.393+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 21,
        "frameworkName": "before-after-framing"
      },
      {
        "matchId": "8eae415d-c634-466a-a7b8-fa9879a19911",
        "evidence": "The slide uses horizontal bars to represent the progression of drug candidates through clinical trial phases over time.",
        "framework": null,
        "confidence": 1,
        "extraction": {
          "at": "2026-05-02 12:23:02.873+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 24,
        "frameworkName": "gantt-chart"
      }
    ],
    "patterns": []
  },
  "storymakers": null,
  "score": null,
  "review": null,
  "activistThesis": null,
  "pitchdeck": {
    "metadata": null,
    "profile": null
  },
  "slides": [
    {
      "page": 1,
      "type": "setup",
      "function": "front_matter",
      "imagePath": "https://imgproxy.kitesheet.com/h_FCKAK8VQr8d4-YZJInOzeipTeLEOStFmS2x9v-sTc/rs:fit:1200:1200:0/q:82/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9jZTg5NDA3MmFjMGJkYmRiNGJlMGM2ZTUyMDU5OWU1Ni9wMDAxLmpwZw",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 38,
        "componentCount": 5,
        "textChars": 169,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:22:59.179+00",
          "seconds": 2.68,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/1",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-1",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.05,
            "w": 0.3,
            "x": 0.3,
            "y": 0.85
          },
          "kind": "callout",
          "text": "PRECISELY Targeted Therapies for patients with cancer",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.179+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "fe170bc7-159c-49d0-a8d6-69656f800434",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.8,
            "w": 0.35,
            "x": 0.6,
            "y": 0.1
          },
          "kind": "image",
          "text": "Molecular structure visualization",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Illustration",
              "slug": "illustration",
              "status": "active",
              "canonId": "019de52c-fe76-7772-a5ac-c0b7294d7615",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "illustration",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.179+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "06f1354e-6fc8-4bf3-9e0e-2846a8e0058c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.3,
            "x": 0.05,
            "y": 0.15
          },
          "kind": "image",
          "text": "Nuvalent",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Logo",
              "slug": "logo",
              "status": "active",
              "canonId": "019de52c-fdaf-743d-94c4-d7c6a0e55302",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "logo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.179+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "435a266a-1179-4c99-ac0c-7abad57917ff",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.2,
            "x": 0.05,
            "y": 0.6
          },
          "kind": "paragraph",
          "text": "October 28, 2022",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.179+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6fa4e187-47d1-4a2b-b0d2-11a29315ea3a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.5,
            "x": 0.05,
            "y": 0.44
          },
          "kind": "title",
          "text": "Post-EORTC-NCI-AACR (ENA) 2022 Conference Call Presentation",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.179+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "93bff085-2e22-4110-b364-638fb32f42bd",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Slide recipe: Cover",
            "slug": "cover-slide",
            "status": "active",
            "bestFor": null,
            "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
            "version": 1,
            "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
            "description": "The first ten seconds. Build it deliberately.",
            "familyLabel": "slide-recipe",
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "designer",
          "layer": "slide",
          "agents": [
            "designer"
          ],
          "matchId": "aee04abc-84c5-4aff-9386-a7dfef288d9e",
          "evidence": "This is a cover slide with a title, headline, and logo.",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:13:28.940045+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 1,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "thumbSrc": "https://imgproxy.kitesheet.com/R6xdzlgwR7LJvgvj0PH4ASwhzeUcxvMYnSlhb7twe9Y/rs:fit:480:480:0/q:78/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9jZTg5NDA3MmFjMGJkYmRiNGJlMGM2ZTUyMDU5OWU1Ni9wMDAxLmpwZw",
      "imagePathAlt": "https://imgproxy.kitesheet.com/c5kx5TQ8FszvN2_vEvZUKOPKubUmpyvIhqnQJpEcG28/rs:fit:1200:1200:0/q:82/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9jZTg5NDA3MmFjMGJkYmRiNGJlMGM2ZTUyMDU5OWU1Ni9wMDAxLnBuZw",
      "thumbSrcAlt": "https://imgproxy.kitesheet.com/BRJi5Cm5KaInOZgPiI8Vqi7bsEl_Qicql9d9uC_5Olk/rs:fit:480:480:0/q:78/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9jZTg5NDA3MmFjMGJkYmRiNGJlMGM2ZTUyMDU5OWU1Ni9wMDAxLnBuZw"
    },
    {
      "page": 2,
      "type": "setup",
      "function": "front_matter",
      "rawType": "disclaimer",
      "block": null,
      "metadata": {
        "slideType": "disclaimer",
        "slideTypeCanon": {
          "name": "Disclaimer",
          "slug": "disclaimer",
          "status": "active",
          "canonId": "019de52d-0801-727b-b98a-5ed095aeee78",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 19,
        "componentCount": 2,
        "textChars": 270,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:22:58.498+00",
          "seconds": 1.899,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/2",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-2",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.644,
            "w": 0.846,
            "x": 0.077,
            "y": 0.231
          },
          "kind": "disclaimer",
          "text": "This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995... Nuvalent explicitly disclaims any obligation to update any forward-looking statements.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:58.498+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1ec807dc-f851-4fef-ab41-a5f9ecf57252",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.028,
            "w": 0.635,
            "x": 0.077,
            "y": 0.135
          },
          "kind": "title",
          "text": "CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:58.498+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a7a0e925-3bda-4d25-a09b-a43f9623f02b",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 3,
      "type": "setup",
      "title": "The slide uses a clean, minimalist layout with a network-style background graphic.",
      "function": "establish_context",
      "rawType": "thesis_headline",
      "block": null,
      "metadata": {
        "slideType": "thesis_headline",
        "slideTypeCanon": {
          "name": "Thesis headline",
          "slug": "thesis_headline",
          "status": "active",
          "canonId": "019de52d-073a-70cb-b9f6-772a597bb5af",
          "version": 1,
          "description": null
        },
        "function": "establish_context",
        "functionCanon": {
          "name": "Establish context",
          "slug": "establish_context",
          "status": "active",
          "canonId": "019de52d-1314-74e6-9074-d213dc0bdcdf",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 43,
        "componentCount": 4,
        "textChars": 433,
        "nDataPoints": 0,
        "notes": "The slide uses a clean, minimalist layout with a network-style background graphic.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:22:59.566+00",
          "seconds": 2.93,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/3",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-3",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.2,
            "w": 0.2,
            "x": 0.38,
            "y": 0.52
          },
          "kind": "paragraph",
          "text": "Built for Patients: Our mission is to bring new medicines to patients with cancer",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.566+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "12591fa7-5cfc-4c77-9be8-cf523603316d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.25,
            "x": 0.08,
            "y": 0.52
          },
          "kind": "paragraph",
          "text": "Chemistry at the core: Expertise in chemistry and structure-based drug design drives wholly-owned pipeline of novel targeted therapies",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.566+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7c2f498b-7ad7-4a17-934b-62b3ddede06c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.28,
            "x": 0.65,
            "y": 0.52
          },
          "kind": "paragraph",
          "text": "Driven by Purpose: Precisely designed solutions aiming to overcome limitations of existing therapies identified through close collaboration with physician-scientists",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.566+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c27eaf8d-21a6-4455-b796-7f57cdc3241e",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.45,
            "x": 0.08,
            "y": 0.18
          },
          "kind": "title",
          "text": "PRECISELY Targeted Therapies for patients with cancer",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.566+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "96b0af89-4130-446a-b8a1-dc24c6d9d0de",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 4,
      "type": "setup",
      "title": "Includes a molecular visualization of the inhibitor binding to the protein.",
      "function": "front_matter",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 24,
        "componentCount": 4,
        "textChars": 107,
        "nDataPoints": 0,
        "notes": "Includes a molecular visualization of the inhibitor binding to the protein.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:22:59.452+00",
          "seconds": 2.697,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/4",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-4",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.95,
            "w": 0.44,
            "x": 0.56,
            "y": 0.05
          },
          "kind": "image",
          "text": "Molecular structure visualization",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Illustration",
              "slug": "illustration",
              "status": "active",
              "canonId": "019de52c-fe76-7772-a5ac-c0b7294d7615",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "illustration",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.452+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c7fc0aed-f82c-4c38-860e-135fe2d0b3e8",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.015,
            "w": 0.158,
            "x": 0.842,
            "y": 0.95
          },
          "kind": "source-note",
          "text": "ROS1 image source: 4UXL.pdb",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.452+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "558ca60b-ed00-4e9b-a11f-90ac74283ad1",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.052,
            "w": 0.243,
            "x": 0.076,
            "y": 0.46
          },
          "kind": "title",
          "text": "NVL-520",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.452+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "0d38d711-1bf5-42a7-acea-d3139240dfa5",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.076,
            "w": 0.312,
            "x": 0.076,
            "y": 0.575
          },
          "kind": "title",
          "text": "Next generation ROS1-selective inhibitor",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "019de52c-fb09-739d-900c-815b0d9ac526",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "subtitle",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.452+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "2f098713-a7f7-4c48-81b0-85ef77496246",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Slide recipe: Cover",
            "slug": "cover-slide",
            "status": "active",
            "bestFor": null,
            "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
            "version": 1,
            "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
            "description": "The first ten seconds. Build it deliberately.",
            "familyLabel": "slide-recipe",
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "designer",
          "layer": "slide",
          "agents": [
            "designer"
          ],
          "matchId": "5c4c319c-1b15-46c5-b6a4-2ce4ef8a01ab",
          "evidence": "This is a cover slide with a title, subtitle, and image.",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:13:29.102955+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 4,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 5,
      "type": "setup",
      "title": "The slide uses a matrix-like structure to compare drug capabilities against specific clinical requirements.",
      "function": "compare_peers",
      "rawType": "comparison_table",
      "block": null,
      "metadata": {
        "slideType": "comparison_table",
        "slideTypeCanon": {
          "name": "Comparison table",
          "slug": "comparison_table",
          "status": "active",
          "canonId": "019de52d-0a06-73f8-8813-fe022fab1de2",
          "version": 1,
          "description": null
        },
        "function": "compare_peers",
        "functionCanon": {
          "name": "Compare peers",
          "slug": "compare_peers",
          "status": "active",
          "canonId": "019de52d-1453-72ba-a367-9ba3d34c1630",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 43,
        "componentCount": 3,
        "textChars": 833,
        "nDataPoints": 0,
        "notes": "The slide uses a matrix-like structure to compare drug capabilities against specific clinical requirements.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:22:59.874+00",
          "seconds": 2.93,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/5",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-5",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.1,
            "w": 0.86,
            "x": 0.07,
            "y": 0.86
          },
          "kind": "source-note",
          "text": "ROS1+, ROS1-positive; CNS, central nervous system; NCCN, National Comprehensive Cancer Network®; NSCLC, non-small cell lung cancer. Sources: Drilon et al., Nat. Rev. Clin. Oncol. 2021; Jordan et al., Cancer Discovery. 2017; Patil et al., J. Thorac. Oncol. 2018; Gainor et al., JCO Precision Oncol. 2017; Lin et al., CCR 2021; Cocco et al., Nat. Rev. Clin. Oncol. 2018; Drilon et al., Lancet Oncol. 2020; Doebele et al., Ann. Oncol. 2019; Shaw et al., NEJM 2020; Li et al., JCO 2022; Drilon et al., Ann. Oncol. 2019; Papadopoulos et al., Clin Cancer Res. 2020; crizotinib prescribing information; entrectinib prescribing information.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.874+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3088e447-4bf4-427e-830e-ea1294fc74e8",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.65,
            "w": 0.86,
            "x": 0.07,
            "y": 0.2
          },
          "kind": "table",
          "text": "Comparison matrix of ROS1 inhibitors (Crizotinib, Entrectinib, Lorlatinib, Taletrectinib, Repotrectinib) vs NVL-520 goal across 4 medical needs.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.874+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "abd7c3c2-b512-4df6-ab72-dd927a8aa602",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.6,
            "x": 0.07,
            "y": 0.1
          },
          "kind": "title",
          "text": "NVL-520 | A Rationally Designed Kinase Inhibitor for ROS1",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.874+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "482533c5-e892-4b11-8d8d-620d5acd01b0",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [
        {
          "matchId": "87fcd352-2643-4d47-a430-ecaab122db76",
          "evidence": "The slide compares a new drug candidate against established competitors across specific criteria.",
          "framework": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-05-02 12:22:59.874+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 5,
          "frameworkName": "comparison-frame"
        }
      ],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 6,
      "type": "tension",
      "title": "The slide uses a human anatomy diagram to map specific TRK receptor inhibition (TRKB, TRKC, TRKA) to associated clinical side effects.",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "overcrowded",
        "densityScore": 80,
        "componentCount": 8,
        "textChars": 787,
        "nDataPoints": 0,
        "notes": "The slide uses a human anatomy diagram to map specific TRK receptor inhibition (TRKB, TRKC, TRKA) to associated clinical side effects.",
        "elementsJson": null,
        "confidence": 0.95,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:00.52+00",
          "seconds": 3.29,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/6",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-6",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.03,
            "w": 0.3,
            "x": 0.43,
            "y": 0.18
          },
          "kind": "callout",
          "text": "TRK INHIBITION SAFETY IMPLICATIONS",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "0f083e11-db27-4ec7-acb3-e52b244675c3",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.85,
            "w": 0.3,
            "x": 0.065,
            "y": 0.08
          },
          "kind": "image",
          "text": "Human anatomy diagram showing CNS and peripheral nervous system",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Illustration",
              "slug": "illustration",
              "status": "active",
              "canonId": "019de52c-fe76-7772-a5ac-c0b7294d7615",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "illustration",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7f08759f-f89f-40bd-85de-f06b8259b93c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.18,
            "w": 0.3,
            "x": 0.43,
            "y": 0.67
          },
          "kind": "list",
          "text": "TRKA: Congenital insensitivity to pain with anhidrosis (CIPA); Severe sensory and sympathetic neuropathies",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "593337fb-4f84-4e81-808f-46f4cc0b0e46",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.18,
            "w": 0.3,
            "x": 0.43,
            "y": 0.22
          },
          "kind": "list",
          "text": "TRKB: Impairments in memory, learning and nociception; Development of obesity caused by hyperphagia and hyperdipsia",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b169b80b-5fee-4a02-a466-3eb02357bf61",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.18,
            "w": 0.3,
            "x": 0.43,
            "y": 0.45
          },
          "kind": "list",
          "text": "TRKC: Impairment of motor neuron afferents and loss of dorsal root ganglia neurons; Defect in proprioception",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e27905fc-7688-4df2-9e77-b915d0071d43",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.32,
            "x": 0.07,
            "y": 0.36
          },
          "kind": "paragraph",
          "text": "ROS1 and ALK both share strong structural similarities to TRK. Brain penetration is needed to address associated CNS disease in ROS1 and ALK driven cancers. Inhibitors must be highly selective to avoid CNS toxicities from off-target inhibition of TRK",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6908d4bf-e14f-4b39-bac0-2c9e09395f50",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.02,
            "w": 0.25,
            "x": 0.07,
            "y": 0.089
          },
          "kind": "source-note",
          "text": "Sources: Adapted from Cocco, Scaltriti and Drilon Nat Rev Clin Oncol 2018",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e7251d8f-690a-4a56-a740-4fe999f05f96",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.35,
            "x": 0.07,
            "y": 0.21
          },
          "kind": "title",
          "text": "Overcoming Kinase Selectivity in NSCLC",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.52+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "604b10fa-d1bb-42c9-a8c5-3af4c8ea7f1c",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 6,
          "arc": {
            "name": "The Sequoia Pitch",
            "slug": "sequoia-pitch",
            "status": "active",
            "bestFor": "Investor pitches, Series A/B, board presentations",
            "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
            "description": null,
            "familyLabel": null
          },
          "from": 6,
          "name": "Problem",
          "beatId": "645eb1af-3b23-4bf3-bf6c-a731c328939a",
          "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
          "beatType": {
            "name": "Problem",
            "slug": "sequoia-pitch-problem",
            "status": "active",
            "canonId": "019dd9b8-1ed4-767b-8e05-40e733bd2311",
            "version": 1,
            "description": null
          },
          "evidence": "Slide 6: Overcoming Kinase Selectivity in NSCLC",
          "position": 0,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Complication",
            "slug": "complication",
            "status": "active",
            "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
            "version": 1,
            "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 7,
      "type": "setup",
      "title": "The slide uses a list of icons to represent key clinical attributes of the drug candidate.",
      "function": "present_solution",
      "rawType": "key_messages",
      "block": null,
      "metadata": {
        "slideType": "key_messages",
        "slideTypeCanon": {
          "name": "Key messages",
          "slug": "key_messages",
          "status": "active",
          "canonId": "019de52d-0712-703f-89f5-bda6688faf3f",
          "version": 1,
          "description": null
        },
        "function": "present_solution",
        "functionCanon": {
          "name": "Present solution",
          "slug": "present_solution",
          "status": "active",
          "canonId": "019de52d-15b8-71da-bd23-2b767850cbce",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 34,
        "componentCount": 4,
        "textChars": 276,
        "nDataPoints": 0,
        "notes": "The slide uses a list of icons to represent key clinical attributes of the drug candidate.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:22:59.723+00",
          "seconds": 2.29,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/7",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-7",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.3,
            "w": 0.05,
            "x": 0.512,
            "y": 0.23
          },
          "kind": "image",
          "text": null,
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Icon grid",
              "slug": "icon-grid",
              "status": "active",
              "canonId": "019de52c-fdfe-749d-9990-1db465a3eed4",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "icon-grid",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.723+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4e591086-9a02-4816-b0d1-1502ebceae41",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.3,
            "w": 0.35,
            "x": 0.585,
            "y": 0.23
          },
          "kind": "list",
          "text": "Active against wild-type ROS1 fusions\nActive against treatment-emergent ROS1 resistance mutations: G2032R, D2033N, L2026M, S1986Y/F\nBrain penetrant\nTRK sparing to minimize CNS adverse events",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.723+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d78fddf6-fd15-4c32-bed5-0a6029d42a43",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.7,
            "w": 0.33,
            "x": 0.105,
            "y": 0.318
          },
          "kind": "title",
          "text": "NVL-520 for ROS1-Positive Advanced NSCLC and other Solid Tumors",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.723+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e3a2e425-ac0b-4473-8553-239b4980bae5",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.02,
            "w": 0.25,
            "x": 0.512,
            "y": 0.188
          },
          "kind": "title",
          "text": "TARGET PRODUCT PROFILE:",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "019de52c-fb09-739d-900c-815b0d9ac526",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "subtitle",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:22:59.723+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e0f1c241-c8ff-42b4-a3ff-10b3ddc68396",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 7,
          "arc": {
            "name": "The Sequoia Pitch",
            "slug": "sequoia-pitch",
            "status": "active",
            "bestFor": "Investor pitches, Series A/B, board presentations",
            "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
            "description": null,
            "familyLabel": null
          },
          "from": 7,
          "name": "Solution",
          "beatId": "6c9c65e6-1206-45c3-bfc7-f5e5a5a7b47d",
          "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
          "beatType": {
            "name": "Solution",
            "slug": "sequoia-pitch-solution",
            "status": "active",
            "canonId": "019dd9b8-1fb1-71d9-a260-07738d7f9c2f",
            "version": 1,
            "description": null
          },
          "evidence": "Slide 7: NVL-520 for ROS1-Positive Advanced NSCLC and other Solid Tumors",
          "position": 1,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Turn",
            "slug": "turn",
            "status": "active",
            "canonId": "019dd9b8-0396-702b-ac2f-9901f8dd8b54",
            "version": 1,
            "description": "The pivot — solution proposed, catalyst introduced, decision made. Common (15/20 arcs) but not universal: Triple-take, AIDA, PAS, Voyage-return and Pixar substitute it with a strong reflection or development beat."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 8,
      "type": "resolution",
      "title": "The slide uses dot plots for IC50 values and a bar chart for tumor regression, highlighting NVL-520's performance.",
      "function": "analyze_data",
      "rawType": "key_takeaways",
      "block": null,
      "metadata": {
        "slideType": "key_takeaways",
        "slideTypeCanon": {
          "name": "Key takeaways",
          "slug": "key_takeaways",
          "status": "active",
          "canonId": "019de52d-06e7-7674-a891-9f7de3b11b6d",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 62,
        "componentCount": 5,
        "textChars": 431,
        "nDataPoints": 45,
        "notes": "The slide uses dot plots for IC50 values and a bar chart for tumor regression, highlighting NVL-520's performance.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:00.295+00",
          "seconds": 2.751,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/8",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-8",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.4,
            "w": 0.3,
            "x": 0.65,
            "y": 0.35
          },
          "kind": "chart",
          "text": "In vivo efficacy tumor regression bar chart",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Grouped bar chart",
              "slug": "bar-grouped",
              "status": "active",
              "canonId": "019de52c-ff3b-751e-a8ff-f21ff11097b1",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-grouped",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.295+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "2c6da9bb-2bb8-4812-bfb2-c39a68c4d081",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.4,
            "w": 0.28,
            "x": 0.36,
            "y": 0.35
          },
          "kind": "chart",
          "text": "Resistance Mutations IC50 dot plot",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Dot plot",
              "slug": "dot",
              "status": "active",
              "canonId": "019de52d-0235-738b-bd2b-78f8e24d7cb0",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "dot",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.295+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "599e9d4c-c166-4dd9-9ad2-5f4294199d50",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.4,
            "w": 0.28,
            "x": 0.08,
            "y": 0.35
          },
          "kind": "chart",
          "text": "Fusion Partners IC50 dot plot",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Dot plot",
              "slug": "dot",
              "status": "active",
              "canonId": "019de52d-0235-738b-bd2b-78f8e24d7cb0",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "dot",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.295+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "8ff159a9-7595-4692-bfb1-f55e6e92b2e2",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.5,
            "x": 0.07,
            "y": 0.9
          },
          "kind": "source-note",
          "text": "BID, twice daily; IC50, half-maximal inhibitory concentration; PDC, patient-derived cell line. Sources: Tangpeerachaikul, A. et al., AACR 2022; Deshpande, A. et al., EORTC-NCI-AACR 2021; Pelish, H.E. et al., AACR 2021.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.295+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6612cab6-4191-4782-8a5d-40e5b7112d30",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.85,
            "x": 0.07,
            "y": 0.05
          },
          "kind": "title",
          "text": "Preclinical | NVL-520 Exhibits Potent Activity Across Diverse ROS1 Fusion Partners and Resistance Mutations",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.295+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "797f7e94-f2a1-4a21-95b1-2e84f1ff6182",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 9,
      "type": "setup",
      "title": "The chart on the right uses a logarithmic scale for the Selectivity Index.",
      "function": "analyze_data",
      "rawType": "key_messages",
      "block": null,
      "metadata": {
        "slideType": "key_messages",
        "slideTypeCanon": {
          "name": "Key messages",
          "slug": "key_messages",
          "status": "active",
          "canonId": "019de52d-0712-703f-89f5-bda6688faf3f",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 55,
        "componentCount": 4,
        "textChars": 584,
        "nDataPoints": 10,
        "notes": "The chart on the right uses a logarithmic scale for the Selectivity Index.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:00.788+00",
          "seconds": 3.049,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/9",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-9",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.5,
            "x": 0.4,
            "y": 0.34
          },
          "kind": "chart",
          "text": "Selectivity Index for NVL-520, Crizotinib, Entrectinib, Repotrectinib",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Grouped bar chart",
              "slug": "bar-grouped",
              "status": "active",
              "canonId": "019de52c-ff3b-751e-a8ff-f21ff11097b1",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-grouped",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.788+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ccf367e7-ff64-4810-b421-5a557db9f977",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.25,
            "x": 0.11,
            "y": 0.38
          },
          "kind": "chart",
          "text": "Unbound brain:plasma ratio for NVL-520 vs Lorlatinib",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Vertical bar chart",
              "slug": "bar-vertical",
              "status": "active",
              "canonId": "019de52c-fe9d-70f2-b3b7-a9ae294f5917",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-vertical",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.788+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4d261064-ec85-4397-a017-e53fdd8e7588",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.7,
            "x": 0.07,
            "y": 0.88
          },
          "kind": "subtitle",
          "text": "IC50, half-maximal inhibitory concentration; PO, orally; pTRK, BDNF-stimulated TRKB phosphorylation. Head-to-head clinical studies comparing NVL-520 with currently approved or investigational therapies have not been conducted. Above data from preclinical studies. Sources: Tangpeerachaikul, A. et al., EORTC-NCI-AACR 2021; Data on file.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "82d821ee-2793-42e7-8f16-c6131385a3ce",
              "version": 1,
              "description": "Header-zone supporting text near the title (= ex body.description with bbox)."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.788+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "375a4899-f51b-42fc-bb63-24cde10bd940",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.85,
            "x": 0.07,
            "y": 0.06
          },
          "kind": "title",
          "text": "Preclinical | NVL-520 is a Brain Penetrant, ROS1-Selective Inhibitor with the Potential to Avoid TRK-Related CNS Adverse Events",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:00.788+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f2b50f19-632d-4ff9-bdf4-7103183eda55",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 10,
      "type": "setup",
      "title": "Includes list of authors and their institutional affiliations.",
      "function": "front_matter",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 57,
        "componentCount": 5,
        "textChars": 545,
        "nDataPoints": 0,
        "notes": "Includes list of authors and their institutional affiliations.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:04.169+00",
          "seconds": 6.104,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/10",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-10",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.15,
            "w": 0.2,
            "x": 0.02,
            "y": 0.02
          },
          "kind": "image",
          "text": "ENA 2022 EORTC NCI AACR 34th Symposium",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Logo",
              "slug": "logo",
              "status": "active",
              "canonId": "019de52c-fdaf-743d-94c4-d7c6a0e55302",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "logo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.169+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "2189de23-0c9b-4361-bd57-3bf0e3bd625a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.3,
            "x": 0.02,
            "y": 0.9
          },
          "kind": "image",
          "text": "EORTC NIH NCI AACR",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Logo grid",
              "slug": "logo-grid",
              "status": "active",
              "canonId": "019de52c-fdd7-7409-93e5-81280a8ca215",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "logo-grid",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.169+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c543eadd-a838-4ee7-91be-0bd341f73729",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.84,
            "x": 0.08,
            "y": 0.5
          },
          "kind": "paragraph",
          "text": "A. Drilon1, B. Besse2, D.R. Camidge3, S.H.I. Ou4, S.M. Gadgeel5, M.L. Johnson6, A. Calles7, M.J. de Miguel8, A.I. Spira9, E. Felip10, G. Lopes11, A.J. van der Wekken12, Y.Y. Elamin13, J. Green14, Y. Sun14, J. Soglia14, V.W. Zhu14, J.J. Lin15",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.169+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "fd891577-b236-4ccd-9432-3e54c68243cc",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.84,
            "x": 0.08,
            "y": 0.65
          },
          "kind": "subtitle",
          "text": "1 Memorial Sloan Kettering Cancer Center... 15 Massachusetts General Hospital, Medicine, Boston, USA.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "82d821ee-2793-42e7-8f16-c6131385a3ce",
              "version": 1,
              "description": "Header-zone supporting text near the title (= ex body.description with bbox)."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.169+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4c2f637a-3498-4cbf-8ad2-64be957804d7",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.84,
            "x": 0.08,
            "y": 0.265
          },
          "kind": "title",
          "text": "Safety and preliminary clinical activity of NVL-520, a highly selective ROS1 inhibitor, in patients with advanced ROS1 fusion-positive solid tumors",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.169+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "23fa8372-d192-4e21-bee0-2a1595278a40",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Slide recipe: Cover",
            "slug": "cover-slide",
            "status": "active",
            "bestFor": null,
            "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
            "version": 1,
            "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
            "description": "The first ten seconds. Build it deliberately.",
            "familyLabel": "slide-recipe",
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "designer",
          "layer": "slide",
          "agents": [
            "designer"
          ],
          "matchId": "b99f940b-b2c0-42a2-8ce0-de55cb0d0f7f",
          "evidence": "This is a cover slide with a title, headline, and logo.",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:13:29.38585+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 10,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 11,
      "type": "setup",
      "title": "The slide outlines the clinical trial structure, including patient eligibility criteria and study objectives for both phases.",
      "function": "present_framework",
      "rawType": "appendix_methodology",
      "block": null,
      "metadata": {
        "slideType": "appendix_methodology",
        "slideTypeCanon": {
          "name": "Appendix methodology",
          "slug": "appendix_methodology",
          "status": "active",
          "canonId": "019de52d-07d9-726c-8599-167f2d2ffaa7",
          "version": 1,
          "description": null
        },
        "function": "present_framework",
        "functionCanon": {
          "name": "Present framework",
          "slug": "present_framework",
          "status": "active",
          "canonId": "019de52d-1403-7667-9100-d2ac6709f750",
          "version": 1,
          "description": null
        },
        "density": "overcrowded",
        "densityScore": 80,
        "componentCount": 7,
        "textChars": 1454,
        "nDataPoints": 0,
        "notes": "The slide outlines the clinical trial structure, including patient eligibility criteria and study objectives for both phases.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:08.389+00",
          "seconds": 10.07,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/11",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-11",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.1,
            "w": 0.88,
            "x": 0.06,
            "y": 0.88
          },
          "kind": "disclaimer",
          "text": "CBR, clinical benefit rate; Chemo/I-O, platinum-based chemotherapy ± immunotherapy; DOR, duration of response; MTD, maximum tolerated dose; NSCLC, non-small cell lung cancer; ORR, overall response rate (RECIST 1.1); OS, overall survival; PFS, progression-free survival; PK, pharmacokinetics; RP2D, recommended phase 2 dose; ROS1+, ROS1-positive; TKI, tyrosine kinase inhibitor; TTR, time to response. a Patients with baseline concurrent oncogenic drivers identified on subsequent testing and patients without measurable disease are excluded from efficacy evaluation per prespecified protocol analysis plan.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a07cb514-38a5-4d09-9568-c57de825d47f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.25,
            "w": 0.44,
            "x": 0.06,
            "y": 0.35
          },
          "kind": "list",
          "text": "PATIENT POPULATION: Advanced solid tumors harboring ROS1 fusions; ≥ 1 prior ROS1 TKI for NSCLC; No limit to prior chemo/I-O; Excluded: concurrent oncogenic drivers; Evaluable but non-measurable disease allowed.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "11976723-cfed-4f81-adeb-891e6bf54615",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.44,
            "x": 0.51,
            "y": 0.63
          },
          "kind": "list",
          "text": "OBJECTIVES: Primary: ORR by blinded, independent central review. Secondary: Additional efficacy measures (DOR, TTR, CBR, PFS, OS), intracranial activity, overall safety and tolerability, confirmation of PK profile.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "5addcdb8-b3c0-46d0-b894-9989d1a5b56d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.44,
            "x": 0.06,
            "y": 0.63
          },
          "kind": "list",
          "text": "OBJECTIVES: Selection of RP2D and MTD; Overall safety and tolerability; PK characterization; Preliminary antitumor activity; Intracranial activity.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "616bd911-c3f2-455e-8d07-8fe80fb4a792",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.44,
            "x": 0.06,
            "y": 0.28
          },
          "kind": "paragraph",
          "text": "PHASE 1 DOSE-ESCALATION",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ae38b71c-aeab-48e9-a0da-bc9de4a50f0b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.44,
            "x": 0.51,
            "y": 0.28
          },
          "kind": "table",
          "text": "OPEN-LABEL PHASE 2 COHORTS (PLANNED): Cohorts 2a-2e with Tumor Type, Prior ROS1 TKI, and Prior Chemo/I-O status.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "82b9265a-29b0-40bd-b093-7eec1a946329",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.88,
            "x": 0.06,
            "y": 0.12
          },
          "kind": "title",
          "text": "Study Design | ARROS-1: A Global Phase 1/2 Study of NVL-520 in Patients with Advanced ROS1-Positive NSCLC and Other Solid Tumors (NCT05118789)",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:08.389+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3d2b55fe-3fed-436d-aa0b-0127839d36e1",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 12,
      "type": "appendix",
      "title": "The slide uses a process-flow style diagram to show how initial cohorts are expanded via back-filling and then filtered into a response-evaluable population.",
      "function": "analyze_data",
      "rawType": "other",
      "block": null,
      "metadata": {
        "slideType": "other",
        "slideTypeCanon": {
          "name": "Other (fallback)",
          "slug": "other",
          "status": "active",
          "canonId": "019de52d-0af5-71ed-83de-d51ae245fc43",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 53,
        "componentCount": 4,
        "textChars": 496,
        "nDataPoints": 15,
        "notes": "The slide uses a process-flow style diagram to show how initial cohorts are expanded via back-filling and then filtered into a response-evaluable population.",
        "elementsJson": null,
        "confidence": 0.95,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:01.778+00",
          "seconds": 3.062,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/12",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-12",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.86,
            "x": 0.07,
            "y": 0.385
          },
          "kind": "diagram",
          "text": "Flow diagram showing dose levels, back-fill additions, and response-evaluable population counts.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Diagram",
              "slug": "diagram",
              "status": "active",
              "canonId": "019de52c-f9f0-734a-81de-15382ff28c65",
              "version": 1,
              "description": "Schematic or relational diagram."
            },
            "tool": null,
            "subkind": {
              "name": "Process flow",
              "slug": "process",
              "status": "active",
              "canonId": "019de52d-039c-718f-ad3a-efe9c4b3c838",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "process",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.778+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "fefdea19-fb1d-4388-84d7-50fb3aaf92b7",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.45,
            "x": 0.07,
            "y": 0.25
          },
          "kind": "paragraph",
          "text": "All-Treated Population (N = 35). Phase 1 design includes “back-fill” expansion at previously-evaluated dose levels for dose optimization. Enrollment initiated January 2022",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.778+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "86421a62-3dc9-4556-8c8b-e958ed38fb31",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.86,
            "x": 0.07,
            "y": 0.85
          },
          "kind": "source-note",
          "text": "Data as of 13 Sep 22, for patients treated by 01 Sep 2022. mg, milligram; NSCLC, non-small cell lung cancer; QD, once daily. a First response evaluation is pending for 6 patients...",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.778+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "2147ab67-b1f7-4849-91d5-80bcecec6da3",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.45,
            "x": 0.07,
            "y": 0.16
          },
          "kind": "title",
          "text": "Cohort Accrual | ARROS-1 Phase 1 Dose-Escalation",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.778+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ba46ac66-c40c-45d7-bc8e-fa20d76b01aa",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 13,
      "type": "analysis",
      "title": "The slide presents baseline patient characteristics and prior treatment history for a clinical trial cohort.",
      "function": "analyze_data",
      "rawType": "appendix_data",
      "block": null,
      "metadata": {
        "slideType": "appendix_data",
        "slideTypeCanon": {
          "name": "Appendix data",
          "slug": "appendix_data",
          "status": "active",
          "canonId": "019de52d-078a-745b-9ee4-c15f2f539acd",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 46,
        "componentCount": 3,
        "textChars": 547,
        "nDataPoints": 30,
        "notes": "The slide presents baseline patient characteristics and prior treatment history for a clinical trial cohort.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:01.771+00",
          "seconds": 2.847,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/13",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-13",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.1,
            "w": 0.45,
            "x": 0.07,
            "y": 0.82
          },
          "kind": "source-note",
          "text": "Data as of 13 Sep 22, for patients treated by 01 Sep 2022. All data shown as n (%) unless otherwise specified. CNS, central nervous system; ECOG PS, Eastern Cooperative Oncology Group performance status; NSCLC, non-small cell lung cancer; RECIST 1.1, Response Evaluation Criteria in Solid Tumours version 1.1; TKI, tyrosine kinase inhibitor. a Includes patients with untreated CNS lesions. b Categories are not mutually exclusive.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.771+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "da8ff778-154e-4a06-ad6f-da526872c96d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.85,
            "x": 0.07,
            "y": 0.25
          },
          "kind": "table",
          "text": "Patient characteristics and treatment history table",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.771+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d4eb2883-92de-412f-ada5-e92692bab8f0",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.85,
            "x": 0.07,
            "y": 0.16
          },
          "kind": "title",
          "text": "ARROS-1 Phase 1 Population | Heavily Pretreated ROS1+ Solid Tumors",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.771+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7b32c212-94e0-4f25-8f64-767cf8e3f952",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 14,
      "type": "analysis",
      "title": "Data presented at ENA 2022. N=35 patients.",
      "function": "analyze_data",
      "rawType": "kpi_overview",
      "block": null,
      "metadata": {
        "slideType": "kpi_overview",
        "slideTypeCanon": {
          "name": "KPI overview (contrarian)",
          "slug": "kpi_overview",
          "status": "active",
          "canonId": "019de52d-11d5-7328-b1d1-5368a03e7796",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 55,
        "componentCount": 4,
        "textChars": 558,
        "nDataPoints": 18,
        "notes": "Data presented at ENA 2022. N=35 patients.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.233+00",
          "seconds": 3.214,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/14",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-14",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.3,
            "w": 0.3,
            "x": 0.07,
            "y": 0.35
          },
          "kind": "list",
          "text": "No DLTs; No treatment-related SAEs; No AEs leading to dose reduction or discontinuation; No treatment-related dizziness",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.233+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "da1a9594-ded0-44b6-9efa-35b55965a331",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.85,
            "x": 0.07,
            "y": 0.9
          },
          "kind": "subtitle",
          "text": "Data as of 13 Sep 22, for patients treated by 01 Sep 2022. AE, adverse event; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; DLT, dose-limiting toxicity; SAE, serious adverse event. a Including oedema and oedema peripheral.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "82d821ee-2793-42e7-8f16-c6131385a3ce",
              "version": 1,
              "description": "Header-zone supporting text near the title (= ex body.description with bbox)."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.233+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "48fbc613-aaaa-4595-9ae3-bc29ee8ace30",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.5,
            "w": 0.55,
            "x": 0.39,
            "y": 0.3
          },
          "kind": "table",
          "text": "Treatment-Related Adverse Events (TRAEs) in >1 Patient All Treated Patients (N = 35)",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.233+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a7f22339-2eb8-465a-8ffc-92745ad58317",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.85,
            "x": 0.07,
            "y": 0.13
          },
          "kind": "title",
          "text": "Preliminary Safety Profile | Favorable and Consistent with the Highly ROS1-Selective, TRK-Sparing Design of NVL-520",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.233+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "66d675a2-871a-4bf3-87e4-bfbfdffb83fd",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 15,
      "type": "analysis",
      "title": "The chart displays a log-scale y-axis for concentration. The data supports once-daily (QD) dosing based on a 20h half-life.",
      "function": "analyze_data",
      "rawType": "kpi_overview",
      "block": null,
      "metadata": {
        "slideType": "kpi_overview",
        "slideTypeCanon": {
          "name": "KPI overview (contrarian)",
          "slug": "kpi_overview",
          "status": "active",
          "canonId": "019de52d-11d5-7328-b1d1-5368a03e7796",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 55,
        "componentCount": 4,
        "textChars": 638,
        "nDataPoints": 4,
        "notes": "The chart displays a log-scale y-axis for concentration. The data supports once-daily (QD) dosing based on a 20h half-life.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.1+00",
          "seconds": 3.018,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/15",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-15",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.55,
            "w": 0.45,
            "x": 0.07,
            "y": 0.3
          },
          "kind": "chart",
          "text": "Pharmacokinetic concentration over time for 25, 50, 75, and 100 mg QD cohorts",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Line chart",
              "slug": "line",
              "status": "active",
              "canonId": "019de52c-ff62-778f-8f6c-a952ceae8677",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "line",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.1+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "31bf424c-7815-4e11-9ddb-d5b61c08d67f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.86,
            "x": 0.07,
            "y": 0.88
          },
          "kind": "disclaimer",
          "text": "Data as of 13 Sep 22, for patients treated by 01 Sep 2022. Pharmacokinetic data for 125 mg QD cohort are not shown due to immaturity. CNS, central nervous system; h, hours; PK, pharmacokinetics; QD, once daily; SD, standard deviation.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.1+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "60e281d9-3d95-4569-93cf-bd8eb15d687c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.35,
            "x": 0.58,
            "y": 0.34
          },
          "kind": "list",
          "text": "NVL-520 exposure exceeded target levels that provide regression in preclinical models. Favorable pharmacokinetics: Low intra-cohort patient PK variability, Exposure increasing with increasing dose level, Half-life of approximately 20h supports QD dosing",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.1+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "aefef54b-99fc-4bd7-b4dc-b09fc2e2c89e",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.86,
            "x": 0.07,
            "y": 0.16
          },
          "kind": "title",
          "text": "Pharmacokinetics | NVL-520 Exposure Exceeded Predicted Efficacy Thresholds",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.1+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ba734d1a-618e-4d6b-823e-7b333c0183f0",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Chartjunk Elimination",
            "slug": "chartjunk-elimination",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b49e-7453-ab01-b60f338eeda1",
            "version": 1,
            "bodyDocId": null,
            "description": "Remove decorative elements that don't convey data: 3D effects, shadows, unnecessary gridlines",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "598f5a11-61e4-44ed-bf55-23b40b50634b",
          "evidence": "chart/line: Pharmacokinetic concentration over time for 25, 50, 75, and 100 mg QD cohorts",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 03:36:36.007415+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 15,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 16,
      "type": "analysis",
      "title": "Clinical trial data presentation for ENA 2022.",
      "function": "analyze_data",
      "rawType": "kpi_overview",
      "block": null,
      "metadata": {
        "slideType": "kpi_overview",
        "slideTypeCanon": {
          "name": "KPI overview (contrarian)",
          "slug": "kpi_overview",
          "status": "active",
          "canonId": "019de52d-11d5-7328-b1d1-5368a03e7796",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 53,
        "componentCount": 3,
        "textChars": 952,
        "nDataPoints": 35,
        "notes": "Clinical trial data presentation for ENA 2022.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:01.683+00",
          "seconds": 2.546,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/16",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-16",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.08,
            "w": 0.85,
            "x": 0.07,
            "y": 0.87
          },
          "kind": "disclaimer",
          "text": "Data as of 13 Sep 22, for response-evaluable patients with NSCLC treated by 01 Sep 2022. CNS, central nervous system, NE, not evaluable; ORR, objective response rate; PD, progressive disease, PR, partial response, RECIST 1.1, Response Evaluation Criteria in Solid Tumours version 1.1; SD, stable disease, TKI, tyrosine kinase inhibitor. a Includes 2 ongoing partial responses pending confirmation. b Includes 1 ongoing partial response pending confirmation. c Patient discontinued treatment due to clinical progression without post-baseline radiographic assessment. d These prior ROS1 TKIs were discontinued due to progressive disease in 17/18 patients.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.683+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1146d69e-f821-4353-8b86-fab7a716f2fe",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.55,
            "w": 0.85,
            "x": 0.07,
            "y": 0.288
          },
          "kind": "table",
          "text": "Table showing patient counts (n) and ORR percentages across five patient cohorts (All, ROS1 G2032R, CNS Mets, Prior TKI/Chemo, Prior Lorlatinib/Repotrectinib) and response categories (PR, SD, PD, NE).",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.683+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3b840087-baef-44f4-8c50-14bb1b1ab020",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.85,
            "x": 0.07,
            "y": 0.14
          },
          "kind": "title",
          "text": "Preliminary Efficacy | NVL-520 Induced Tumor Response Across Heavily Pretreated Patient Populations",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:01.683+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "36d9a7f5-c993-447f-90c2-d41e28a5d53c",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [
        {
          "to": 16,
          "from": 6,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "b01545f0-fd92-41f4-970e-28b5cb49def6",
          "evidence": "Slides 6-16 discuss the limitations of current treatments and the potential benefits of Nuvalent's therapies.",
          "position": 0,
          "objective": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-16 22:27:28.003066+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 17,
      "type": "analysis",
      "title": "The chart is a classic waterfall plot used in oncology clinical trials to demonstrate drug efficacy.",
      "function": "analyze_data",
      "rawType": "kpi_overview",
      "block": null,
      "metadata": {
        "slideType": "kpi_overview",
        "slideTypeCanon": {
          "name": "KPI overview (contrarian)",
          "slug": "kpi_overview",
          "status": "active",
          "canonId": "019de52d-11d5-7328-b1d1-5368a03e7796",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 58,
        "componentCount": 5,
        "textChars": 382,
        "nDataPoints": 17,
        "notes": "The chart is a classic waterfall plot used in oncology clinical trials to demonstrate drug efficacy.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.579+00",
          "seconds": 3.389,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/17",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-17",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.75,
            "x": 0.17,
            "y": 0.25
          },
          "kind": "chart",
          "text": "Waterfall plot of best % change in target lesions",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Waterfall chart",
              "slug": "waterfall",
              "status": "active",
              "canonId": "019de52d-002e-733e-b5cf-dd3beb6692cc",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "waterfall",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.579+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4cfc5283-27f9-4c32-8394-1a5325fe6ae6",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.85,
            "x": 0.07,
            "y": 0.91
          },
          "kind": "disclaimer",
          "text": "Data as of 13 Sep 22, for response-evaluable patients with NSCLC treated by 01 Sep 2022. ...",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.579+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "834ba477-d040-4c2d-b80e-8b3edec1dc24",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.08,
            "x": 0.08,
            "y": 0.35
          },
          "kind": "legend",
          "text": "KEY: 25 mg QD, 50 mg QD, 75 mg QD, 100 mg QD, 125 mg QD",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Legend",
              "slug": "legend",
              "status": "active",
              "canonId": "31361933-3d22-4c70-bbad-0801e9fffc0c",
              "version": 1,
              "description": "Color/symbol decoder placed adjacent to a chart or diagram."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.579+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e959297b-0995-40e2-8bcc-edee3f67372d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.22,
            "w": 0.85,
            "x": 0.07,
            "y": 0.68
          },
          "kind": "table",
          "text": "Patient characteristics table including dose level, prior ROS1 TKI, and prior lines of therapy",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.579+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f0a8cc22-3eb0-4c5d-8519-d23ea9a1039b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.85,
            "x": 0.07,
            "y": 0.14
          },
          "kind": "title",
          "text": "Preliminary Efficacy | Radiographic Tumor Regression Observed Across All NVL-520 Dose Levels",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.579+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c7a50579-2060-4fa8-af60-6917d15e8854",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Waterfall chart",
            "slug": "waterfall-chart",
            "status": "active",
            "bestFor": null,
            "canonId": "e2799da3-725f-44a9-a093-570f1f388e64",
            "version": 1,
            "bodyDocId": null,
            "description": null,
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "95860f3c-9539-41b8-b7ad-966ce9a045a6",
          "evidence": "chart/waterfall: Waterfall plot of best % change in target lesions",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 03:36:36.145053+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 17,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [
        {
          "matchId": "017ec0ee-eb57-4baf-9289-3d375de5d707",
          "evidence": "Standard oncology efficacy visualization",
          "framework": null,
          "confidence": 1,
          "extraction": {
            "at": "2026-05-02 12:23:02.579+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 17,
          "frameworkName": "waterfall-chart"
        }
      ],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 18,
      "type": "analysis",
      "title": "The chart is a swimmer plot (often used in oncology to show duration of response/treatment).",
      "function": "analyze_data",
      "rawType": "kpi_overview",
      "block": null,
      "metadata": {
        "slideType": "kpi_overview",
        "slideTypeCanon": {
          "name": "KPI overview (contrarian)",
          "slug": "kpi_overview",
          "status": "active",
          "canonId": "019de52d-11d5-7328-b1d1-5368a03e7796",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 67,
        "componentCount": 5,
        "textChars": 606,
        "nDataPoints": 21,
        "notes": "The chart is a swimmer plot (often used in oncology to show duration of response/treatment).",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:07.436+00",
          "seconds": 8.19,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/18",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-18",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.65,
            "w": 0.65,
            "x": 0.07,
            "y": 0.25
          },
          "kind": "chart",
          "text": "Swimmer plot of treatment duration by patient",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Horizontal bar chart",
              "slug": "bar-horizontal",
              "status": "active",
              "canonId": "019de52c-fec4-7221-986b-1cb5f5e84b1f",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-horizontal",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.436+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3523565e-cae8-4008-9464-0499f24f2145",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.8,
            "x": 0.07,
            "y": 0.94
          },
          "kind": "disclaimer",
          "text": "Data as of 13 Sep 22, for response-evaluable patients with NSCLC treated by 01 Sep 2022. PD, progressive disease; PR, partial response; QD, once daily; TKI, tyrosine kinase inhibitor.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.436+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "bdb91ca4-4522-414f-a0af-3b6ac7fb1ea0",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.25,
            "x": 0.73,
            "y": 0.4
          },
          "kind": "legend",
          "text": "Legend for treatment cohorts, response status (PR), progressive disease (PD), and ongoing status",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Legend",
              "slug": "legend",
              "status": "active",
              "canonId": "31361933-3d22-4c70-bbad-0801e9fffc0c",
              "version": 1,
              "description": "Color/symbol decoder placed adjacent to a chart or diagram."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.436+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cef4fbd2-b838-4332-83fb-f44ab58213de",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.45,
            "x": 0.45,
            "y": 0.7
          },
          "kind": "list",
          "text": "76% (16/21) response-evaluable patients continue treatment; Median (range) duration of treatment: 3.6 (1.0, 8.3+) months; No treatment discontinuation due to toxicity; Median (range) time to response: 3.6 (3.1, 4.6) weeks",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.436+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d4c7ac7b-7541-4069-809e-bcdfe6532fbd",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.6,
            "x": 0.075,
            "y": 0.16
          },
          "kind": "title",
          "text": "Time on Treatment | Sustained Duration with Follow-up Ongoing",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.436+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e1fc101b-4d7b-4037-8426-040714898718",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 19,
      "type": "appendix",
      "title": "Includes a spider plot (waterfall-like over time) and a bar chart showing allele clearance.",
      "function": "analyze_data",
      "rawType": "other",
      "block": null,
      "metadata": {
        "slideType": "other",
        "slideTypeCanon": {
          "name": "Other (fallback)",
          "slug": "other",
          "status": "active",
          "canonId": "019de52d-0af5-71ed-83de-d51ae245fc43",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 65,
        "componentCount": 5,
        "textChars": 531,
        "nDataPoints": 16,
        "notes": "Includes a spider plot (waterfall-like over time) and a bar chart showing allele clearance.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.405+00",
          "seconds": 2.905,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/19",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-19",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.5,
            "w": 0.25,
            "x": 0.68,
            "y": 0.25
          },
          "kind": "chart",
          "text": "Reduction in ROS1 G2032R Allele",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Vertical bar chart",
              "slug": "bar-vertical",
              "status": "active",
              "canonId": "019de52c-fe9d-70f2-b3b7-a9ae294f5917",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-vertical",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.405+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "46ec3f83-8bf5-494c-bb1e-052526fa2b0a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.5,
            "w": 0.3,
            "x": 0.35,
            "y": 0.25
          },
          "kind": "chart",
          "text": "Reduction in Tumor Burden in Cancers with ROS1 G2032R",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Line chart",
              "slug": "line",
              "status": "active",
              "canonId": "019de52c-ff62-778f-8f6c-a952ceae8677",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "line",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.405+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "97afd3c3-1ac6-45aa-89b3-297259469405",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.25,
            "w": 0.28,
            "x": 0.07,
            "y": 0.32
          },
          "kind": "list",
          "text": "Subgroup with known ROS1 G2032R resistance mutation: ORR: 78% (7/9); 100% (9/9) with tumor shrinkage. One patient with ROS1 D2033N with ongoing PR (-40%) pending confirmation.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.405+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "80167589-752a-450e-9641-70feeec663d6",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.88,
            "x": 0.07,
            "y": 0.9
          },
          "kind": "source-note",
          "text": "Data as of 13 Sep 22... a Includes 1 ongoing partial response pending confirmation. b Central ctDNA analysis by Guardant 360... c Bar represents week 2 result; week 8 results are pending.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.405+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "23277557-089e-4b8d-aef3-8ce395aaf7a9",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.7,
            "x": 0.07,
            "y": 0.13
          },
          "kind": "title",
          "text": "ROS1 Resistance Mutations | NVL-520 Induced Rapid Responses in TKI-Resistant Patients",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.405+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f08f1443-66f8-40a0-9f11-2df74d31295b",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Before/after framing",
            "slug": "before-after-framing",
            "status": "active",
            "bestFor": "For turnaround / reform proposals",
            "canonId": "019dd9e1-528b-72ec-a563-e5dcb9410f67",
            "version": 1,
            "bodyDocId": "019dd9a1-80bf-72e9-980b-ccd1c0cd3488",
            "description": "You visualise two futures side by side: the trajectory the target is on\ntoday, and the trajectory under your proposed intervention. The reader\nhas to see the delta to feel the stakes.\n\nIt's the rhetorical cousin of the peer-gap — same visual grammar\n(comparison), but across **time** instead of across peers.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "90d9847d-73c0-4d96-9f88-0ab606ae9820",
          "evidence": "chart/line: Reduction in Tumor Burden in Cancers with ROS1 G2032R",
          "pageRefs": null,
          "priority": null,
          "whenToUse": "For turnaround / reform proposals",
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 03:36:36.27533+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 19,
          "whyItWorks": "- It **quantifies the opportunity cost** of inaction. \"Doing nothing\"\n  becomes a concrete, visible path, not an abstraction.\n- It **makes the Answer tangible**. The prescription isn't a paragraph;\n  it's a trajectory the reader can point at.\n- It **pre-empts the status-quo defence**. Management usually argues \"we\n  have a plan\". Your chart shows what their plan looks like vs. yours.\n- It **satisfies both the Architect** (math adds up) **and the Storyteller**\n  (emotional delta between two futures).",
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 20,
      "type": "evidence",
      "title": "The slide uses a before-after-during progression (Baseline, 4 weeks, 8 weeks) to visualize drug efficacy.",
      "function": "illustrate_case",
      "rawType": "before_after",
      "block": null,
      "metadata": {
        "slideType": "before_after",
        "slideTypeCanon": {
          "name": "Before / after",
          "slug": "before_after",
          "status": "active",
          "canonId": "019de52d-11fd-771e-bb45-e27f849bc560",
          "version": 1,
          "description": null
        },
        "function": "illustrate_case",
        "functionCanon": {
          "name": "Illustrate case",
          "slug": "illustrate_case",
          "status": "active",
          "canonId": "019de52d-13b4-772c-bb73-1873612a7463",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 63,
        "componentCount": 5,
        "textChars": 577,
        "nDataPoints": 4,
        "notes": "The slide uses a before-after-during progression (Baseline, 4 weeks, 8 weeks) to visualize drug efficacy.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.681+00",
          "seconds": 2.977,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/20",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-20",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.15,
            "w": 0.35,
            "x": 0.07,
            "y": 0.83
          },
          "kind": "disclaimer",
          "text": "Data as of 13 Sep 22... Images courtesy of Jessica J Lin, Massachusetts General Hospital",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.681+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "786a3703-ecd3-40aa-8f3d-fcd2b4278b44",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.78,
            "w": 0.525,
            "x": 0.435,
            "y": 0.215
          },
          "kind": "image",
          "text": "MRI scans at Baseline, 4 weeks, and 8 weeks",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.681+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e1e204da-a8d9-4752-b71c-c63f1c9133a6",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.25,
            "w": 0.35,
            "x": 0.07,
            "y": 0.41
          },
          "kind": "list",
          "text": "Intracranial PR in 3/3 patients with measurable (>10 mm) CNS metastases; ORR of 73% (8/11) in response-evaluable patients; No CNS progression observed in any of the 35 treated patients",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.681+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "16851b3c-be0c-4b7b-bcc3-a6e2f6a38988",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.525,
            "x": 0.435,
            "y": 0.82
          },
          "kind": "paragraph",
          "text": "Intracranial response in 65-year-old female with CD74-ROS1 fusion NSCLC, previously treated with chemotherapy, crizotinib, and lorlatinib with CNS progression and no known ROS1 resistance mutations.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.681+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "8c36dbed-c814-4710-9121-c2885f08d278",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.35,
            "x": 0.07,
            "y": 0.21
          },
          "kind": "title",
          "text": "CNS Activity | NVL-520 Induced Responses in Intracranial Lesions",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.681+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a2b0c7f8-5bbd-4ad2-b652-11f806ad16d9",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Before-After-Bridge",
            "slug": "before-after-bridge",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-8604-7188-883f-42370288ad05",
            "version": 1,
            "bodyDocId": null,
            "description": "Narrative structure: Paint the before, show the after, explain the bridge",
            "familyLabel": null,
            "categoryName": "Block",
            "categorySlug": "block"
          },
          "agent": "Storyteller",
          "layer": "slide",
          "agents": [
            "Storyteller"
          ],
          "matchId": "4368b258-701c-40c8-af56-5f3378f823a7",
          "evidence": "image/photo: MRI scans at Baseline, 4 weeks, and 8 weeks",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 03:36:36.359151+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 20,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [
        {
          "matchId": "96d81cda-3449-4aaf-92dd-1c9f77ccbc5e",
          "evidence": "The slide presents a baseline vs. treatment progression (4w, 8w) to demonstrate efficacy.",
          "framework": null,
          "confidence": 1,
          "extraction": {
            "at": "2026-05-02 12:23:02.681+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 20,
          "frameworkName": "before-after-framing"
        }
      ],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 21,
      "type": "evidence",
      "title": "The slide uses a timeline-style list on the left to describe the patient's treatment history and a before-after image grid on the right to show clinical respons",
      "function": "illustrate_case",
      "rawType": "before_after",
      "block": null,
      "metadata": {
        "slideType": "before_after",
        "slideTypeCanon": {
          "name": "Before / after",
          "slug": "before_after",
          "status": "active",
          "canonId": "019de52d-11fd-771e-bb45-e27f849bc560",
          "version": 1,
          "description": null
        },
        "function": "illustrate_case",
        "functionCanon": {
          "name": "Illustrate case",
          "slug": "illustrate_case",
          "status": "active",
          "canonId": "019de52d-13b4-772c-bb73-1873612a7463",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 69,
        "componentCount": 5,
        "textChars": 979,
        "nDataPoints": 4,
        "notes": "The slide uses a timeline-style list on the left to describe the patient's treatment history and a before-after image grid on the right to show clinical response.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:03.393+00",
          "seconds": 3.664,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/21",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-21",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.05,
            "w": 0.9,
            "x": 0.07,
            "y": 0.92
          },
          "kind": "disclaimer",
          "text": "Data as of 13 Sep 22. CT, computed tomography; MRI, magnetic resonance imagine; NSCLC, non-small cell lung cancer; PD, Progressive Disease; QD, once daily; RECIST 1.1, Response Evaluation Criteria in Solid Tumours version 1.1; TKI, tyrosine kinase inhibitor. Images courtesy of Alexander Drilon, Memorial Sloan Kettering Cancer Center.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.393+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6a05384a-8ff1-47ad-b414-3f57010c3c68",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.55,
            "w": 0.5,
            "x": 0.45,
            "y": 0.24
          },
          "kind": "image",
          "text": "CT and MRI scans at Baseline, 4 weeks, and 16 weeks.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.393+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "52ad2bbf-bff6-482c-992c-85651af07205",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.5,
            "w": 0.4,
            "x": 0.07,
            "y": 0.275
          },
          "kind": "list",
          "text": "Diagnosis: EZR-ROS1 fusion NSCLC; Entrectinib (~9 months, ROS1 G2032R found on PD); Repotrectinib (~8 weeks); Platinum-based chemo + bevacizumab + entrectinib (~8 weeks, primary PD); NVL-520 (50 mg QD) with PR at 4 weeks and regression at 16 weeks.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Timeline item",
              "slug": "timeline-item",
              "status": "active",
              "canonId": "019de52c-fd0e-74ce-9443-440fbd8c23b4",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "timeline-item",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.393+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "0f5d2c73-9b45-458a-b90e-9e3397a6f740",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.5,
            "x": 0.45,
            "y": 0.82
          },
          "kind": "subtitle",
          "text": "Upper panel: CT indicating segment 5/6 and 3 liver metastases with continuous regression over the course of treatment. Lower panel: MRI demonstrating right occipital lobe metastasis that decreased in size at week 4 and became barely appreciable at week 16.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "82d821ee-2793-42e7-8f16-c6131385a3ce",
              "version": 1,
              "description": "Header-zone supporting text near the title (= ex body.description with bbox)."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.393+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3f0673a2-9638-4e64-ba0a-a810e1733bc2",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.85,
            "x": 0.07,
            "y": 0.13
          },
          "kind": "title",
          "text": "Case Study | Intracranial and Extracranial Activity in TKI-Refractory ROS1 G2032R+ NSCLC",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.393+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "213d7305-d451-41ec-bd77-3f20fec30a3e",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Before-After-Bridge",
            "slug": "before-after-bridge",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-8604-7188-883f-42370288ad05",
            "version": 1,
            "bodyDocId": null,
            "description": "Narrative structure: Paint the before, show the after, explain the bridge",
            "familyLabel": null,
            "categoryName": "Block",
            "categorySlug": "block"
          },
          "agent": "Storyteller",
          "layer": "slide",
          "agents": [
            "Storyteller"
          ],
          "matchId": "0586663b-5808-4238-bace-816990f50784",
          "evidence": "The slide shows a before-after comparison with CT and MRI scans at Baseline, 4 weeks, and 16 weeks.",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-07-17 03:36:29.139629+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 21,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [
        {
          "matchId": "f1058497-36c9-435b-b812-9a1a073dcbbb",
          "evidence": "The slide explicitly compares baseline, 4-week, and 16-week clinical imaging to demonstrate treatment efficacy.",
          "framework": null,
          "confidence": 1,
          "extraction": {
            "at": "2026-05-02 12:23:03.393+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 21,
          "frameworkName": "before-after-framing"
        }
      ],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 22,
      "type": "resolution",
      "title": "Slide 22 of a conference presentation.",
      "function": "summarize",
      "rawType": "key_takeaways",
      "block": null,
      "metadata": {
        "slideType": "key_takeaways",
        "slideTypeCanon": {
          "name": "Key takeaways",
          "slug": "key_takeaways",
          "status": "active",
          "canonId": "019de52d-06e7-7674-a891-9f7de3b11b6d",
          "version": 1,
          "description": null
        },
        "function": "summarize",
        "functionCanon": {
          "name": "Summarize",
          "slug": "summarize",
          "status": "active",
          "canonId": "019de52d-1541-704f-b86f-bf7b75056373",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 73,
        "componentCount": 6,
        "textChars": 1079,
        "nDataPoints": 0,
        "notes": "Slide 22 of a conference presentation.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:04.256+00",
          "seconds": 4.371,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/22",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-22",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.235,
            "w": 0.848,
            "x": 0.076,
            "y": 0.318
          },
          "kind": "list",
          "text": "In the ongoing ARROS-1 Phase 1 dose-escalation, a wide dose range resulted in exposures exceeding predicted efficacy thresholds without indication of off-target toxicity. NVL-520 has been well tolerated with no DLTs. No dose reductions or treatment discontinuations due to adverse events. Emerging safety profile is consistent with ROS1-selective, TRK-sparing design.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.256+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "25c31a55-f873-4408-aa23-8a545e3bdc79",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.035,
            "w": 0.848,
            "x": 0.076,
            "y": 0.865
          },
          "kind": "list",
          "text": "Phase 1 ongoing to further understand the safety profile, PK, and preliminary efficacy, and determine the RP2D",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.256+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3454d044-7dc3-4ff5-b9ab-959f4f76a3f1",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.215,
            "w": 0.848,
            "x": 0.076,
            "y": 0.588
          },
          "kind": "list",
          "text": "This preliminary dataset indicates encouraging clinical activity in a heavily pre-treated population, with responses observed in patients: with and without ROS1 G2032R resistance; who progressed through lorlatinib or repotrectinib; with brain metastases.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.256+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7fadd484-3da7-4eee-88b6-1dcc684a9f2c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.025,
            "w": 0.685,
            "x": 0.076,
            "y": 0.942
          },
          "kind": "source-note",
          "text": "CNS, central nervous system; DLTs, dose-limiting toxicities; NSCLC, non-small cell lung cancer; PK, pharmacokinetics; RP2D, recommended phase 2 dose.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.256+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6abd0aec-260b-4589-b272-7be1985de381",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.078,
            "w": 0.848,
            "x": 0.076,
            "y": 0.195
          },
          "kind": "title",
          "text": "NVL-520 is a brain-penetrant, selective inhibitor of ROS1 and ROS1 resistance mutations with the potential to minimize TRK-related CNS adverse events while providing CNS antitumor activity",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Action title",
              "slug": "action-title",
              "status": "active",
              "canonId": "019de52c-fb31-734c-a0f5-a3935b73135d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "action-title",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.256+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "22e12fdf-2b8f-4f07-911f-49b5529d492a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.028,
            "w": 0.196,
            "x": 0.076,
            "y": 0.145
          },
          "kind": "title",
          "text": "CONCLUSIONS",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:04.256+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4a59b7f3-0a03-4891-a5c3-6dfe26c4fe2b",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 23,
      "type": "setup",
      "function": "transition",
      "rawType": "section_divider",
      "block": null,
      "metadata": {
        "slideType": "section_divider",
        "slideTypeCanon": {
          "name": "Section divider",
          "slug": "section_divider",
          "status": "active",
          "canonId": "019de52d-066a-7402-9554-6ae504999041",
          "version": 1,
          "description": null
        },
        "function": "transition",
        "functionCanon": {
          "name": "Transition",
          "slug": "transition",
          "status": "active",
          "canonId": "019de52d-1365-7149-92aa-66df859e75fd",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 1,
        "componentCount": 1,
        "textChars": 17,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.021+00",
          "seconds": 2.083,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/23",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-23",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.09,
            "w": 0.42,
            "x": 0.077,
            "y": 0.45
          },
          "kind": "title",
          "text": "Nuvalent Pipeline",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.021+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f9d9a273-6a15-4eaa-840a-5313a58be5e4",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 24,
      "type": "resolution",
      "title": "The slide uses a Gantt-style timeline to represent drug development stages.",
      "function": "plan_implementation",
      "rawType": "roadmap",
      "block": null,
      "metadata": {
        "slideType": "roadmap",
        "slideTypeCanon": {
          "name": "Roadmap",
          "slug": "roadmap",
          "status": "active",
          "canonId": "019de52d-0a55-72bc-9b7b-a47ef109839c",
          "version": 1,
          "description": null
        },
        "function": "plan_implementation",
        "functionCanon": {
          "name": "Plan implementation",
          "slug": "plan_implementation",
          "status": "active",
          "canonId": "019de52d-14a2-77ea-b210-d6a95eed4823",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 34,
        "componentCount": 4,
        "textChars": 281,
        "nDataPoints": 0,
        "notes": "The slide uses a Gantt-style timeline to represent drug development stages.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.873+00",
          "seconds": 2.899,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/24",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-24",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.35,
            "x": 0.34,
            "y": 0.33
          },
          "kind": "framework",
          "text": "Pipeline timeline visualization",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Framework",
              "slug": "framework",
              "status": "active",
              "canonId": "019de52c-fa18-77c6-b10a-ccb8277ac0fa",
              "version": 1,
              "description": "Named conceptual framework instance."
            },
            "tool": null,
            "subkind": {
              "name": "Framework instance",
              "slug": "instance",
              "status": "active",
              "canonId": "019de52d-05a2-72af-be0b-7edc60708a03",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "instance",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.873+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4608c3ed-3d05-423f-94d9-5f6e41a61b4a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.9,
            "x": 0.05,
            "y": 0.265
          },
          "kind": "table",
          "text": "Pipeline table with columns for Indication, Candidate, Mutations, Phases, Milestones, and Rights.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.873+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c4141f43-88c7-446d-9c25-195e96039724",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.85,
            "x": 0.07,
            "y": 0.18
          },
          "kind": "title",
          "text": "Advancing parallel lead programs in ROS1-positive and ALK-positive NSCLC, and multiple early-stage discovery programs",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Action title",
              "slug": "action-title",
              "status": "active",
              "canonId": "019de52c-fb31-734c-a0f5-a3935b73135d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "action-title",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.873+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "030d90d6-cb02-4cf9-9f89-43cb3e354c07",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.45,
            "x": 0.07,
            "y": 0.11
          },
          "kind": "title",
          "text": "Nuvalent Pipeline – Ongoing Programs",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.873+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "deb1e1d5-c3b5-4ffe-9742-a7f58ccc64b0",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Table data",
            "slug": "table-data",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4fab-7168-a82f-b847350a006d",
            "version": 1,
            "bodyDocId": null,
            "description": "Tabular layouts of structured data.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "c73ad32f-4f3a-446b-bdc8-8f8ee8c88c0a",
          "evidence": "Pipeline table with columns for Indication, Candidate, Mutations, Phases, Milestones, and Rights",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:13:51.843241+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 24,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [
        {
          "matchId": "8eae415d-c634-466a-a7b8-fa9879a19911",
          "evidence": "The slide uses horizontal bars to represent the progression of drug candidates through clinical trial phases over time.",
          "framework": null,
          "confidence": 1,
          "extraction": {
            "at": "2026-05-02 12:23:02.873+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 24,
          "frameworkName": "gantt-chart"
        }
      ],
      "arcBeats": [
        {
          "to": 24,
          "arc": {
            "name": "The Sequoia Pitch",
            "slug": "sequoia-pitch",
            "status": "active",
            "bestFor": "Investor pitches, Series A/B, board presentations",
            "canonId": "019dd956-5e69-75a7-a0a4-895ac1bc0444",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem -> Solution -> Why Now -> Market Size -> Competition -> Product -> Business Model -> Team -> Financials -> The Ask",
            "description": null,
            "familyLabel": null
          },
          "from": 24,
          "name": "Market Size",
          "beatId": "fb539b55-6d05-405d-8cdc-98ff53e69b9f",
          "matchId": "36f78e05-2c8e-4990-a240-a05a0dced861",
          "beatType": {
            "name": "Market Size",
            "slug": "sequoia-pitch-market-size",
            "status": "active",
            "canonId": "019dd9b8-20e6-729c-bc28-05442906d032",
            "version": 1,
            "description": null
          },
          "evidence": "Slide 24: Nuvalent Pipeline – Ongoing Programs",
          "position": 2,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Evidence",
            "slug": "evidence",
            "status": "active",
            "canonId": "019dd9b8-03f9-772a-b84a-4f07b415b77a",
            "version": 1,
            "description": "A dedicated proof beat exists in only ~4 arcs (Gambit, Sequoia, AIDA, Monroes). Other arcs embed evidence inline within development."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [],
      "locked": true
    },
    {
      "page": 25,
      "type": "setup",
      "function": "present_solution",
      "rawType": "key_messages",
      "block": null,
      "metadata": {
        "slideType": "key_messages",
        "slideTypeCanon": {
          "name": "Key messages",
          "slug": "key_messages",
          "status": "active",
          "canonId": "019de52d-0712-703f-89f5-bda6688faf3f",
          "version": 1,
          "description": null
        },
        "function": "present_solution",
        "functionCanon": {
          "name": "Present solution",
          "slug": "present_solution",
          "status": "active",
          "canonId": "019de52d-15b8-71da-bd23-2b767850cbce",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 69,
        "componentCount": 7,
        "textChars": 389,
        "nDataPoints": 1,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:03.081+00",
          "seconds": 3.023,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/25",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-25",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.55,
            "w": 0.058,
            "x": 0.512,
            "y": 0.265
          },
          "kind": "image",
          "text": null,
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Icon grid",
              "slug": "icon-grid",
              "status": "active",
              "canonId": "019de52c-fdfe-749d-9990-1db465a3eed4",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "icon-grid",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3febd995-8ebc-41c8-be54-f076a2269f02",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.28,
            "x": 0.586,
            "y": 0.75
          },
          "kind": "list",
          "text": "TRK sparing to minimize CNS adverse events",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "876760d9-bbaa-4969-b13c-939f6941d935",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.35,
            "x": 0.586,
            "y": 0.575
          },
          "kind": "list",
          "text": "Brain penetrant ~30 – 40% of patients with ALK-positive NSCLC present with brain metastases",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c2f66f63-7b5f-4f05-a5be-76a3882a2d17",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.37,
            "x": 0.586,
            "y": 0.418
          },
          "kind": "list",
          "text": "Active against treatment-emergent ALK G1202R single and compound resistance mutations e.g., G1202R/L1196M, G1202R/G1269A, G1202R/L1198F",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c807f33a-6cc4-4ced-8614-c4ae5cb127d1",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.02,
            "w": 0.28,
            "x": 0.586,
            "y": 0.29
          },
          "kind": "list",
          "text": "Active against wild-type ALK fusions",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f9e7afd0-3946-4c5d-a3c6-90a4f3d67d87",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.332,
            "x": 0.106,
            "y": 0.318
          },
          "kind": "title",
          "text": "NVL-655 for ALK-Positive Advanced NSCLC and Other Solid Tumors",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1b26e2d4-ec73-4246-afd7-3abe1dbcb3a5",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.02,
            "w": 0.252,
            "x": 0.512,
            "y": 0.188
          },
          "kind": "title",
          "text": "TARGET PRODUCT PROFILE:",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.081+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "9d41b385-752e-4d2a-a304-31f925d5f255",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "List presentation",
            "slug": "list-presentation",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
            "version": 1,
            "bodyDocId": null,
            "description": "Bulleted, numbered, or checklist enumerations.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "b1c06be6-3b8c-44f8-9542-40bc8229e8bb",
          "evidence": "list/bullet: Active against treatment-emergent ALK G1202R single and compound resistance mutations e.g., G1202R/L1196M, G1202R/G1269A, G1202R/L1198F",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-07-17 00:13:51.914596+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 25,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 26,
      "type": "resolution",
      "title": "The slide uses a combination of scatter plots, bar charts, and a waterfall-style selectivity chart to demonstrate drug efficacy and safety profile.",
      "function": "analyze_data",
      "rawType": "key_takeaways",
      "block": null,
      "metadata": {
        "slideType": "key_takeaways",
        "slideTypeCanon": {
          "name": "Key takeaways",
          "slug": "key_takeaways",
          "status": "active",
          "canonId": "019de52d-06e7-7674-a891-9f7de3b11b6d",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 63,
        "componentCount": 5,
        "textChars": 470,
        "nDataPoints": 25,
        "notes": "The slide uses a combination of scatter plots, bar charts, and a waterfall-style selectivity chart to demonstrate drug efficacy and safety profile.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:06.362+00",
          "seconds": 6.254,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/26",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-26",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.6,
            "w": 0.35,
            "x": 0.6,
            "y": 0.2
          },
          "kind": "chart",
          "text": "Avoiding TRK inhibition",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Grouped bar chart",
              "slug": "bar-grouped",
              "status": "active",
              "canonId": "019de52c-ff3b-751e-a8ff-f21ff11097b1",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-grouped",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:06.362+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cfb30c0b-da30-492b-b8e3-52b12391a8cd",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.2,
            "x": 0.38,
            "y": 0.2
          },
          "kind": "chart",
          "text": "Brain penetrance",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Vertical bar chart",
              "slug": "bar-vertical",
              "status": "active",
              "canonId": "019de52c-fe9d-70f2-b3b7-a9ae294f5917",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-vertical",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:06.362+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1e686a26-315d-4ab6-9f5b-d13eabec9670",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.3,
            "x": 0.07,
            "y": 0.2
          },
          "kind": "chart",
          "text": "Activity against ALK wild-type and mutants",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Scatter plot",
              "slug": "scatter",
              "status": "active",
              "canonId": "019de52d-007d-72ec-8689-c79fb78e21a2",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "scatter",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:06.362+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "2a5c4ff2-c2a0-46e5-985d-c2abb3b5cce7",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.7,
            "x": 0.07,
            "y": 0.88
          },
          "kind": "disclaimer",
          "text": "IC50, half-maximal inhibitory concentration; PO, orally; pTRK, BDNF-stimulated TRKB phosphorylation. Head-to-head clinical studies comparing NVL-655 with currently approved or investigational therapies have not been conducted. Above data from preclinical studies.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:06.362+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "bd069d79-1e47-4a07-a2fc-1808b4405c01",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.85,
            "x": 0.07,
            "y": 0.05
          },
          "kind": "title",
          "text": "Preclinical | NVL-655 is a Brain Penetrant, ALK-Selective Inhibitor with the Potential to Avoid TRK-Related CNS Adverse Events",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:06.362+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cea8bbc8-e4e6-4a17-aaff-3ec252264bb3",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "861177a9-2a41-4b2b-a260-8041180323c3",
          "evidence": "chart/scatter: Activity against ALK wild-type and mutants",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:51.985214+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 26,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        },
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "e6b592c3-4631-4cb8-82ca-fe9dcabce9a6",
          "evidence": "chart/bar-grouped: Avoiding TRK inhibition",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.019939+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 26,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        },
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "0191297e-1812-4c15-b64d-f936259da331",
          "evidence": "chart/bar-vertical: Brain penetrance",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.055038+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 26,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 27,
      "type": "appendix",
      "title": "The slide compares vehicle control vs NVL-655 treatment across multiple cell lines and a patient-derived xenograft (PDX) model.",
      "function": "analyze_data",
      "rawType": "other",
      "block": null,
      "metadata": {
        "slideType": "other",
        "slideTypeCanon": {
          "name": "Other (fallback)",
          "slug": "other",
          "status": "active",
          "canonId": "019de52d-0af5-71ed-83de-d51ae245fc43",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 67,
        "componentCount": 5,
        "textChars": 593,
        "nDataPoints": 20,
        "notes": "The slide compares vehicle control vs NVL-655 treatment across multiple cell lines and a patient-derived xenograft (PDX) model.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:07.824+00",
          "seconds": 7.607,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/27",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-27",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.35,
            "w": 0.4,
            "x": 0.08,
            "y": 0.38
          },
          "kind": "chart",
          "text": "Change in tumor size (%) across various models for Vehicle vs NVL-655",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Grouped bar chart",
              "slug": "bar-grouped",
              "status": "active",
              "canonId": "019de52c-ff3b-751e-a8ff-f21ff11097b1",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-grouped",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.824+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "9aafe68e-b731-4831-870c-3b87f70bf9bb",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.35,
            "x": 0.53,
            "y": 0.38
          },
          "kind": "chart",
          "text": "Tumor volume (mm3) over days on treatment for PDX model",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Line chart",
              "slug": "line",
              "status": "active",
              "canonId": "019de52c-ff62-778f-8f6c-a952ceae8677",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "line",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.824+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "bd35f8dd-af77-4d45-ad1f-1e3b685f3850",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.4,
            "x": 0.53,
            "y": 0.75
          },
          "kind": "list",
          "text": "MGH953-7 model derived from a patient with ALK fusion-positive NSCLC; Progressed on sequential treatments; Harbors EML4-ALK v3 G1202R/L1196M",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.824+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "dac4832a-3fbe-4367-9b07-bc54ab335fca",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.85,
            "x": 0.07,
            "y": 0.93
          },
          "kind": "source-note",
          "text": "BID, twice daily; Sources: Pelish H.E. et al., AACR 2021; Tangpeerachaikul A. et al., EORTC-NCI-AACR 2021; Tangpeerachaikul A. et al., AACR 2022; Mizuta H. et al., WCLC 2022; Fujino T. et al., EORTC-NCI-AACR 2022.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.824+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d59d5de0-f747-4be0-8ad5-09b3a5f45bdd",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.85,
            "x": 0.07,
            "y": 0.06
          },
          "kind": "title",
          "text": "Preclinical | NVL-655 Induced Tumor Regression Across Models of Diverse ALK Single and Compound Resistance Mutations",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.824+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "973a3bee-5d76-4e69-8843-38a03c37121f",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "16f9f379-c123-41d9-8af0-2f15fa39e825",
          "evidence": "chart/bar-grouped: Change in tumor size (%) across various models for Vehicle vs NVL-655",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.126179+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 27,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        },
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "cdd37823-488b-4d77-84d1-5891f677ab58",
          "evidence": "chart/line: Tumor volume (mm3) over days on treatment for PDX model",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.161007+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 27,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 28,
      "type": "analysis",
      "title": "The slide uses a structured table to define patient eligibility criteria for different cohorts in a clinical trial.",
      "function": "analyze_data",
      "rawType": "appendix_data",
      "block": null,
      "metadata": {
        "slideType": "appendix_data",
        "slideTypeCanon": {
          "name": "Appendix data",
          "slug": "appendix_data",
          "status": "active",
          "canonId": "019de52d-078a-745b-9ee4-c15f2f539acd",
          "version": 1,
          "description": null
        },
        "function": "analyze_data",
        "functionCanon": {
          "name": "Analyze data",
          "slug": "analyze_data",
          "status": "active",
          "canonId": "019de52d-1590-7413-8c82-cc218cff40b4",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 37,
        "componentCount": 3,
        "textChars": 371,
        "nDataPoints": 12,
        "notes": "The slide uses a structured table to define patient eligibility criteria for different cohorts in a clinical trial.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:02.709+00",
          "seconds": 2.323,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/28",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-28",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.1,
            "w": 0.86,
            "x": 0.07,
            "y": 0.85
          },
          "kind": "disclaimer",
          "text": "* Patients with ALK fusion-positive NSCLC must have previously received ≥1 ALK TKI... ** Excluding investigational agents... *** Exploratory cohort...",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.709+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "386c8180-ae76-4094-8118-626315fd3a83",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.55,
            "w": 0.86,
            "x": 0.07,
            "y": 0.25
          },
          "kind": "table",
          "text": "Phase 1 and Phase 2 cohort definitions including tumor type, prior TKI, and prior chemo lines.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.709+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "03fe2f79-f490-47ab-994a-cee000bf2ecb",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.8,
            "x": 0.07,
            "y": 0.05
          },
          "kind": "title",
          "text": "ALKove-1 First-in-Human Phase 1/2 Clinical Trial of NVL-655 in Advanced ALK-Positive NSCLC and Other Solid Tumors (NCT05384626)",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:02.709+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b18972f6-d324-4a8d-87a6-758b97507a19",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Table data",
            "slug": "table-data",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4fab-7168-a82f-b847350a006d",
            "version": 1,
            "bodyDocId": null,
            "description": "Tabular layouts of structured data.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "4f78bb96-c029-4898-b367-d6cc303e04e1",
          "evidence": "table/data: Phase 1 and Phase 2 cohort definitions including tumor type, prior TKI, and prior chemo lines",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:13:52.230701+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 28,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 29,
      "type": "setup",
      "function": "present_solution",
      "rawType": "thesis_headline",
      "block": null,
      "metadata": {
        "slideType": "thesis_headline",
        "slideTypeCanon": {
          "name": "Thesis headline",
          "slug": "thesis_headline",
          "status": "active",
          "canonId": "019de52d-073a-70cb-b9f6-772a597bb5af",
          "version": 1,
          "description": null
        },
        "function": "present_solution",
        "functionCanon": {
          "name": "Present solution",
          "slug": "present_solution",
          "status": "active",
          "canonId": "019de52d-15b8-71da-bd23-2b767850cbce",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 58,
        "componentCount": 6,
        "textChars": 288,
        "nDataPoints": 1,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:03.583+00",
          "seconds": 2.98,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/29",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-29",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.42,
            "w": 0.055,
            "x": 0.512,
            "y": 0.335
          },
          "kind": "image",
          "text": null,
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Icon grid",
              "slug": "icon-grid",
              "status": "active",
              "canonId": "019de52c-fdfe-749d-9990-1db465a3eed4",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "icon-grid",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.583+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "be8c6700-b6fa-46ac-a75f-9868be6f9fd8",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.3,
            "x": 0.586,
            "y": 0.682
          },
          "kind": "list",
          "text": "Brain penetrant. ~20% of patients with HER2-positive NSCLC present with brain metastases",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.583+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "5dad59bb-57c8-4831-a7f8-7bbe7916228b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.025,
            "w": 0.3,
            "x": 0.586,
            "y": 0.362
          },
          "kind": "list",
          "text": "Active against HER2 and HER2ex20",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.583+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d075f049-9bf2-45c9-a463-70f939c16d19",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.3,
            "x": 0.586,
            "y": 0.495
          },
          "kind": "list",
          "text": "EGFR sparing. Related adverse events include skin rash and diarrhea",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.583+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d654e178-2541-42f4-b037-5ec51f42f34d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.28,
            "w": 0.35,
            "x": 0.106,
            "y": 0.358
          },
          "kind": "title",
          "text": "NVL-330 for Malignancies Driven by HER2 Exon 20 Insertion Mutations (HER2ex20)",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.583+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "9761e87a-1c6c-4e13-8613-925cbb98cd35",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.025,
            "w": 0.25,
            "x": 0.512,
            "y": 0.233
          },
          "kind": "title",
          "text": "TARGET PRODUCT PROFILE:",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "019de52c-fb09-739d-900c-815b0d9ac526",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "subtitle",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.583+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "125d4c4c-eb0a-45eb-9cca-16a9b07971a2",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "List presentation",
            "slug": "list-presentation",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
            "version": 1,
            "bodyDocId": null,
            "description": "Bulleted, numbered, or checklist enumerations.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "d38b12e1-42f6-438e-a6d8-f005c45aa77c",
          "evidence": "list/bullet: Brain penetrant. ~20% of patients with HER2-positive NSCLC present with brain metastases",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-07-17 00:13:52.300063+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 29,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 30,
      "type": "resolution",
      "title": "The slide uses three distinct chart types to demonstrate drug efficacy and safety profile.",
      "function": "summarize",
      "rawType": "key_takeaways",
      "block": null,
      "metadata": {
        "slideType": "key_takeaways",
        "slideTypeCanon": {
          "name": "Key takeaways",
          "slug": "key_takeaways",
          "status": "active",
          "canonId": "019de52d-06e7-7674-a891-9f7de3b11b6d",
          "version": 1,
          "description": null
        },
        "function": "summarize",
        "functionCanon": {
          "name": "Summarize",
          "slug": "summarize",
          "status": "active",
          "canonId": "019de52d-1541-704f-b86f-bf7b75056373",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 63,
        "componentCount": 5,
        "textChars": 490,
        "nDataPoints": 15,
        "notes": "The slide uses three distinct chart types to demonstrate drug efficacy and safety profile.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:03.361+00",
          "seconds": 2.71,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/30",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-30",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.65,
            "w": 0.21,
            "x": 0.72,
            "y": 0.22
          },
          "kind": "chart",
          "text": "Brain penetrance",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Vertical bar chart",
              "slug": "bar-vertical",
              "status": "active",
              "canonId": "019de52c-fe9d-70f2-b3b7-a9ae294f5917",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-vertical",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.361+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "92a09a1c-bad1-4aa3-957e-075507882c94",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.65,
            "w": 0.32,
            "x": 0.39,
            "y": 0.22
          },
          "kind": "chart",
          "text": "Avoiding EGFR inhibition",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Vertical bar chart",
              "slug": "bar-vertical",
              "status": "active",
              "canonId": "019de52c-fe9d-70f2-b3b7-a9ae294f5917",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-vertical",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.361+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a4a7920d-7386-4f70-9c3a-4c3ad8935137",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.65,
            "w": 0.32,
            "x": 0.07,
            "y": 0.22
          },
          "kind": "chart",
          "text": "In vitro activity, HER2 and HER2ex20",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Dot plot",
              "slug": "dot",
              "status": "active",
              "canonId": "019de52d-0235-738b-bd2b-78f8e24d7cb0",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "dot",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.361+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "943b1b93-8651-4d62-b60e-306c4d3e5bf6",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.86,
            "x": 0.07,
            "y": 0.88
          },
          "kind": "source-note",
          "text": "IC50, half-maximal inhibitory concentration; PO, orally; Head-to-head clinical studies comparing NVL-330 with currently approved or investigational therapies have not been conducted. Above data from preclinical studies. Source: Andrews K.L. et al., EORTC-NCI-AACR 2022.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.361+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6cf89f62-a901-4610-adf9-7042c91a26f5",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.86,
            "x": 0.07,
            "y": 0.06
          },
          "kind": "title",
          "text": "Preclinical | NVL-330 is a Brain Penetrant, HER2ex20-Selective Kinase Inhibitor with Potential to Avoid Adverse Events Related to EGFR Inhibition",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:03.361+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "8c196a23-c68b-40f9-ac8d-c350e198f78e",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "bfab4e5e-bb73-4f97-af91-21c76f0d5795",
          "evidence": "chart/dot: In vitro activity, HER2 and HER2ex20",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.371048+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 30,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        },
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "2c4c0c1e-c150-4077-823d-aa1cd5be85c7",
          "evidence": "chart/bar-vertical: Avoiding EGFR inhibition",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.406118+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 30,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        },
        {
          "tool": {
            "name": "Chart Selection Guide",
            "slug": "chart-selection-guide",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-b1a0-700b-ba17-0e16c4d5bcae",
            "version": 1,
            "bodyDocId": null,
            "description": "Choosing the right chart type for your data and message",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Designer",
          "layer": "slide",
          "agents": [
            "Designer"
          ],
          "matchId": "8d555d63-06a5-435f-ae04-2803af6a89ba",
          "evidence": "chart/bar-vertical: Brain penetrance",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-17 00:13:52.440706+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 30,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 31,
      "type": "setup",
      "title": "Slide 31 of a corporate presentation.",
      "function": "summarize",
      "rawType": "key_messages",
      "block": null,
      "metadata": {
        "slideType": "key_messages",
        "slideTypeCanon": {
          "name": "Key messages",
          "slug": "key_messages",
          "status": "active",
          "canonId": "019de52d-0712-703f-89f5-bda6688faf3f",
          "version": 1,
          "description": null
        },
        "function": "summarize",
        "functionCanon": {
          "name": "Summarize",
          "slug": "summarize",
          "status": "active",
          "canonId": "019de52d-1541-704f-b86f-bf7b75056373",
          "version": 1,
          "description": null
        },
        "density": "overcrowded",
        "densityScore": 77,
        "componentCount": 7,
        "textChars": 847,
        "nDataPoints": 0,
        "notes": "Slide 31 of a corporate presentation.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:23:07.58+00",
          "seconds": 6.908,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/31",
        "deck": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
        "deckAnchor": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-31",
        "deckJson": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.6,
            "w": 0.3,
            "x": 0.65,
            "y": 0.15
          },
          "kind": "image",
          "text": "3D molecular structure rendering",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Illustration",
              "slug": "illustration",
              "status": "active",
              "canonId": "019de52c-fe76-7772-a5ac-c0b7294d7615",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "illustration",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "949200af-a3ef-4846-973c-ceafe14e8872",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.25,
            "x": 0.07,
            "y": 0.12
          },
          "kind": "image",
          "text": "Nuvalent logo",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Logo",
              "slug": "logo",
              "status": "active",
              "canonId": "019de52c-fdaf-743d-94c4-d7c6a0e55302",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "logo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e35783d8-359a-4f33-8e67-294e604cbe68",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.55,
            "x": 0.08,
            "y": 0.61
          },
          "kind": "list",
          "text": "2022 operational focus on efficient conduct of concurrent Phase 1/2 clinical trials. Preliminary data from dose-escalation portion of Phase 1/2 ARROS-1 study presented at EORTC-NCI-AACR 2022. Phase 1/2 ALKOVE-1 study initiated with Phase 1 enrollment ongoing.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b65f6786-5312-46ea-8931-f76c0e529052",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.55,
            "x": 0.08,
            "y": 0.38
          },
          "kind": "list",
          "text": "Innovative molecular structures with the potential to overcome the dual challenges of kinase resistance and selectivity in the CNS and in the periphery. Potential for differentiated inhibition of proven kinase targets with opportunities for clinical utility earlier in the treatment paradigm.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "fa61879e-519a-4770-938e-ebccb031f28d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.4,
            "x": 0.08,
            "y": 0.57
          },
          "kind": "paragraph",
          "text": "Parallel lead programs in ROS1-positive and ALK-positive NSCLC:",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "109b3465-34c6-4007-bc54-02fb6958f7bc",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.55,
            "x": 0.08,
            "y": 0.8
          },
          "kind": "paragraph",
          "text": "Robust development pipeline leveraging established approach: NVL-330 selected as new development candidate for HER2ex20-positive tumors",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cd33c3c1-10f1-471f-8147-770ff1e0daa7",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.45,
            "x": 0.08,
            "y": 0.28
          },
          "kind": "title",
          "text": "PRECISELY Targeted Therapies for patients with cancer",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:23:07.58+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "837676f2-383b-4536-9524-b08f14416819",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "List presentation",
            "slug": "list-presentation",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
            "version": 1,
            "bodyDocId": null,
            "description": "Bulleted, numbered, or checklist enumerations.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "780be429-fee1-4d20-900b-b2bc55a88afc",
          "evidence": "list/bullet: Innovative molecular structures with the potential to overcome the dual challenges of kinase resistance and selectivity in the CNS and in the periphery",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-07-17 00:13:52.509956+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 31,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    }
  ],
  "arcBeats": [
    {
      "from": 6,
      "to": 6,
      "label": "Problem",
      "description": "Slide 6: Overcoming Kinase Selectivity in NSCLC"
    },
    {
      "from": 7,
      "to": 7,
      "label": "Solution",
      "description": "Slide 7: NVL-520 for ROS1-Positive Advanced NSCLC and other Solid Tumors"
    },
    {
      "from": 24,
      "to": 24,
      "label": "Market Size",
      "description": "Slide 24: Nuvalent Pipeline – Ongoing Programs"
    }
  ],
  "loops": [
    {
      "from": 6,
      "to": 16,
      "label": "Cost Of Inaction",
      "description": "What is the cost of not developing effective treatments for cancer patients with specific genetic mutations?"
    }
  ]
}