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There is not necessarily any particular SSRI preferred. SSRIs, however, only provide modest efficacy.", "attrs": null, "canon": { "kind": { "name": "List", "slug": "list", "status": "active", "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2", "version": 1, "description": "Bullet or numbered list." }, "tool": null, "subkind": { "name": "Bullet list", "slug": "bullet", "status": "active", "canonId": "019de52c-fc98-7169-a083-5cab805076ca", "version": 1, "description": null }, "framework": null }, "subkind": "bullet", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 12:26:57.374+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "7550516c-9faa-4864-941b-557ba6b53133", "parentComponentId": null }, { "bbox": { "h": 0.35, "w": 0.48, "x": 0.48, "y": 0.53 }, "kind": "list", "text": "Benzodiazepines and beta blockers can be used as standalone PRN treatments. There are widely mixed views on benzos. Beta-blockers are also a PRN option for more work/performance-related needs.", "attrs": null, "canon": { "kind": { "name": "List", "slug": "list", "status": "active", "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2", "version": 1, "description": "Bullet or numbered list." }, "tool": null, "subkind": { "name": "Bullet list", "slug": "bullet", "status": "active", "canonId": "019de52c-fc98-7169-a083-5cab805076ca", "version": 1, "description": null }, "framework": null }, "subkind": "bullet", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 12:26:57.374+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "7c913cbc-dbb8-4b77-bfeb-0a6a2cee3cab", "parentComponentId": null }, { "bbox": { "h": 0.05, "w": 0.5, "x": 0.15, "y": 0.94 }, "kind": "source-note", "text": "Abbreviations: SSRI - selective serotonin reuptake inhibitor, SNRI: serotonin norepinephrine reuptake inhibitor. Source: UpToDate; Bluestar Primary Physician Interviews (n=13, March 2022)", "attrs": null, "canon": { "kind": { "name": "Source note", "slug": "source-note", "status": "active", "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948", "version": 1, "description": "Attribution / source / caveat placed at the slide footer. 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"w": 0.52, "x": 0.04, "y": 0.22 }, "kind": "list", "text": "Physicians are desperate for innovation in anxiety and are highly enthusiastic about having a novel mechanism of action. They are less focused on the specifics of the 210 MOA and rather focus on the fact that it is not another 'me too' SSRI or benzo.\nThe clean safety and side-effect profile of BNC210 is a strong differentiator from all currently approved SAD drug classes.\nThe PRN efficacy of BNC210 being similar to benzos is encouraging to physicians, as benzos are viewed as highly effective in social anxiety.\nRapid onset of action is viewed as a strong positive as benzos are the only products that work on traditional social anxiety (as opposed to performance-specific issues). 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It's everything I told you that I wanted.\" - Psychiatrist, MI", "attrs": null, "canon": { "kind": { "name": "Quote", "slug": "quote", "status": "active", "canonId": "019de52c-f8fb-751e-8bc6-d58e2d59562a", "version": 1, "description": "Pull quote or testimonial." }, "tool": null, "subkind": { "name": "Testimonial", "slug": "testimonial", "status": "active", "canonId": "019de52c-fc21-71b6-9ac3-8266a64945e8", "version": 1, "description": null }, "framework": null }, "subkind": "testimonial", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 12:27:02.987+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "386645f7-783c-445a-bd91-c65b34b374c4", "parentComponentId": null }, { "bbox": { "h": 0.13, "w": 0.34, "x": 0.62, "y": 0.23 }, "kind": "quote", "text": "\"This product is interesting because it has a unique MOA, and it is not another 'me too' SSRI or benzo. No substance use is a big plus.\" - Psychiatrist, TX", "attrs": null, "canon": { "kind": { "name": "Quote", "slug": "quote", "status": "active", "canonId": "019de52c-f8fb-751e-8bc6-d58e2d59562a", "version": 1, "description": "Pull quote or testimonial." }, "tool": null, "subkind": { "name": "Testimonial", "slug": "testimonial", "status": "active", "canonId": "019de52c-fc21-71b6-9ac3-8266a64945e8", "version": 1, "description": null }, "framework": null }, "subkind": "testimonial", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 12:27:02.987+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "58499235-1027-4662-80af-812708f12a9d", "parentComponentId": null }, { "bbox": { "h": 0.13, "w": 0.34, "x": 0.62, "y": 0.73 }, "kind": "quote", "text": "\"Finally we could have something new to offer to our patients! The last thing we had was buspar in the 80's. No one is touching anxiety, and it's huge.\" - Psychiatrist, TN", "attrs": null, "canon": { "kind": { "name": "Quote", "slug": "quote", "status": "active", "canonId": "019de52c-f8fb-751e-8bc6-d58e2d59562a", "version": 1, "description": "Pull quote or testimonial." }, "tool": null, "subkind": { "name": "Testimonial", "slug": "testimonial", "status": "active", "canonId": "019de52c-fc21-71b6-9ac3-8266a64945e8", "version": 1, "description": null }, "framework": null }, "subkind": "testimonial", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 12:27:02.987+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "c3c20e7f-098e-4a6a-884f-cdcde0094637", "parentComponentId": null }, { "bbox": { "h": 0.15, "w": 0.34, "x": 0.62, "y": 0.53 }, "kind": "quote", "text": "\"This is a totally different MOA. I think we have 12 SSRIs already. 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Soyka M. Treatment of Benzodiazepine Dependence. N Engl J Med. 2017 Mar 23;376(12):1147-1157\n2. Frishman WH. Beta-adrenergic blocker withdrawal. Am J Cardiol. 1987 May 15;59(13):26F-32F.\n3. Fava GA, et al., Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review. Psychother Psychosom. 2015;84(2):72-81.\n4. Fava GA, et al., Withdrawal Symptoms after Serotonin-Noradrenaline Reuptake Inhibitor Discontinuation: Systematic Review. Psychother Psychosom. 2018;87(4):195-203\n5. Liu L, et al.,The Effects of Benzodiazepine Use and Abuse on Cognition in the Elders: A Systematic Review and Meta-Analysis of Comparative Studies. Front Psychiatry. 2020 Sep 17;11:00755.\n6. Dodds TJ. Prescribed Benzodiazepines and Suicide Risk: A Review of the Literature. 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