{
  "schemaVersion": "deck-intelligence.v1",
  "id": "019de073-9e32-71bd-acba-301a2d9cbf00",
  "slug": "d469b8223f6f86cb5d6a1f0a99cbce5c",
  "title": "Aeglea BioTherapeutics | Investor Day Presentation Deck | 28 slides",
  "subtitle": "Aeglea BioTherapeutics · 2022-10",
  "author": "Aeglea BioTherapeutics",
  "date": "2022-10-01 00:00:00",
  "pageCount": 28,
  "kind": "conference-presentation",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "document": {
    "id": "019de073-9e32-71bd-acba-301a2d9cbf00",
    "slug": "d469b8223f6f86cb5d6a1f0a99cbce5c",
    "title": "Aeglea BioTherapeutics | Investor Day Presentation Deck | 28 slides",
    "rawTitle": "Aeglea BioTherapeutics | Investor Day Presentation Deck | 28 slides",
    "authorId": "aeglea-biotherapeutics",
    "authorName": "Aeglea BioTherapeutics",
    "authorDisplay": "Aeglea BioTherapeutics",
    "kind": {
      "slug": "conference-presentation",
      "label": "Conference presentation"
    },
    "sourceType": {
      "slug": "investor_relations",
      "label": "Investor relations"
    },
    "fileName": "2022-10__aeglea-biotherapeutics__investor-day__d469b822.pdf",
    "sourceUrl": "https://www.slidebook.io/company/aeglea-biotherapeutics/presentation/d469b8223f6f86cb5d6a1f0a99cbce5c/",
    "sourceDate": "2022-10-15 00:00:00",
    "presentationDate": "2022-10-01 00:00:00",
    "ingestedAt": "2026-04-30 22:12:46.874614+00",
    "status": "ready",
    "pageCount": 28,
    "orientation": "landscape",
    "aspectRatio": 1.7777778,
    "targetCompany": null,
    "targetTicker": null,
    "metadata": {
      "corpus": "slidebook",
      "industry": "biotechnology",
      "local_root": "/Users/miguelsuredasuau/Desktop/lalalalla/_scrape/slidebook/decks/2022-10__aeglea-biotherapeutics__investor-day__d469b822",
      "image_width": 1920,
      "image_format": "jpg",
      "deck_type_raw": "Investor Day Presentation Deck",
      "deck_type_slug": null,
      "source_url_pattern": "https://www.slidebook.io/company/{company_slug}/presentation/{deck_id}/"
    }
  },
  "coverage": {
    "pageCount": 28,
    "pagesIndexed": 28,
    "pagesWithImages": 28,
    "pagesWithMetadata": 28,
    "imageCoveragePct": 100,
    "metadataCoveragePct": 100,
    "componentCount": 112,
    "chartCount": 3,
    "metricSlides": 0,
    "toolMatches": 9,
    "documentToolMatches": 0,
    "frameworkMatches": 6,
    "arcMatches": 1,
    "beatMatches": 3,
    "loopMatches": 2,
    "patternMatches": 0,
    "storymakersMatch": false,
    "scoreAvailable": false,
    "reviewAvailable": false,
    "activistThesisAvailable": false,
    "pitchdeckMetadataAvailable": false,
    "pitchdeckProfileAvailable": false
  },
  "blocks": [],
  "matches": {
    "arcs": [
      {
        "arc": {
          "name": "Problem-Agitate-Solution",
          "slug": "problem-agitate-solution",
          "status": "active",
          "bestFor": "Sales pitches, urgency-driven, competitive displacement",
          "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
        "evidence": "The deck follows a clear problem-agitate-solution structure, highlighting the disease burden, current limitations, and the proposed treatment",
        "isPrimary": true,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-16 22:26:49.845961+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": "doc-narrative-v1"
        }
      }
    ],
    "beats": [
      {
        "to": 10,
        "arc": {
          "name": "Problem-Agitate-Solution",
          "slug": "problem-agitate-solution",
          "status": "active",
          "bestFor": "Sales pitches, urgency-driven, competitive displacement",
          "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "from": 7,
        "name": "Problem (Identify pain)",
        "beatId": "dfc95667-9e06-43c4-ab5b-f60c317fa5c8",
        "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
        "beatType": {
          "name": "Problem (Identify pain)",
          "slug": "problem-agitate-solution-problem-identify-pain",
          "status": "active",
          "canonId": "019dd9b8-0e78-74bb-b8f6-54348367a131",
          "version": 1,
          "description": null
        },
        "evidence": "Slides 7-10 provide an overview of Classical HCU, its clinical severity, and current clinical guidelines",
        "position": 0,
        "isPrimaryArc": true,
        "parentBeatType": {
          "name": "Complication",
          "slug": "complication",
          "status": "active",
          "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
          "version": 1,
          "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
        },
        "alignedBlockIds": null,
        "matchConfidence": 0.8
      },
      {
        "to": 14,
        "arc": {
          "name": "Problem-Agitate-Solution",
          "slug": "problem-agitate-solution",
          "status": "active",
          "bestFor": "Sales pitches, urgency-driven, competitive displacement",
          "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "from": 11,
        "name": "Agitate (Make it worse)",
        "beatId": "e2d18a2e-d898-4d6e-9bf1-62eefe35ed84",
        "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
        "beatType": {
          "name": "Agitate (Make it worse)",
          "slug": "problem-agitate-solution-agitate-make-it-worse",
          "status": "active",
          "canonId": "019dd9b8-0f5a-71dd-bae7-8fadb0d09456",
          "version": 1,
          "description": null
        },
        "evidence": "Slides 11-14 highlight the diagnostic delay, risk of misdiagnosis, and current management limitations",
        "position": 1,
        "isPrimaryArc": true,
        "parentBeatType": {
          "name": "Development",
          "slug": "development",
          "status": "active",
          "canonId": "019dd9b8-0332-7008-b3aa-11b0840a57b1",
          "version": 1,
          "description": "The middle stretch in arcs that have one. Often where length problems creep in."
        },
        "alignedBlockIds": null,
        "matchConfidence": 0.8
      },
      {
        "to": 24,
        "arc": {
          "name": "Problem-Agitate-Solution",
          "slug": "problem-agitate-solution",
          "status": "active",
          "bestFor": "Sales pitches, urgency-driven, competitive displacement",
          "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
          "version": 1,
          "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
          "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
          "description": null,
          "familyLabel": null,
          "categoryName": "Strategy & Business",
          "categorySlug": "strategy-business"
        },
        "from": 20,
        "name": "Solution (Provide relief)",
        "beatId": "5fa22bc5-87f2-4946-9705-fa014d063ae3",
        "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
        "beatType": {
          "name": "Solution (Provide relief)",
          "slug": "problem-agitate-solution-solution-provide-relief",
          "status": "active",
          "canonId": "019dd9b8-0fee-73e9-9ae5-799c7f3895cd",
          "version": 1,
          "description": null
        },
        "evidence": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach",
        "position": 2,
        "isPrimaryArc": true,
        "parentBeatType": {
          "name": "Resolution",
          "slug": "resolution",
          "status": "active",
          "canonId": "019dd9b8-045d-703b-8dd7-e92aba3ba91b",
          "version": 1,
          "description": "How the deck ends. Required in 19/20 arcs. The exception (Sparkline) ends with new bliss which is functionally a resolution."
        },
        "alignedBlockIds": null,
        "matchConfidence": 0.8
      }
    ],
    "loops": [
      {
        "to": 14,
        "from": 11,
        "loop": {
          "name": "27_cost_of_inaction",
          "slug": "27-cost-of-inaction",
          "status": "active",
          "bestFor": "Urgent budget requests, compliance, risk mitigation",
          "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
          "version": 1,
          "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
          "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
          "description": "Quantify what happens if the audience does nothing",
          "familyLabel": null,
          "categoryName": "Urgency",
          "categorySlug": "urgency"
        },
        "matchId": "946aef3a-76bb-47e2-a4de-02631e3ad727",
        "evidence": "The deck emphasizes the burden of disease and limitations of current management",
        "position": 0,
        "objective": "Highlight the cost of inaction for Classical HCU patients",
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-16 22:26:49.983636+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": "doc-narrative-v1"
        }
      },
      {
        "to": 24,
        "from": 20,
        "loop": {
          "name": "53_jobs_to_be_done",
          "slug": "53-jobs-to-be-done",
          "status": "active",
          "bestFor": "Product innovation, market entry, competitive positioning",
          "canonId": "019dd956-7b6c-7594-b5b3-eecbe0ab48e8",
          "version": 1,
          "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
          "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
          "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying",
          "familyLabel": null,
          "categoryName": "Consulting Framework",
          "categorySlug": "consulting-framework"
        },
        "matchId": "8d7561ed-879a-4cee-9208-d194f7670c57",
        "evidence": "The deck presents Pegtarviliase as a potential best-in-class treatment",
        "position": 1,
        "objective": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients",
        "confidence": 0.6,
        "extraction": {
          "at": "2026-07-16 22:26:50.017864+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": "doc-narrative-v1"
        }
      }
    ],
    "tools": [
      {
        "tool": {
          "name": "Slide recipe: Cover",
          "slug": "cover-slide",
          "status": "active",
          "bestFor": null,
          "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
          "version": 1,
          "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
          "description": "The first ten seconds. Build it deliberately.",
          "familyLabel": "slide-recipe",
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "designer",
        "layer": "slide",
        "agents": [
          "designer"
        ],
        "matchId": "df7252d5-05b4-4b56-8fff-9d4debff974a",
        "evidence": "KOL Webinar on Classical Homocystinuria and Pegtarviliase",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:11:18.600176+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 1,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Authority citation",
          "slug": "authority-citation",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-49ae-7557-89ad-3fca70469b45",
          "version": 1,
          "bodyDocId": null,
          "description": "Quoting an authority figure, study, or precedent to lend weight.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "0900b9d9-1b78-4f57-9b96-4cb938c6f06e",
        "evidence": "Dr. Harvey Levy, Senior Physician in Medicine/Genetics, Boston Children’s Hospital & Professor of Pediatrics, Harvard Medical School",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 00:11:18.712606+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 3,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Action Titles",
          "slug": "action-titles",
          "status": "active",
          "bestFor": "Any decision-grade deliverable — strategy recommendation, board update, investment memo, M&A review, post-mortem — where the reader is being asked to agree, decide, or act and will skim the title bar at speed.",
          "canonId": "019dd956-ac70-700b-a608-ba58e78f5dcc",
          "version": 1,
          "bodyDocId": "816dad3c-9983-41c1-a86e-978ebd582841",
          "description": "The McKinsey-bred discipline of writing every slide title as a complete declarative sentence with a verb and an insight, not a topic label. Each title is a sub-claim that ladders up to the deck's governing thought; read in sequence, the titles reconstruct the executive summary.",
          "familyLabel": null,
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "Architect",
        "layer": "slide",
        "agents": [
          "Architect"
        ],
        "matchId": "25604a0d-0753-4fa6-a481-0d94feaa8104",
        "evidence": "Building an Enzyme Therapy Company to Serve Patients and Drive Near and Long-Term Growth",
        "pageRefs": null,
        "priority": "Core",
        "whenToUse": "Any decision-grade deliverable — strategy recommendation, board update, investment memo, M&A review, post-mortem — where the reader is being asked to agree, decide, or act and will skim the title bar at speed.",
        "confidence": 0.8,
        "extraction": {
          "at": "2026-07-17 00:11:18.792115+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 4,
        "whyItWorks": "Solves two failure modes at once. (1) The buried claim: action titles place the conclusion on the page before any analysis is read, so a busy reader doesn't reverse-engineer it from the chart. (2) The spineless deck: because each title is a claim, slides have to ladder up to the governing thought; logical gaps become visible as topic-shaped titles in a sequence that no longer reads as a story.",
        "antipattern": "Topic labels disguised as titles — Volume by quarter, Key findings, Pricing strategy, Margins have been impacted. No verb, or a passive verb with no agent, or a fact (Revenue grew 12%) without the so-what. Also: titles that overreach the chart's evidence, multi-claim X-grew-but-Y-fell welded titles, and mechanical repetition of the same X-drove-Y template across the deck.",
        "cardinality": null,
        "narrativePurpose": "Forces the deck to carry its argument in the title bar so a senior reader can extract the recommendation without opening a single slide; converts a binder of topics into a navigable pyramid where every slide is a node defending the apex."
      },
      {
        "tool": {
          "name": "List presentation",
          "slug": "list-presentation",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
          "version": 1,
          "bodyDocId": null,
          "description": "Bulleted, numbered, or checklist enumerations.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "e28866a0-08eb-4b93-ac27-ac2c19ce776b",
        "evidence": "list/bullet: Pioneering Bold Science",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 00:11:18.831421+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 4,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Table data",
          "slug": "table-data",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-4fab-7168-a82f-b847350a006d",
          "version": 1,
          "bodyDocId": null,
          "description": "Tabular layouts of structured data.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "7f8e1473-32cf-4f8f-ab7d-1238bd6d536c",
        "evidence": "table/data: Pipeline table",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 00:11:18.910568+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 5,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Slide recipe: Cover",
          "slug": "cover-slide",
          "status": "active",
          "bestFor": null,
          "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
          "version": 1,
          "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
          "description": "The first ten seconds. Build it deliberately.",
          "familyLabel": "slide-recipe",
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "designer",
        "layer": "slide",
        "agents": [
          "designer"
        ],
        "matchId": "4c6eac70-cd03-4672-bcdf-4abeb6dde5ab",
        "evidence": "Classical Homocystinuria: 50 Years of Experience",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:11:18.987053+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 6,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "2x2 matrix",
          "slug": "matrix-2x2",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd9e1-50ab-72d1-8afb-3ab0a38e32a8",
          "version": 1,
          "bodyDocId": null,
          "description": "BCG matrix, importance/urgency, any axes-and-quadrants frame.",
          "familyLabel": null,
          "categoryName": null,
          "categorySlug": null
        },
        "agent": null,
        "layer": "slide",
        "agents": null,
        "matchId": "f58e1f6e-d33f-4aa8-a797-51de0d271884",
        "evidence": "This slide includes a pie chart showing Classical HCU by B6 Responsiveness, which can be interpreted as a 2x2 matrix.",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 03:57:40.93429+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 21,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": "common",
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Problem Statement Canvas",
          "slug": "problem-statement-canvas",
          "status": "active",
          "bestFor": null,
          "canonId": "019dd956-839d-744b-ad11-9bf3e3642a18",
          "version": 1,
          "bodyDocId": null,
          "description": "Structured definition of the problem: What? Who? Where? When? Scale?",
          "familyLabel": null,
          "categoryName": "Block",
          "categorySlug": "block"
        },
        "agent": "Architect",
        "layer": "slide",
        "agents": [
          "Architect"
        ],
        "matchId": "e0ba1fc4-6a30-49b7-a68b-846a58bfde41",
        "evidence": "Depiction of Normal and Therapeutic Metabolism",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.7,
        "extraction": {
          "at": "2026-07-17 00:11:34.869901+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 24,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      },
      {
        "tool": {
          "name": "Slide recipe: Cover",
          "slug": "cover-slide",
          "status": "active",
          "bestFor": null,
          "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
          "version": 1,
          "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
          "description": "The first ten seconds. Build it deliberately.",
          "familyLabel": "slide-recipe",
          "categoryName": "Slide",
          "categorySlug": "slide"
        },
        "agent": "designer",
        "layer": "slide",
        "agents": [
          "designer"
        ],
        "matchId": "cbc2742e-5bf2-4248-82d5-523a5f68db01",
        "evidence": "805 Las Cimas Parkway Suite 100 Austin, TX 78746 aeglea.com",
        "pageRefs": null,
        "priority": null,
        "whenToUse": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-07-17 00:11:35.097256+00",
          "model": "or:meta-llama/llama-4-scout",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 28,
        "whyItWorks": null,
        "antipattern": null,
        "cardinality": null,
        "narrativePurpose": null
      }
    ],
    "frameworks": [
      {
        "matchId": "1df117ff-ed19-4e26-830a-16ea4bfd0fb4",
        "evidence": "Horizontal bars representing development phases over time",
        "framework": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-05-02 12:27:48.379+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 5,
        "frameworkName": "gantt-chart"
      },
      {
        "matchId": "e3fbb6e0-3714-4bb6-b778-5cb4162afa02",
        "evidence": "The diagram maps the disease (Classical HCU) to its clinical manifestations (phenotypes).",
        "framework": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-05-02 12:27:46.834+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 7,
        "frameworkName": "causal-chain"
      },
      {
        "matchId": "e52101cb-d7bf-4242-99d4-9bd071bd3445",
        "evidence": "The slide describes the sequence of events from enzyme defect to accumulation to cellular interference.",
        "framework": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-05-02 15:31:35.691+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 8,
        "frameworkName": "causal-chain"
      },
      {
        "matchId": "7339e024-c5ac-4dc5-bcf7-d50b400cc8bf",
        "evidence": "The slide uses a table to compare symptoms between two conditions to illustrate diagnostic confusion.",
        "framework": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-05-02 12:27:47.637+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 12,
        "frameworkName": "comparison_frame"
      },
      {
        "matchId": "b8bef4a3-479f-445e-a4e8-f3c258165496",
        "evidence": "The slide maps the biochemical pathway from dietary protein to homocysteine accumulation and the subsequent therapeutic intervention.",
        "framework": null,
        "confidence": 0.9,
        "extraction": {
          "at": "2026-05-02 12:27:49.181+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 23,
        "frameworkName": "causal-chain"
      },
      {
        "matchId": "5df9b9d5-5c79-4d52-be4b-db6d5e7f87eb",
        "evidence": "The slide outlines a sequential clinical trial design.",
        "framework": null,
        "confidence": 0.8,
        "extraction": {
          "at": "2026-05-02 12:27:49.88+00",
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "seconds": null,
          "promptVersion": null
        },
        "pageNumber": 25,
        "frameworkName": "process"
      }
    ],
    "patterns": []
  },
  "storymakers": null,
  "score": null,
  "review": null,
  "activistThesis": null,
  "pitchdeck": {
    "metadata": null,
    "profile": null
  },
  "slides": [
    {
      "page": 1,
      "type": "setup",
      "function": "front_matter",
      "imagePath": "https://imgproxy.kitesheet.com/LgicWlr838avwb3vUz46ewqqIPTJbdCDfZdO3b1cihQ/rs:fit:1200:1200:0/q:82/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9kNDY5YjgyMjNmNmY4NmNiNWQ2YTFmMGE5OWNiY2U1Yy9wMDAxLmpwZw",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 24,
        "componentCount": 4,
        "textChars": 112,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:46.589+00",
          "seconds": 2.669,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/1",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-1",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.06,
            "w": 0.18,
            "x": 0.708,
            "y": 0.16
          },
          "kind": "image",
          "text": "aeglea",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Logo",
              "slug": "logo",
              "status": "active",
              "canonId": "019de52c-fdaf-743d-94c4-d7c6a0e55302",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "logo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.589+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7f23f636-e35e-435f-8857-f8bef94be210",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.1,
            "x": 0.083,
            "y": 0.88
          },
          "kind": "paragraph",
          "text": "Nasdaq: AGLE",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.589+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ec85e873-53bb-4355-ab43-24d628e47b55",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.6,
            "x": 0.08,
            "y": 0.37
          },
          "kind": "title",
          "text": "KOL Webinar on Classical Homocystinuria and Pegtarviliase",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.589+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a3350d67-9467-4a50-ac38-04311e70861b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.4,
            "x": 0.08,
            "y": 0.58
          },
          "kind": "title",
          "text": "Aeglea BioTherapeutics – October 2022",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "019de52c-fb09-739d-900c-815b0d9ac526",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "subtitle",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.589+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "0bd35b04-45d2-4a01-83b4-1c91bbd02af1",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Slide recipe: Cover",
            "slug": "cover-slide",
            "status": "active",
            "bestFor": null,
            "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
            "version": 1,
            "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
            "description": "The first ten seconds. Build it deliberately.",
            "familyLabel": "slide-recipe",
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "designer",
          "layer": "slide",
          "agents": [
            "designer"
          ],
          "matchId": "df7252d5-05b4-4b56-8fff-9d4debff974a",
          "evidence": "KOL Webinar on Classical Homocystinuria and Pegtarviliase",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:11:18.600176+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 1,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "thumbSrc": "https://imgproxy.kitesheet.com/Ormhpv2HFdFhbq7NYkb_9Kcvr0eI7LTSnmdxBLRTnyU/rs:fit:480:480:0/q:78/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9kNDY5YjgyMjNmNmY4NmNiNWQ2YTFmMGE5OWNiY2U1Yy9wMDAxLmpwZw",
      "imagePathAlt": "https://imgproxy.kitesheet.com/rwUQ9P4nFAivOjIUkXdGDBk-2pxIQS4F1GMq1CX5M2E/rs:fit:1200:1200:0/q:82/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9kNDY5YjgyMjNmNmY4NmNiNWQ2YTFmMGE5OWNiY2U1Yy9wMDAxLnBuZw",
      "thumbSrcAlt": "https://imgproxy.kitesheet.com/fOX4Jvn-p9tfwvnwia9-R_PopgJRFWDvK0tdMlQKVSc/rs:fit:480:480:0/q:78/f:webp/czM6Ly9raXRlc2hlZXQvY29ycHVzL3NsaWRlcy9kNDY5YjgyMjNmNmY4NmNiNWQ2YTFmMGE5OWNiY2U1Yy9wMDAxLnBuZw"
    },
    {
      "page": 2,
      "type": "setup",
      "title": "Includes a specific disclosure regarding Dr. Harvey Levy's role as a Principal Investigator and Consultant.",
      "function": "front_matter",
      "rawType": "disclaimer",
      "block": null,
      "metadata": {
        "slideType": "disclaimer",
        "slideTypeCanon": {
          "name": "Disclaimer",
          "slug": "disclaimer",
          "status": "active",
          "canonId": "019de52d-0801-727b-b98a-5ed095aeee78",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 35,
        "componentCount": 3,
        "textChars": 492,
        "nDataPoints": 0,
        "notes": "Includes a specific disclosure regarding Dr. Harvey Levy's role as a Principal Investigator and Consultant.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:46.879+00",
          "seconds": 2.908,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/2",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-2",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.75,
            "w": 0.864,
            "x": 0.068,
            "y": 0.148
          },
          "kind": "disclaimer",
          "text": "This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management...",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.879+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7fc9da10-9c4b-4e2e-bf12-438b686f07a3",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.038,
            "w": 0.864,
            "x": 0.068,
            "y": 0.895
          },
          "kind": "paragraph",
          "text": "Dr. Harvey Levy is the Principal Investigator of the Boston site for the clinical trial of an enzyme replacement therapy for Homocystinuria sponsored by Travere and is Consultant to Aeglea on their clinical trial of a human enzyme therapy for Homocystinuria.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.879+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ee9df878-2a08-4f0d-ba67-fdc517286ae1",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.038,
            "w": 0.335,
            "x": 0.068,
            "y": 0.048
          },
          "kind": "title",
          "text": "Forward Looking Statements",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.879+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "747733c8-f0b6-42a9-ada3-7ca6b2854a2c",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 3,
      "type": "setup",
      "function": "introduce_nominees",
      "rawType": "nominee_bio",
      "block": null,
      "metadata": {
        "slideType": "nominee_bio",
        "slideTypeCanon": {
          "name": "Nominee bio",
          "slug": "nominee_bio",
          "status": "active",
          "canonId": "019de52d-1136-70ae-861a-f546f0c9d1ef",
          "version": 1,
          "description": null
        },
        "function": "introduce_nominees",
        "functionCanon": {
          "name": "Introduce nominees",
          "slug": "introduce_nominees",
          "status": "active",
          "canonId": "019de52d-1833-77fe-ac47-5f26d823a84a",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 59,
        "componentCount": 4,
        "textChars": 1107,
        "nDataPoints": 3,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:51.369+00",
          "seconds": 7.339,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/3",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-3",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.472,
            "w": 0.212,
            "x": 0.104,
            "y": 0.22
          },
          "kind": "image",
          "text": null,
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Headshot",
              "slug": "headshot",
              "status": "active",
              "canonId": "019de52c-fd5f-765c-9282-38b54f61bbbf",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headshot",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.369+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "8b90d762-5971-410d-87ac-cc3a223a2b35",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.22,
            "w": 0.53,
            "x": 0.367,
            "y": 0.22
          },
          "kind": "paragraph",
          "text": "Dr. Levy has been involved in metabolic diseases for over 50 years. He established the Metabolic Program at the Boston Children’s Hospital in 1978 and it has become one of the world’s premier such programs. The program was recently named in his honor and the Director of the program is given the title of the Harvey L. Levy Chair in Metabolic Disorders. Dr. Levy has published almost 500 articles on metabolic disease and numerous chapters in classical metabolic texts as well as two books. He has received numerous awards and citations.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.369+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "9902faa8-66ec-4152-b0a1-b4cbe58d857b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.18,
            "w": 0.53,
            "x": 0.367,
            "y": 0.535
          },
          "kind": "paragraph",
          "text": "His interest in Homocystinuria dates to when he diagnosed the first baby identified with Homocystinuria by NBS in U.S. and one of the first worldwide. He then diagnosed the older sister born before NBS. He has followed this family for over 50 years, and has diagnosed, treated, and followed over 40 additional patients with Homocystinuria as well as consulting on numerous patients at other medical centers nationally and internationally.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.369+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "9dbb6ce3-9004-4fb4-bdc5-b5834c34a831",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.88,
            "x": 0.06,
            "y": 0.08
          },
          "kind": "title",
          "text": "Dr. Harvey Levy, Senior Physician in Medicine/Genetics, Boston Children’s Hospital & Professor of Pediatrics, Harvard Medical School",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.369+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "531ea41a-8256-4429-ba92-7df407d2cc32",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Authority citation",
            "slug": "authority-citation",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-49ae-7557-89ad-3fca70469b45",
            "version": 1,
            "bodyDocId": null,
            "description": "Quoting an authority figure, study, or precedent to lend weight.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "0900b9d9-1b78-4f57-9b96-4cb938c6f06e",
          "evidence": "Dr. Harvey Levy, Senior Physician in Medicine/Genetics, Boston Children’s Hospital & Professor of Pediatrics, Harvard Medical School",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 00:11:18.712606+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 3,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 4,
      "type": "setup",
      "function": "summarize",
      "rawType": "key_messages",
      "block": null,
      "metadata": {
        "slideType": "key_messages",
        "slideTypeCanon": {
          "name": "Key messages",
          "slug": "key_messages",
          "status": "active",
          "canonId": "019de52d-0712-703f-89f5-bda6688faf3f",
          "version": 1,
          "description": null
        },
        "function": "summarize",
        "functionCanon": {
          "name": "Summarize",
          "slug": "summarize",
          "status": "active",
          "canonId": "019de52d-1541-704f-b86f-bf7b75056373",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 49,
        "componentCount": 4,
        "textChars": 635,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:46.837+00",
          "seconds": 2.585,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/4",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-4",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.2,
            "w": 0.88,
            "x": 0.06,
            "y": 0.435
          },
          "kind": "list",
          "text": "Delivering Groundbreaking Medicines: Focused on disease modifying therapies, Strong engagement with patient communities, Efficient clinical development and commercialization model",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.837+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "14c0e647-5f02-4100-bbda-bdd162a88468",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.88,
            "x": 0.06,
            "y": 0.675
          },
          "kind": "list",
          "text": "Redefining the Possible: Novel approach to unconventional targets, High unmet need and limited competition drive significant commercial opportunity",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.837+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "64ac22be-678a-48b3-92d6-a127907b6e10",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.88,
            "x": 0.06,
            "y": 0.19
          },
          "kind": "list",
          "text": "Pioneering Bold Science: Innovative enzyme engineering platform, Differentiated product profiles, Expertise in metabolic disease and enzyme engineering creates complementary opportunities in areas with limited competition",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.837+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f2cfb3e3-635c-4cda-8e8e-443268c4865b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.8,
            "x": 0.06,
            "y": 0.05
          },
          "kind": "title",
          "text": "Building an Enzyme Therapy Company to Serve Patients and Drive Near and Long-Term Growth",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.837+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "eb964f46-14b3-4ff7-9d57-59e1ad1ce6d9",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Action Titles",
            "slug": "action-titles",
            "status": "active",
            "bestFor": "Any decision-grade deliverable — strategy recommendation, board update, investment memo, M&A review, post-mortem — where the reader is being asked to agree, decide, or act and will skim the title bar at speed.",
            "canonId": "019dd956-ac70-700b-a608-ba58e78f5dcc",
            "version": 1,
            "bodyDocId": "816dad3c-9983-41c1-a86e-978ebd582841",
            "description": "The McKinsey-bred discipline of writing every slide title as a complete declarative sentence with a verb and an insight, not a topic label. Each title is a sub-claim that ladders up to the deck's governing thought; read in sequence, the titles reconstruct the executive summary.",
            "familyLabel": null,
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "Architect",
          "layer": "slide",
          "agents": [
            "Architect"
          ],
          "matchId": "25604a0d-0753-4fa6-a481-0d94feaa8104",
          "evidence": "Building an Enzyme Therapy Company to Serve Patients and Drive Near and Long-Term Growth",
          "pageRefs": null,
          "priority": "Core",
          "whenToUse": "Any decision-grade deliverable — strategy recommendation, board update, investment memo, M&A review, post-mortem — where the reader is being asked to agree, decide, or act and will skim the title bar at speed.",
          "confidence": 0.8,
          "extraction": {
            "at": "2026-07-17 00:11:18.792115+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 4,
          "whyItWorks": "Solves two failure modes at once. (1) The buried claim: action titles place the conclusion on the page before any analysis is read, so a busy reader doesn't reverse-engineer it from the chart. (2) The spineless deck: because each title is a claim, slides have to ladder up to the governing thought; logical gaps become visible as topic-shaped titles in a sequence that no longer reads as a story.",
          "antipattern": "Topic labels disguised as titles — Volume by quarter, Key findings, Pricing strategy, Margins have been impacted. No verb, or a passive verb with no agent, or a fact (Revenue grew 12%) without the so-what. Also: titles that overreach the chart's evidence, multi-claim X-grew-but-Y-fell welded titles, and mechanical repetition of the same X-drove-Y template across the deck.",
          "cardinality": null,
          "narrativePurpose": "Forces the deck to carry its argument in the title bar so a senior reader can extract the recommendation without opening a single slide; converts a binder of topics into a navigable pyramid where every slide is a node defending the apex."
        },
        {
          "tool": {
            "name": "List presentation",
            "slug": "list-presentation",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4ef7-777d-ba68-9074c2b3bcf1",
            "version": 1,
            "bodyDocId": null,
            "description": "Bulleted, numbered, or checklist enumerations.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "e28866a0-08eb-4b93-ac27-ac2c19ce776b",
          "evidence": "list/bullet: Pioneering Bold Science",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 00:11:18.831421+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 4,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 5,
      "type": "setup",
      "title": "The slide uses a Gantt-style bar chart to represent clinical trial phases for each drug program.",
      "function": "present_framework",
      "rawType": "roadmap",
      "block": null,
      "metadata": {
        "slideType": "roadmap",
        "slideTypeCanon": {
          "name": "Roadmap",
          "slug": "roadmap",
          "status": "active",
          "canonId": "019de52d-0a55-72bc-9b7b-a47ef109839c",
          "version": 1,
          "description": null
        },
        "function": "present_framework",
        "functionCanon": {
          "name": "Present framework",
          "slug": "present_framework",
          "status": "active",
          "canonId": "019de52d-1403-7667-9100-d2ac6709f750",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 41,
        "componentCount": 4,
        "textChars": 304,
        "nDataPoints": 3,
        "notes": "The slide uses a Gantt-style bar chart to represent clinical trial phases for each drug program.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:48.379+00",
          "seconds": 4.045,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/5",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-5",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.5,
            "w": 0.35,
            "x": 0.26,
            "y": 0.25
          },
          "kind": "chart",
          "text": "Clinical development status bars for four programs",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Horizontal bar chart",
              "slug": "bar-horizontal",
              "status": "active",
              "canonId": "019de52c-fec4-7221-986b-1cb5f5e84b1f",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bar-horizontal",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.379+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "db742943-b985-4749-9f35-427ee500ac2d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.9,
            "x": 0.05,
            "y": 0.82
          },
          "kind": "source-note",
          "text": "Detailed footnotes regarding patient estimates and licensing agreements.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.379+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "019ac947-3215-4606-aef8-8c6630cf4d07",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.65,
            "w": 0.9,
            "x": 0.05,
            "y": 0.15
          },
          "kind": "table",
          "text": "Pipeline table with columns: Program, Research, Phase 1/2, Phase 3, Regulatory Review, Addressable Market, Geographic Rights",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.379+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1f329d25-6a3b-461c-b877-da54526a2d35",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.8,
            "x": 0.05,
            "y": 0.05
          },
          "kind": "title",
          "text": "Aeglea's Human Enzyme Platform for Rare Metabolic Diseases",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.379+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "43d3a7c1-e2c7-4dc2-9419-aee752af8f29",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Table data",
            "slug": "table-data",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-4fab-7168-a82f-b847350a006d",
            "version": 1,
            "bodyDocId": null,
            "description": "Tabular layouts of structured data.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "7f8e1473-32cf-4f8f-ab7d-1238bd6d536c",
          "evidence": "table/data: Pipeline table",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 00:11:18.910568+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 5,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [
        {
          "matchId": "1df117ff-ed19-4e26-830a-16ea4bfd0fb4",
          "evidence": "Horizontal bars representing development phases over time",
          "framework": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-05-02 12:27:48.379+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 5,
          "frameworkName": "gantt-chart"
        }
      ],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 6,
      "type": "setup",
      "function": "front_matter",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 14,
        "componentCount": 2,
        "textChars": 184,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:48.627+00",
          "seconds": 4.271,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/6",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-6",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.111,
            "w": 0.688,
            "x": 0.083,
            "y": 0.788
          },
          "kind": "paragraph",
          "text": "Harvey L. Levy, MD\nSenior Physician in Medicine and Genetics, Boston Children’s Hospital\nProfessor of Pediatrics, Harvard Medical School",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.627+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cad024df-08f6-4cd0-8f25-7147d79883d5",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.063,
            "w": 0.833,
            "x": 0.083,
            "y": 0.408
          },
          "kind": "title",
          "text": "Classical Homocystinuria: 50 Years of Experience",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.627+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "22e92f65-2694-4d40-a361-53d5675353a9",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Slide recipe: Cover",
            "slug": "cover-slide",
            "status": "active",
            "bestFor": null,
            "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
            "version": 1,
            "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
            "description": "The first ten seconds. Build it deliberately.",
            "familyLabel": "slide-recipe",
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "designer",
          "layer": "slide",
          "agents": [
            "designer"
          ],
          "matchId": "4c6eac70-cd03-4672-bcdf-4abeb6dde5ab",
          "evidence": "Classical Homocystinuria: 50 Years of Experience",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:11:18.987053+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 6,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 7,
      "type": "tension",
      "title": "The slide uses a hierarchical diagram to map the clinical manifestations of the disease.",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 37,
        "componentCount": 4,
        "textChars": 331,
        "nDataPoints": 0,
        "notes": "The slide uses a hierarchical diagram to map the clinical manifestations of the disease.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:46.834+00",
          "seconds": 2.289,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/7",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-7",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.86,
            "x": 0.07,
            "y": 0.35
          },
          "kind": "diagram",
          "text": "Classical HCU (CBS deficiency) Clinical Phenotype mapping to Eye, Brain, Skeletal System, and Vascular System",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Diagram",
              "slug": "diagram",
              "status": "active",
              "canonId": "019de52c-f9f0-734a-81de-15382ff28c65",
              "version": 1,
              "description": "Schematic or relational diagram."
            },
            "tool": null,
            "subkind": {
              "name": "Process flow",
              "slug": "process",
              "status": "active",
              "canonId": "019de52d-039c-718f-ad3a-efe9c4b3c838",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "process",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.834+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a2d87c5b-2296-41e7-a6fd-cb80aa92ea56",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.85,
            "x": 0.07,
            "y": 0.2
          },
          "kind": "paragraph",
          "text": "Serious inherited metabolic disorder with progressive, potentially debilitating complications1-4",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.834+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "a206bb9a-7d3b-4a7f-b12e-60bc8b5b66ad",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.96,
            "x": 0.02,
            "y": 0.88
          },
          "kind": "source-note",
          "text": "HCU, homocystinuria; also known as cystathionine β-synthase (CBS) deficiency. 1-4. References.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.834+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "eb2fb1ae-31cf-4d1d-bbd3-983565eaddd0",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.45,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Clinical Overview",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:46.834+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d7f0b8a6-226e-4043-98cc-75a6066f101f",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [
        {
          "matchId": "e3fbb6e0-3714-4bb6-b778-5cb4162afa02",
          "evidence": "The diagram maps the disease (Classical HCU) to its clinical manifestations (phenotypes).",
          "framework": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-05-02 12:27:46.834+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 7,
          "frameworkName": "causal-chain"
        }
      ],
      "arcBeats": [
        {
          "to": 10,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 7,
          "name": "Problem (Identify pain)",
          "beatId": "dfc95667-9e06-43c4-ab5b-f60c317fa5c8",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Problem (Identify pain)",
            "slug": "problem-agitate-solution-problem-identify-pain",
            "status": "active",
            "canonId": "019dd9b8-0e78-74bb-b8f6-54348367a131",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 7-10 provide an overview of Classical HCU, its clinical severity, and current clinical guidelines",
          "position": 0,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Complication",
            "slug": "complication",
            "status": "active",
            "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
            "version": 1,
            "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [],
      "locked": true
    },
    {
      "page": 8,
      "type": "appendix",
      "title": "The diagram illustrates the metabolic pathway and the specific block at the Cystathionine beta-synthase step.",
      "function": "frame_problem",
      "rawType": "other",
      "block": null,
      "metadata": {
        "slideType": "other",
        "slideTypeCanon": {
          "name": "Other (fallback)",
          "slug": "other",
          "status": "active",
          "canonId": "019de52d-0af5-71ed-83de-d51ae245fc43",
          "version": 1,
          "description": null
        },
        "function": "frame_problem",
        "functionCanon": {
          "name": "Frame problem",
          "slug": "frame_problem",
          "status": "active",
          "canonId": "019de52d-13db-753e-ad70-e9b2d0dab398",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 48,
        "componentCount": 4,
        "textChars": 591,
        "nDataPoints": 0,
        "notes": "The diagram illustrates the metabolic pathway and the specific block at the Cystathionine beta-synthase step.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 15:31:35.691+00",
          "seconds": 2.633,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/8",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-8",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "x": 905,
            "y": 842
          },
          "kind": "diagram",
          "text": "Metabolic pathway diagram showing conversion of Dietary protein to Methionine, Homocysteine, Cystathionine, and Cysteine, with a block at Cystathionine beta-synthase.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Diagram",
              "slug": "diagram",
              "status": "active",
              "canonId": "019de52c-f9f0-734a-81de-15382ff28c65",
              "version": 1,
              "description": "Schematic or relational diagram."
            },
            "tool": null,
            "subkind": {
              "name": "Process flow",
              "slug": "process",
              "status": "active",
              "canonId": "019de52d-039c-718f-ad3a-efe9c4b3c838",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "process",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 15:31:35.691+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "3208b751-084c-4972-bf31-4b4c5fe4659a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "x": 0.445,
            "y": 0.583
          },
          "kind": "list",
          "text": "Defective CBS enzyme\nPathophysiologic accumulation of Hcy\nInterference with normal cellular processes",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 15:31:35.691+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "54037a6b-d34b-41bf-9e15-538d59342653",
          "parentComponentId": null
        },
        {
          "bbox": {
            "x": 0.962,
            "y": 0.941
          },
          "kind": "source-note",
          "text": "CBS, cystathionine beta-synthase; HCU, homocystinuria; Hcy, homocysteine. 1. Morris AA, et al. J Inherit Metab Dis. 2017;40:49–74; 2. Sacharow SJ, et al. Homocystinuria caused by cystathionine beta-synthase deficiency. 2017. In: Adam MP, et al. GeneReviews® [Internet]. Seattle (WA); 1993–2021.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 15:31:35.691+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d01a5666-3267-4eba-9c2f-05af69f0d2b6",
          "parentComponentId": null
        },
        {
          "bbox": {
            "x": 0.445,
            "y": 0.105
          },
          "kind": "title",
          "text": "Classical HCU: Pathophysiology",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 15:31:35.691+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "094de38a-51be-4872-8109-beec03474d35",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [
        {
          "matchId": "e52101cb-d7bf-4242-99d4-9bd071bd3445",
          "evidence": "The slide describes the sequence of events from enzyme defect to accumulation to cellular interference.",
          "framework": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-05-02 15:31:35.691+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 8,
          "frameworkName": "causal-chain"
        }
      ],
      "arcBeats": [
        {
          "to": 10,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 7,
          "name": "Problem (Identify pain)",
          "beatId": "dfc95667-9e06-43c4-ab5b-f60c317fa5c8",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Problem (Identify pain)",
            "slug": "problem-agitate-solution-problem-identify-pain",
            "status": "active",
            "canonId": "019dd9b8-0e78-74bb-b8f6-54348367a131",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 7-10 provide an overview of Classical HCU, its clinical severity, and current clinical guidelines",
          "position": 0,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Complication",
            "slug": "complication",
            "status": "active",
            "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
            "version": 1,
            "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [],
      "locked": true
    },
    {
      "page": 9,
      "type": "setup",
      "title": "The table contrasts clinical outcomes (Hcy levels, lens dislocation, IQ, thrombosis, mortality) between two patient cohorts.",
      "function": "compare_peers",
      "rawType": "comparison_table",
      "block": null,
      "metadata": {
        "slideType": "comparison_table",
        "slideTypeCanon": {
          "name": "Comparison table",
          "slug": "comparison_table",
          "status": "active",
          "canonId": "019de52d-0a06-73f8-8813-fe022fab1de2",
          "version": 1,
          "description": null
        },
        "function": "compare_peers",
        "functionCanon": {
          "name": "Compare peers",
          "slug": "compare_peers",
          "status": "active",
          "canonId": "019de52d-1453-72ba-a367-9ba3d34c1630",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 57,
        "componentCount": 5,
        "textChars": 376,
        "nDataPoints": 10,
        "notes": "The table contrasts clinical outcomes (Hcy levels, lens dislocation, IQ, thrombosis, mortality) between two patient cohorts.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.125+00",
          "seconds": 2.431,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/9",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-9",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.1,
            "w": 0.95,
            "x": 0.02,
            "y": 0.85
          },
          "kind": "disclaimer",
          "text": "HCU, homocystinuria; Hcy, homocysteine. References 1-5 listed.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.125+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c781fc1e-6c98-4946-bea0-91a13011a1fd",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.7,
            "x": 0.06,
            "y": 0.2
          },
          "kind": "list",
          "text": "62% are biochemically non-responsive; Nonresponsive = more severe phenotype and risk of early mortality",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.125+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1eb62032-f354-49f0-bca2-15ac9828b08b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.37,
            "x": 0.49,
            "y": 0.8
          },
          "kind": "source-note",
          "text": "Adapted from Mudd SH, et al. Am J Hum Genet. 1985;37:1–31",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.125+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ebe90081-7938-4b37-b70e-9e93ab98df39",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.45,
            "w": 0.72,
            "x": 0.14,
            "y": 0.33
          },
          "kind": "table",
          "text": "Comparison of clinical outcomes between Pyridoxine Non-responsive and Responsive HCU patients",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.125+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "604ca578-4f29-4627-9a18-6e1ed72ebb6f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.8,
            "x": 0.02,
            "y": 0.05
          },
          "kind": "title",
          "text": "Classical HCU: Clinical Severity by Pyridoxine Responsiveness",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.125+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d719fb44-e1a8-4f70-bcaf-60d5039a40f2",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 10,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 7,
          "name": "Problem (Identify pain)",
          "beatId": "dfc95667-9e06-43c4-ab5b-f60c317fa5c8",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Problem (Identify pain)",
            "slug": "problem-agitate-solution-problem-identify-pain",
            "status": "active",
            "canonId": "019dd9b8-0e78-74bb-b8f6-54348367a131",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 7-10 provide an overview of Classical HCU, its clinical severity, and current clinical guidelines",
          "position": 0,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Complication",
            "slug": "complication",
            "status": "active",
            "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
            "version": 1,
            "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [],
      "locked": true
    },
    {
      "page": 10,
      "type": "setup",
      "title": "Includes a citation of the specific clinical guidelines paper.",
      "function": "establish_context",
      "rawType": "key_messages",
      "block": null,
      "metadata": {
        "slideType": "key_messages",
        "slideTypeCanon": {
          "name": "Key messages",
          "slug": "key_messages",
          "status": "active",
          "canonId": "019de52d-0712-703f-89f5-bda6688faf3f",
          "version": 1,
          "description": null
        },
        "function": "establish_context",
        "functionCanon": {
          "name": "Establish context",
          "slug": "establish_context",
          "status": "active",
          "canonId": "019de52d-1314-74e6-9074-d213dc0bdcdf",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 53,
        "componentCount": 4,
        "textChars": 565,
        "nDataPoints": 4,
        "notes": "Includes a citation of the specific clinical guidelines paper.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.538+00",
          "seconds": 2.696,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/10",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-10",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.5,
            "w": 0.45,
            "x": 0.52,
            "y": 0.3
          },
          "kind": "image",
          "text": "Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Screenshot",
              "slug": "screenshot",
              "status": "active",
              "canonId": "019de52c-fd87-7509-8391-3d79fb339379",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "screenshot",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.538+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1d369050-8a16-4a88-8b35-294d124c70d2",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.45,
            "x": 0.05,
            "y": 0.25
          },
          "kind": "list",
          "text": "Normal Hcy range: 12–15 µmol/L; No treatment/Non-compliant with treatment Hcy levels: 120-250 µmol/L; Recommended Hcy levels: Pyridoxine non-responsive: <100 µmol/L, Pyridoxine responsive: <50 µmol/L; Goal: Limit methionine intake",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.538+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "efba633f-84fa-4d7d-a05d-772a0850a11f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.9,
            "x": 0.02,
            "y": 0.9
          },
          "kind": "source-note",
          "text": "HCU, homocystinuria; Met, methionine. 1. Morris AA, et al. J Inherit Metab Dis. 2017;40:49–74; 2. Li CQ, et al. Radiology Case. 2018;12:1-8; 3. Woo CWH, et al. Biochimica et Biophysica Acta. 2006;1762:656–665",
          "attrs": {
            "numbered": true
          },
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.538+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "dd215264-4897-4a56-9c92-6af42667713a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.5,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Current Clinical Guidelines",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.538+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "297f7dae-4fd6-45be-80b8-8cdffd1f02cb",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 10,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 7,
          "name": "Problem (Identify pain)",
          "beatId": "dfc95667-9e06-43c4-ab5b-f60c317fa5c8",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Problem (Identify pain)",
            "slug": "problem-agitate-solution-problem-identify-pain",
            "status": "active",
            "canonId": "019dd9b8-0e78-74bb-b8f6-54348367a131",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 7-10 provide an overview of Classical HCU, its clinical severity, and current clinical guidelines",
          "position": 0,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Complication",
            "slug": "complication",
            "status": "active",
            "canonId": "019dd9b8-0275-7709-b2d6-4f77c3fc7579",
            "version": 1,
            "description": "The point in the narrative where the audience should feel discomfort. Required for argumentative arcs."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [],
      "locked": true
    },
    {
      "page": 11,
      "type": "tension",
      "title": "Includes historical context of diagnostic methods (pre-NBS era).",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 53,
        "componentCount": 5,
        "textChars": 437,
        "nDataPoints": 0,
        "notes": "Includes historical context of diagnostic methods (pre-NBS era).",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:51.958+00",
          "seconds": 7.041,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/11",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-11",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.37,
            "x": 0.52,
            "y": 0.298
          },
          "kind": "image",
          "text": "Laboratory technician examining a diagnostic plate",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.958+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "2b7d3c8d-4775-444d-a241-2f2f2e54240c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.25,
            "w": 0.44,
            "x": 0.065,
            "y": 0.35
          },
          "kind": "list",
          "text": "NBS offers opportunity for early diagnosis\n↑ methionine\nGenetic testing, enzymatic activity (confirmatory)",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.958+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "8811ecd2-5ae1-4f02-b08f-fca5222d17b1",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.02,
            "w": 0.315,
            "x": 0.548,
            "y": 0.74
          },
          "kind": "source-note",
          "text": "Historic diagnostic methods (pre-NBS era)",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.958+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "737d8bd5-bb81-4c91-9a3b-d57b44b43d08",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.75,
            "x": 0.026,
            "y": 0.895
          },
          "kind": "subtitle",
          "text": "HCU, homocystinuria; NBS, newborn screening\n1. Morris AA, et al. J Inherit Metab Dis. 2017;40:49–74; 2. Sellos-Moura M, et al. BMC Health Serv Res. 2020;20:183; 3. Morrison T, et al. Orphanet J Rare Dis. 2021;16:124.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Subtitle",
              "slug": "subtitle",
              "status": "active",
              "canonId": "82d821ee-2793-42e7-8f16-c6131385a3ce",
              "version": 1,
              "description": "Header-zone supporting text near the title (= ex body.description with bbox)."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.958+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "eb1fe097-e511-4e0d-8eb8-c9bd786a870c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.096,
            "w": 0.352,
            "x": 0.026,
            "y": 0.046
          },
          "kind": "title",
          "text": "Classical HCU: Diagnosis",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.958+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "0deeea89-267a-4c05-b913-a6b8e6737506",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 14,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 11,
          "name": "Agitate (Make it worse)",
          "beatId": "e2d18a2e-d898-4d6e-9bf1-62eefe35ed84",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Agitate (Make it worse)",
            "slug": "problem-agitate-solution-agitate-make-it-worse",
            "status": "active",
            "canonId": "019dd9b8-0f5a-71dd-bae7-8fadb0d09456",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 11-14 highlight the diagnostic delay, risk of misdiagnosis, and current management limitations",
          "position": 1,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Development",
            "slug": "development",
            "status": "active",
            "canonId": "019dd9b8-0332-7008-b3aa-11b0840a57b1",
            "version": 1,
            "description": "The middle stretch in arcs that have one. Often where length problems creep in."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 14,
          "from": 11,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "946aef3a-76bb-47e2-a4de-02631e3ad727",
          "evidence": "The deck emphasizes the burden of disease and limitations of current management",
          "position": 0,
          "objective": "Highlight the cost of inaction for Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:49.983636+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 12,
      "type": "analysis",
      "title": "The slide uses a table to show symptom overlap (+) and absence (-) between two conditions, accompanied by a visual comparison of patients.",
      "function": "diagnose_problem",
      "rawType": "comparison_table",
      "block": null,
      "metadata": {
        "slideType": "comparison_table",
        "slideTypeCanon": {
          "name": "Comparison table",
          "slug": "comparison_table",
          "status": "active",
          "canonId": "019de52d-0a06-73f8-8813-fe022fab1de2",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 28,
        "componentCount": 3,
        "textChars": 341,
        "nDataPoints": 0,
        "notes": "The slide uses a table to show symptom overlap (+) and absence (-) between two conditions, accompanied by a visual comparison of patients.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.637+00",
          "seconds": 2.641,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/12",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-12",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.89,
            "w": 0.312,
            "x": 0.638,
            "y": 0.195
          },
          "kind": "image",
          "text": "Side-by-side comparison of two patients",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.637+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ec9aa9bc-e78a-4e1a-b3c9-d58ea99a5f83",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.55,
            "w": 0.46,
            "x": 0.07,
            "y": 0.228
          },
          "kind": "table",
          "text": "Symptom/Complication, Classical HCU (1 in 200,000), Marfan Syndrome (1 in 5,000), Ectopia lentis, +, +, Tall stature, +, +, Skeletal abnormalities, +, +, Intellectual disability, +, -, Vascular occlusions, +, -, Mitral valve prolapse, -, +, Aortic root dilation, -, +",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Table",
              "slug": "table",
              "status": "active",
              "canonId": "019de52c-f9c8-7148-8119-eaac9594cd28",
              "version": 1,
              "description": "Tabular data layout."
            },
            "tool": null,
            "subkind": {
              "name": "Data table",
              "slug": "data",
              "status": "active",
              "canonId": "019de52d-02d5-75b8-8abf-88e92bf63569",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "data",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.637+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cf45c3ec-7dc8-4f79-a877-ce773356f314",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.45,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Risk of Misdiagnosis",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.637+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "dbe4b24c-8658-43ca-b098-a8400936c165",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [
        {
          "matchId": "7339e024-c5ac-4dc5-bcf7-d50b400cc8bf",
          "evidence": "The slide uses a table to compare symptoms between two conditions to illustrate diagnostic confusion.",
          "framework": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-05-02 12:27:47.637+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 12,
          "frameworkName": "comparison_frame"
        }
      ],
      "arcBeats": [
        {
          "to": 14,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 11,
          "name": "Agitate (Make it worse)",
          "beatId": "e2d18a2e-d898-4d6e-9bf1-62eefe35ed84",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Agitate (Make it worse)",
            "slug": "problem-agitate-solution-agitate-make-it-worse",
            "status": "active",
            "canonId": "019dd9b8-0f5a-71dd-bae7-8fadb0d09456",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 11-14 highlight the diagnostic delay, risk of misdiagnosis, and current management limitations",
          "position": 1,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Development",
            "slug": "development",
            "status": "active",
            "canonId": "019dd9b8-0332-7008-b3aa-11b0840a57b1",
            "version": 1,
            "description": "The middle stretch in arcs that have one. Often where length problems creep in."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 14,
          "from": 11,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "946aef3a-76bb-47e2-a4de-02631e3ad727",
          "evidence": "The deck emphasizes the burden of disease and limitations of current management",
          "position": 0,
          "objective": "Highlight the cost of inaction for Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:49.983636+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 13,
      "type": "tension",
      "title": "The slide highlights the clinical consequences of missing HCU in newborn screening (NBS).",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 62,
        "componentCount": 5,
        "textChars": 536,
        "nDataPoints": 4,
        "notes": "The slide highlights the clinical consequences of missing HCU in newborn screening (NBS).",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.998+00",
          "seconds": 2.967,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/13",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-13",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.03,
            "w": 0.25,
            "x": 0.02,
            "y": 0.95
          },
          "kind": "disclaimer",
          "text": "HCU, homocystinuria; NBS, newborn screening.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Disclaimer",
              "slug": "disclaimer",
              "status": "active",
              "canonId": "91173477-d91f-4024-bbaf-d4f93e3f82dc",
              "version": 1,
              "description": "Legal/cautionary text that occupies most of the body of its slide."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.998+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "d750a8dd-531a-414d-8532-fcb6e1c483a6",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.5,
            "w": 0.4,
            "x": 0.53,
            "y": 0.28
          },
          "kind": "list",
          "text": "Complications: Pulmonary embolus (age 23 y). HCU Diagnosis: Suggested during hospitalization, Plasma Hcy: 230 µmol/L. HCU Management & Outcome: Dietary restriction + betaine, Hcy: 120–170 µmol/L, At risk of new pulmonary embolism or stroke",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.998+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "78b598eb-ae93-424c-b4a6-f7ecf6d8fdde",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.4,
            "w": 0.4,
            "x": 0.05,
            "y": 0.3
          },
          "kind": "list",
          "text": "Clinical features: Lens dislocation with myopia (age 8 y), Tall and thin, long arms and legs, Developmental delay, intellectual disability. Initial diagnosis: Marfan syndrome",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.998+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cc71b40d-8a8a-4b16-81ee-b46118f45c5b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.4,
            "x": 0.06,
            "y": 0.2
          },
          "kind": "paragraph",
          "text": "Case 1: male patient not ascertained through NBS",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.998+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "5947d42d-db5f-491f-ac69-2d61e1251238",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.45,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Diagnostic Delay",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.998+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "008c5fce-d3a1-4f6e-9717-847f2e6ed53c",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 14,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 11,
          "name": "Agitate (Make it worse)",
          "beatId": "e2d18a2e-d898-4d6e-9bf1-62eefe35ed84",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Agitate (Make it worse)",
            "slug": "problem-agitate-solution-agitate-make-it-worse",
            "status": "active",
            "canonId": "019dd9b8-0f5a-71dd-bae7-8fadb0d09456",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 11-14 highlight the diagnostic delay, risk of misdiagnosis, and current management limitations",
          "position": 1,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Development",
            "slug": "development",
            "status": "active",
            "canonId": "019dd9b8-0332-7008-b3aa-11b0840a57b1",
            "version": 1,
            "description": "The middle stretch in arcs that have one. Often where length problems creep in."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 14,
          "from": 11,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "946aef3a-76bb-47e2-a4de-02631e3ad727",
          "evidence": "The deck emphasizes the burden of disease and limitations of current management",
          "position": 0,
          "objective": "Highlight the cost of inaction for Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:49.983636+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 14,
      "type": "appendix",
      "title": "The slide displays various medical nutrition products used for HCU management.",
      "function": "establish_context",
      "rawType": "other",
      "block": null,
      "metadata": {
        "slideType": "other",
        "slideTypeCanon": {
          "name": "Other (fallback)",
          "slug": "other",
          "status": "active",
          "canonId": "019de52d-0af5-71ed-83de-d51ae245fc43",
          "version": 1,
          "description": null
        },
        "function": "establish_context",
        "functionCanon": {
          "name": "Establish context",
          "slug": "establish_context",
          "status": "active",
          "canonId": "019de52d-1314-74e6-9074-d213dc0bdcdf",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 38,
        "componentCount": 4,
        "textChars": 348,
        "nDataPoints": 0,
        "notes": "The slide displays various medical nutrition products used for HCU management.",
        "elementsJson": null,
        "confidence": 0.9,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.609+00",
          "seconds": 2.528,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/14",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-14",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.88,
            "w": 0.36,
            "x": 0.58,
            "y": 0.215
          },
          "kind": "image",
          "text": "Product images of HCU medical nutrition formulas",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Illustration",
              "slug": "illustration",
              "status": "active",
              "canonId": "019de52c-fe76-7772-a5ac-c0b7294d7615",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "illustration",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.609+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "73faf1e8-8a75-4584-8116-30a09076244f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.4,
            "w": 0.45,
            "x": 0.07,
            "y": 0.33
          },
          "kind": "list",
          "text": "Mainstay of care: severe protein restriction plus formula and supplementation with betaine\nMonitoring: eyes, development, cognition, bone density\nGoal: maintain normal nutrition and prevent serious complications",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.609+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c34d9274-72c2-40e5-8286-8075cada3f70",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.3,
            "x": 0.02,
            "y": 0.92
          },
          "kind": "source-note",
          "text": "1. Morris AA, et al. J Inherit Metab Dis. 2017;40:49–74.",
          "attrs": {
            "numbered": true
          },
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.609+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f7c975af-cee8-4231-aaed-4d95c963fd85",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.5,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Current Management",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.609+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "89390962-b19b-4b9a-a9b4-5df56570cef3",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 14,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 11,
          "name": "Agitate (Make it worse)",
          "beatId": "e2d18a2e-d898-4d6e-9bf1-62eefe35ed84",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Agitate (Make it worse)",
            "slug": "problem-agitate-solution-agitate-make-it-worse",
            "status": "active",
            "canonId": "019dd9b8-0f5a-71dd-bae7-8fadb0d09456",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 11-14 highlight the diagnostic delay, risk of misdiagnosis, and current management limitations",
          "position": 1,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Development",
            "slug": "development",
            "status": "active",
            "canonId": "019dd9b8-0332-7008-b3aa-11b0840a57b1",
            "version": 1,
            "description": "The middle stretch in arcs that have one. Often where length problems creep in."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 14,
          "from": 11,
          "loop": {
            "name": "27_cost_of_inaction",
            "slug": "27-cost-of-inaction",
            "status": "active",
            "bestFor": "Urgent budget requests, compliance, risk mitigation",
            "canonId": "019dd956-70d1-7395-a15b-857ba858b394",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
            "description": "Quantify what happens if the audience does nothing",
            "familyLabel": null
          },
          "matchId": "946aef3a-76bb-47e2-a4de-02631e3ad727",
          "evidence": "The deck emphasizes the burden of disease and limitations of current management",
          "position": 0,
          "objective": "Highlight the cost of inaction for Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:49.983636+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 15,
      "type": "tension",
      "title": "Includes a clinical photograph of two patients, likely illustrating physical manifestations or growth issues associated with the condition.",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 44,
        "componentCount": 4,
        "textChars": 454,
        "nDataPoints": 0,
        "notes": "Includes a clinical photograph of two patients, likely illustrating physical manifestations or growth issues associated with the condition.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.533+00",
          "seconds": 2.396,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/15",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-15",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.663,
            "w": 0.258,
            "x": 0.695,
            "y": 0.233
          },
          "kind": "image",
          "text": "Clinical photograph of two patients against a height chart",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.533+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6ddaa7ea-a6ee-456b-b07d-6dd6e57aa6b0",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.5,
            "x": 0.06,
            "y": 0.22
          },
          "kind": "list",
          "text": "Life-long protein dietary restriction difficult to maintain; Betaine unpalatable with gastrointestinal side effects; Inadequate control associated with greater risk of: Pulmonary embolus, Stroke, Increasing osteoporosis with complications, Psychological/psychiatric problems",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.533+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "24edf2d1-4c4b-4094-a102-fa339511dffd",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.3,
            "x": 0.02,
            "y": 0.9
          },
          "kind": "source-note",
          "text": "HCU, homocystinuria. Morris AA, et al. J Inherit Metab Dis. 2017;40:49–74.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.533+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e4834def-acc6-472c-81cf-72762fb258ba",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.7,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Limitations of Current Management",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.533+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b72cf721-48de-4613-bd1c-f825b4b17e93",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 16,
      "type": "appendix",
      "title": "Case study format used to illustrate the consequences of poor disease management.",
      "function": "illustrate_case",
      "rawType": "other",
      "block": null,
      "metadata": {
        "slideType": "other",
        "slideTypeCanon": {
          "name": "Other (fallback)",
          "slug": "other",
          "status": "active",
          "canonId": "019de52d-0af5-71ed-83de-d51ae245fc43",
          "version": 1,
          "description": null
        },
        "function": "illustrate_case",
        "functionCanon": {
          "name": "Illustrate case",
          "slug": "illustrate_case",
          "status": "active",
          "canonId": "019de52d-13b4-772c-bb73-1873612a7463",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 57,
        "componentCount": 5,
        "textChars": 400,
        "nDataPoints": 6,
        "notes": "Case study format used to illustrate the consequences of poor disease management.",
        "elementsJson": null,
        "confidence": 0.95,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:48.144+00",
          "seconds": 2.723,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/16",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-16",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.45,
            "w": 0.42,
            "x": 0.06,
            "y": 0.034
          },
          "kind": "list",
          "text": "Treatment: Diet (from age 8 days) and betaine. Hcy: Early levels 35-70, increased over time to 120-180.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.144+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "96a96ee7-be9e-405b-aef7-83322cb844ae",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.45,
            "w": 0.42,
            "x": 0.53,
            "y": 0.034
          },
          "kind": "list",
          "text": "Complications: Myopia, developmental delay, psychological problems, osteoporosis, stroke. Long-term: reliant on caregiver.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.144+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ebadf27e-12dd-478d-83e0-cbb6ab8d57ee",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.04,
            "w": 0.65,
            "x": 0.06,
            "y": 0.19
          },
          "kind": "paragraph",
          "text": "Case 2: female patient ascertained through NBS but with poor Hcy control",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.144+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4c5dd032-e236-4c20-8452-8d4701ca74a4",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.32,
            "x": 0.02,
            "y": 0.95
          },
          "kind": "source-note",
          "text": "HCU, homocystinuria; Hcy, homocysteine; NBS, newborn screening.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.144+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cdbd45b6-f475-46fa-933e-9d5d489632ea",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.58,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Limitations of Management",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.144+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "67bd6895-442e-4b2b-aca4-553664f591e8",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 17,
      "type": "tension",
      "title": "The slide uses a list-based approach to describe the disease burden, paired with a visual column of key clinical manifestations.",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 69,
        "componentCount": 7,
        "textChars": 467,
        "nDataPoints": 0,
        "notes": "The slide uses a list-based approach to describe the disease burden, paired with a visual column of key clinical manifestations.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:54.402+00",
          "seconds": 8.917,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/17",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-17",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.075,
            "w": 0.255,
            "x": 0.738,
            "y": 0.388
          },
          "kind": "callout",
          "text": "Cognitive decline/dementia",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "04bea8ee-5809-4947-a09e-8f91f157a499",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.075,
            "w": 0.255,
            "x": 0.738,
            "y": 0.688
          },
          "kind": "callout",
          "text": "Depression",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c5e76aeb-15a6-4385-8cf3-b615ac89a673",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.075,
            "w": 0.255,
            "x": 0.738,
            "y": 0.238
          },
          "kind": "callout",
          "text": "Vascular disease",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "dd68f2a9-e6e3-4bd2-bf48-a8a5d09c5a6e",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.075,
            "w": 0.255,
            "x": 0.738,
            "y": 0.538
          },
          "kind": "callout",
          "text": "Osteoporotic fracture",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e60dff6e-80ea-49f0-bc28-1f59632b3774",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.5,
            "w": 0.6,
            "x": 0.05,
            "y": 0.25
          },
          "kind": "list",
          "text": "Long-term consequences increase health burden and decrease QOL1-5\nConsequences and outcomes worse with more severe Hcy elevation6\nHigh medication burden and increased hospitalizations6\nVery restricted diet extremely burdensome for patients and caregivers7",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "bb7c0d8d-2b04-4d78-9379-c2181a49131f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.9,
            "x": 0.02,
            "y": 0.87
          },
          "kind": "source-note",
          "text": "HCU, homocystinuria; Hcy, homocysteine; QOL, quality of life. 1-7 references listed.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1f36c3eb-3272-4e50-b69f-54eb718f6341",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.8,
            "x": 0.02,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: Burden of Disease and Current Management",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:54.402+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "678a94a7-110e-48e0-8306-c8de20a3889b",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 18,
      "type": "tension",
      "title": "The slide uses a simple problem-solution structure, identifying the clinical gap and the resulting need.",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 39,
        "componentCount": 4,
        "textChars": 362,
        "nDataPoints": 0,
        "notes": "The slide uses a simple problem-solution structure, identifying the clinical gap and the resulting need.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:48.134+00",
          "seconds": 2.411,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/18",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-18",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.15,
            "w": 0.8,
            "x": 0.1,
            "y": 0.518
          },
          "kind": "callout",
          "text": "New and effective therapies addressing clinical outcomes of patients with classical HCU are needed",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.134+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c10e9665-d224-41ec-a986-9215bb91e70d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.93,
            "x": 0.07,
            "y": 0.29
          },
          "kind": "list",
          "text": "Suboptimal control of Hcy is associated with more severe disease and poorer outcomes\nPatients with classical HCU experience significant disease burden and risk of permanent morbidity",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.134+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "1a99a0de-cc88-4794-80a1-6160f278b7cd",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.2,
            "x": 0.025,
            "y": 0.92
          },
          "kind": "source-note",
          "text": "HCU, homocystinuria; Hcy, homocysteine..",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.134+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f96b575d-5166-4cd7-ae0d-20728143b061",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.105,
            "w": 0.605,
            "x": 0.025,
            "y": 0.045
          },
          "kind": "title",
          "text": "Therapeutic Needs: Clinical Considerations",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.134+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "198ff9bd-a727-477c-9e57-715a2871896f",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 19,
      "type": "setup",
      "function": "closing_ask",
      "rawType": "closing_ask",
      "block": null,
      "metadata": {
        "slideType": "closing_ask",
        "slideTypeCanon": {
          "name": "Closing ask",
          "slug": "closing_ask",
          "status": "active",
          "canonId": "019de52d-0aa4-750f-8aa1-8d622dd99f5c",
          "version": 1,
          "description": null
        },
        "function": "closing_ask",
        "functionCanon": {
          "name": "Closing ask (contrarian)",
          "slug": "closing_ask",
          "status": "active",
          "canonId": "019de52d-18d2-7137-8c99-0a14eb350f0f",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 1,
        "componentCount": 1,
        "textChars": 9,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:47.239+00",
          "seconds": 1.465,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/19",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-19",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.12,
            "w": 0.22,
            "x": 0.39,
            "y": 0.44
          },
          "kind": "title",
          "text": "Thank You",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:47.239+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "5aa37c1e-309f-4036-83ca-1f1c710ac667",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 20,
      "type": "setup",
      "function": "front_matter",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 8,
        "componentCount": 2,
        "textChars": 88,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:48.067+00",
          "seconds": 2.248,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/20",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-20",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 1,
            "w": 1,
            "x": 0,
            "y": 0
          },
          "kind": "image",
          "text": null,
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.067+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "47caac7b-252a-460f-aa40-83172f329d90",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.15,
            "w": 0.8,
            "x": 0.08,
            "y": 0.75
          },
          "kind": "title",
          "text": "Pegtarviliase (formerly AGLE-177) – Potential Best-in-Class Treatment for Homocystinuria",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:48.067+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "49389f88-4965-4bb6-bba1-fcae7b958290",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 24,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 20,
          "name": "Solution (Provide relief)",
          "beatId": "5fa22bc5-87f2-4946-9705-fa014d063ae3",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Solution (Provide relief)",
            "slug": "problem-agitate-solution-solution-provide-relief",
            "status": "active",
            "canonId": "019dd9b8-0fee-73e9-9ae5-799c7f3895cd",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach",
          "position": 2,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Resolution",
            "slug": "resolution",
            "status": "active",
            "canonId": "019dd9b8-045d-703b-8dd7-e92aba3ba91b",
            "version": 1,
            "description": "How the deck ends. Required in 19/20 arcs. The exception (Sparkline) ends with new bliss which is functionally a resolution."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 24,
          "from": 20,
          "loop": {
            "name": "53_jobs_to_be_done",
            "slug": "53-jobs-to-be-done",
            "status": "active",
            "bestFor": "Product innovation, market entry, competitive positioning",
            "canonId": "019dd956-7b6c-7594-b5b3-eecbe0ab48e8",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
            "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying",
            "familyLabel": null
          },
          "matchId": "8d7561ed-879a-4cee-9208-d194f7670c57",
          "evidence": "The deck presents Pegtarviliase as a potential best-in-class treatment",
          "position": 1,
          "objective": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:50.017864+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 21,
      "type": "tension",
      "title": "The slide uses a pie chart to show patient segmentation by B6 responsiveness and a timeline/number-line to show age of diagnosis, followed by key metrics on com",
      "function": "diagnose_problem",
      "rawType": "problem_statement",
      "block": null,
      "metadata": {
        "slideType": "problem_statement",
        "slideTypeCanon": {
          "name": "Problem statement",
          "slug": "problem_statement",
          "status": "active",
          "canonId": "019de52d-0879-768d-bba8-8da8a5a121d4",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "overcrowded",
        "densityScore": 80,
        "componentCount": 7,
        "textChars": 643,
        "nDataPoints": 8,
        "notes": "The slide uses a pie chart to show patient segmentation by B6 responsiveness and a timeline/number-line to show age of diagnosis, followed by key metrics on complication rates.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:49.214+00",
          "seconds": 3.296,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/21",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-21",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.15,
            "w": 0.4,
            "x": 0.55,
            "y": 0.18
          },
          "kind": "chart",
          "text": "Average Age of Diagnosis",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Line chart",
              "slug": "line",
              "status": "active",
              "canonId": "019de52c-ff62-778f-8f6c-a952ceae8677",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "line",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "00d68979-6892-4434-b325-29d980757d5b",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.4,
            "w": 0.4,
            "x": 0.08,
            "y": 0.22
          },
          "kind": "chart",
          "text": "Classical HCU by B6 Responsiveness",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Chart",
              "slug": "chart",
              "status": "active",
              "canonId": "019de52c-f9a0-76ef-adc6-0b859109d1f8",
              "version": 1,
              "description": "Quantitative chart."
            },
            "tool": null,
            "subkind": {
              "name": "Pie chart",
              "slug": "pie",
              "status": "active",
              "canonId": "019de52c-ffdb-71bb-a800-5c5ab9f1c373",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "pie",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "9245aa3f-ba67-4f18-ac43-d8fdd5fea6ad",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.45,
            "x": 0.05,
            "y": 0.68
          },
          "kind": "list",
          "text": "Over 80% of patients are unable to achieve tHcy levels <50 µM with B6 alone. This translates into an estimated ~25,000 treatment candidates in global addressable markets, approximately 8,500 of whom are in the U.S., EU4, and UK",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "57e15823-64d4-44b9-826d-28479df39122",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.4,
            "x": 0.55,
            "y": 0.78
          },
          "kind": "metric",
          "text": "29% Non-Responders and Partial Responders have experienced a thromboembolic event",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Metric",
              "slug": "metric",
              "status": "active",
              "canonId": "019de52c-f923-73bf-8081-d0b1a8c5264d",
              "version": 1,
              "description": "Big-number or KPI value."
            },
            "tool": null,
            "subkind": {
              "name": "Big number",
              "slug": "big-number",
              "status": "active",
              "canonId": "019de52c-fc70-70c8-b965-0584548a9204",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "big-number",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "01090f17-1cc6-4fe7-9b23-574078e1ac76",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.4,
            "x": 0.55,
            "y": 0.7
          },
          "kind": "metric",
          "text": "79% Non-Responders and Partial Responders have experienced a lens dislocation",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Metric",
              "slug": "metric",
              "status": "active",
              "canonId": "019de52c-f923-73bf-8081-d0b1a8c5264d",
              "version": 1,
              "description": "Big-number or KPI value."
            },
            "tool": null,
            "subkind": {
              "name": "Big number",
              "slug": "big-number",
              "status": "active",
              "canonId": "019de52c-fc70-70c8-b965-0584548a9204",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "big-number",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4f8bc822-17d3-49c4-b42f-deb25de49610",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.7,
            "x": 0.06,
            "y": 0.91
          },
          "kind": "source-note",
          "text": "Data on file. Adapted from Sellos-Moura et al 2020. Kozich, Sokolova, Morris, et al. 2021. Mudd, Skovby et al. 1985.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b4e158f2-146d-4db8-9fc4-f0285fb5cd0a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.88,
            "x": 0.06,
            "y": 0.04
          },
          "kind": "title",
          "text": "Classical HCU: A Sizeable Patient Population at Serious Risk of Severe Complications",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.214+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "bcd84d46-dff5-4f41-aee7-c36a795da023",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "2x2 matrix",
            "slug": "matrix-2x2",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd9e1-50ab-72d1-8afb-3ab0a38e32a8",
            "version": 1,
            "bodyDocId": null,
            "description": "BCG matrix, importance/urgency, any axes-and-quadrants frame.",
            "familyLabel": null,
            "categoryName": null,
            "categorySlug": null
          },
          "agent": null,
          "layer": "slide",
          "agents": null,
          "matchId": "f58e1f6e-d33f-4aa8-a797-51de0d271884",
          "evidence": "This slide includes a pie chart showing Classical HCU by B6 Responsiveness, which can be interpreted as a 2x2 matrix.",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 03:57:40.93429+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 21,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": "common",
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 24,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 20,
          "name": "Solution (Provide relief)",
          "beatId": "5fa22bc5-87f2-4946-9705-fa014d063ae3",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Solution (Provide relief)",
            "slug": "problem-agitate-solution-solution-provide-relief",
            "status": "active",
            "canonId": "019dd9b8-0fee-73e9-9ae5-799c7f3895cd",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach",
          "position": 2,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Resolution",
            "slug": "resolution",
            "status": "active",
            "canonId": "019dd9b8-045d-703b-8dd7-e92aba3ba91b",
            "version": 1,
            "description": "How the deck ends. Required in 19/20 arcs. The exception (Sparkline) ends with new bliss which is functionally a resolution."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 24,
          "from": 20,
          "loop": {
            "name": "53_jobs_to_be_done",
            "slug": "53-jobs-to-be-done",
            "status": "active",
            "bestFor": "Product innovation, market entry, competitive positioning",
            "canonId": "019dd956-7b6c-7594-b5b3-eecbe0ab48e8",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
            "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying",
            "familyLabel": null
          },
          "matchId": "8d7561ed-879a-4cee-9208-d194f7670c57",
          "evidence": "The deck presents Pegtarviliase as a potential best-in-class treatment",
          "position": 1,
          "objective": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:50.017864+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 22,
      "type": "analysis",
      "function": "diagnose_problem",
      "rawType": "pain_points",
      "block": null,
      "metadata": {
        "slideType": "pain_points",
        "slideTypeCanon": {
          "name": "Pain points",
          "slug": "pain_points",
          "status": "active",
          "canonId": "019de52d-08a0-761d-a14f-1dbc5e447381",
          "version": 1,
          "description": null
        },
        "function": "diagnose_problem",
        "functionCanon": {
          "name": "Diagnose problem",
          "slug": "diagnose_problem",
          "status": "active",
          "canonId": "019de52d-176d-761f-b608-cf52262d2ab2",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 70,
        "componentCount": 6,
        "textChars": 744,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:52.93+00",
          "seconds": 6.913,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/22",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-22",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.1,
            "w": 0.7,
            "x": 0.15,
            "y": 0.8
          },
          "kind": "callout",
          "text": "With persistently high tHcy levels, patients remain at risk for serious and life-threatening complications",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:52.93+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b837da87-9dab-4b3d-b706-8a1c6e779b93",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.37,
            "w": 0.253,
            "x": 0.535,
            "y": 0.218
          },
          "kind": "image",
          "text": "Hand holding a large number of pills",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:52.93+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "990331b2-a432-4595-9655-5476bb310fa7",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.45,
            "x": 0.06,
            "y": 0.22
          },
          "kind": "list",
          "text": "Compliance with severe dietary restrictions and amino acid supplementation is extremely challenging and represents a lifelong burden. Vitamin B6 is largely ineffective for the majority of patients. Betaine can be associated with both safety and tolerability issues.",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:52.93+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "84883ae0-3f4d-4000-9c82-b64873ff98a0",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.45,
            "x": 0.06,
            "y": 0.635
          },
          "kind": "quote",
          "text": "For patients with Classical Homocystinuria, [the biggest challenge] would be compliance with diet. - U.S. Key Opinion Leader",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Quote",
              "slug": "quote",
              "status": "active",
              "canonId": "019de52c-f8fb-751e-8bc6-d58e2d59562a",
              "version": 1,
              "description": "Pull quote or testimonial."
            },
            "tool": null,
            "subkind": {
              "name": "Testimonial",
              "slug": "testimonial",
              "status": "active",
              "canonId": "019de52c-fc21-71b6-9ac3-8266a64945e8",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "testimonial",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:52.93+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "dc1f132a-ed35-424e-b84f-2f24b6cb54ad",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.45,
            "x": 0.535,
            "y": 0.635
          },
          "kind": "quote",
          "text": "To get the family to cope with a very difficult life, and to have them compliant for life ... is a very big challenge. - EU Key Opinion Leader",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Quote",
              "slug": "quote",
              "status": "active",
              "canonId": "019de52c-f8fb-751e-8bc6-d58e2d59562a",
              "version": 1,
              "description": "Pull quote or testimonial."
            },
            "tool": null,
            "subkind": {
              "name": "Testimonial",
              "slug": "testimonial",
              "status": "active",
              "canonId": "019de52c-fc21-71b6-9ac3-8266a64945e8",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "testimonial",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:52.93+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "fc2de65f-66fb-4ac4-8c20-02005ece260d",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.12,
            "w": 0.75,
            "x": 0.06,
            "y": 0.05
          },
          "kind": "title",
          "text": "Patients with Classical HCU Live With Both Disease and Treatment Burden",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:52.93+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "6769ebf7-2940-4548-a47c-e3d19c222776",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 24,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 20,
          "name": "Solution (Provide relief)",
          "beatId": "5fa22bc5-87f2-4946-9705-fa014d063ae3",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Solution (Provide relief)",
            "slug": "problem-agitate-solution-solution-provide-relief",
            "status": "active",
            "canonId": "019dd9b8-0fee-73e9-9ae5-799c7f3895cd",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach",
          "position": 2,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Resolution",
            "slug": "resolution",
            "status": "active",
            "canonId": "019dd9b8-045d-703b-8dd7-e92aba3ba91b",
            "version": 1,
            "description": "How the deck ends. Required in 19/20 arcs. The exception (Sparkline) ends with new bliss which is functionally a resolution."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 24,
          "from": 20,
          "loop": {
            "name": "53_jobs_to_be_done",
            "slug": "53-jobs-to-be-done",
            "status": "active",
            "bestFor": "Product innovation, market entry, competitive positioning",
            "canonId": "019dd956-7b6c-7594-b5b3-eecbe0ab48e8",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
            "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying",
            "familyLabel": null
          },
          "matchId": "8d7561ed-879a-4cee-9208-d194f7670c57",
          "evidence": "The deck presents Pegtarviliase as a potential best-in-class treatment",
          "position": 1,
          "objective": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:50.017864+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 23,
      "type": "setup",
      "title": "The slide uses a process flow diagram to show the metabolic block (CBS deficiency) and the therapeutic intervention point.",
      "function": "present_solution",
      "rawType": "propose_solution",
      "block": null,
      "metadata": {
        "slideType": "propose_solution",
        "slideTypeCanon": {
          "name": "Propose solution (contrarian)",
          "slug": "propose_solution",
          "status": "active",
          "canonId": "019de52d-1274-703c-81c6-5550f451697b",
          "version": 1,
          "description": null
        },
        "function": "present_solution",
        "functionCanon": {
          "name": "Present solution",
          "slug": "present_solution",
          "status": "active",
          "canonId": "019de52d-15b8-71da-bd23-2b767850cbce",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 41,
        "componentCount": 4,
        "textChars": 302,
        "nDataPoints": 3,
        "notes": "The slide uses a process flow diagram to show the metabolic block (CBS deficiency) and the therapeutic intervention point.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:49.181+00",
          "seconds": 3.05,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/23",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-23",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.12,
            "w": 0.8,
            "x": 0.1,
            "y": 0.78
          },
          "kind": "callout",
          "text": "Pegtarviliase: Engineered human enzyme metabolizes multiple forms of free homocysteine to naturally occurring metabolites",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.181+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "4b838f11-ab14-4f96-a6e3-8a6a242d84ed",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.62,
            "w": 0.88,
            "x": 0.06,
            "y": 0.18
          },
          "kind": "diagram",
          "text": "Intracellular metabolic pathway showing CBS block and Plasma transport equilibrium",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Diagram",
              "slug": "diagram",
              "status": "active",
              "canonId": "019de52c-f9f0-734a-81de-15382ff28c65",
              "version": 1,
              "description": "Schematic or relational diagram."
            },
            "tool": null,
            "subkind": {
              "name": "Process flow",
              "slug": "process",
              "status": "active",
              "canonId": "019de52d-039c-718f-ad3a-efe9c4b3c838",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "process",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.181+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "61bfbd01-5f04-4edf-a7e2-a60f17ce7d6a",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.2,
            "x": 0.06,
            "y": 0.91
          },
          "kind": "source-note",
          "text": "1. Morris et al J Inherit Metab Dis 2017",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.181+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "cc8048c2-48df-43f9-846b-b8926ffebea9",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.88,
            "x": 0.06,
            "y": 0.04
          },
          "kind": "title",
          "text": "Homocysteine Metabolism & Pegtarviliase Mechanism of Action",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.181+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b42ca546-8496-4fa7-aad9-bd47ee5d717a",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [
        {
          "matchId": "b8bef4a3-479f-445e-a4e8-f3c258165496",
          "evidence": "The slide maps the biochemical pathway from dietary protein to homocysteine accumulation and the subsequent therapeutic intervention.",
          "framework": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-05-02 12:27:49.181+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 23,
          "frameworkName": "causal-chain"
        }
      ],
      "arcBeats": [
        {
          "to": 24,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 20,
          "name": "Solution (Provide relief)",
          "beatId": "5fa22bc5-87f2-4946-9705-fa014d063ae3",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Solution (Provide relief)",
            "slug": "problem-agitate-solution-solution-provide-relief",
            "status": "active",
            "canonId": "019dd9b8-0fee-73e9-9ae5-799c7f3895cd",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach",
          "position": 2,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Resolution",
            "slug": "resolution",
            "status": "active",
            "canonId": "019dd9b8-045d-703b-8dd7-e92aba3ba91b",
            "version": 1,
            "description": "How the deck ends. Required in 19/20 arcs. The exception (Sparkline) ends with new bliss which is functionally a resolution."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 24,
          "from": 20,
          "loop": {
            "name": "53_jobs_to_be_done",
            "slug": "53-jobs-to-be-done",
            "status": "active",
            "bestFor": "Product innovation, market entry, competitive positioning",
            "canonId": "019dd956-7b6c-7594-b5b3-eecbe0ab48e8",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
            "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying",
            "familyLabel": null
          },
          "matchId": "8d7561ed-879a-4cee-9208-d194f7670c57",
          "evidence": "The deck presents Pegtarviliase as a potential best-in-class treatment",
          "position": 1,
          "objective": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:50.017864+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 24,
      "type": "setup",
      "title": "The slide uses a biological process diagram to contrast normal intracellular metabolism with the therapeutic effect of the drug in the plasma.",
      "function": "present_solution",
      "rawType": "propose_solution",
      "block": null,
      "metadata": {
        "slideType": "propose_solution",
        "slideTypeCanon": {
          "name": "Propose solution (contrarian)",
          "slug": "propose_solution",
          "status": "active",
          "canonId": "019de52d-1274-703c-81c6-5550f451697b",
          "version": 1,
          "description": null
        },
        "function": "present_solution",
        "functionCanon": {
          "name": "Present solution",
          "slug": "present_solution",
          "status": "active",
          "canonId": "019de52d-15b8-71da-bd23-2b767850cbce",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 35,
        "componentCount": 4,
        "textChars": 287,
        "nDataPoints": 0,
        "notes": "The slide uses a biological process diagram to contrast normal intracellular metabolism with the therapeutic effect of the drug in the plasma.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:49.142+00",
          "seconds": 2.933,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/24",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-24",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.6,
            "w": 0.45,
            "x": 0.05,
            "y": 0.22
          },
          "kind": "image",
          "text": "Depiction of Normal and Therapeutic Metabolism",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Illustration",
              "slug": "illustration",
              "status": "active",
              "canonId": "019de52c-fe76-7772-a5ac-c0b7294d7615",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "illustration",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.142+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "f44ea206-4833-4f0a-99c1-2ee408a501d2",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.6,
            "w": 0.45,
            "x": 0.52,
            "y": 0.22
          },
          "kind": "list",
          "text": "Summary of Pegtarviliase Therapeutic Rationale",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.142+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "e727b464-bed6-415a-9793-e94029f0eb9f",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.6,
            "x": 0.05,
            "y": 0.92
          },
          "kind": "source-note",
          "text": "Mudd, Skovby et al. 1985, Al-Dewik, Ali et al. 2019; Mudd, Skovby et al. 1985, Wilcken and Wilcken 1997, Yap and Naughten 1998",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.142+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b76eb668-c755-43c9-8894-cea205758e30",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.06,
            "w": 0.9,
            "x": 0.05,
            "y": 0.04
          },
          "kind": "title",
          "text": "Pegtarviliase: An Innovative Enzyme Approach to Lowering Homocysteine",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.142+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b5f4ac5d-d248-40ea-b088-2c4e7645c37b",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Problem Statement Canvas",
            "slug": "problem-statement-canvas",
            "status": "active",
            "bestFor": null,
            "canonId": "019dd956-839d-744b-ad11-9bf3e3642a18",
            "version": 1,
            "bodyDocId": null,
            "description": "Structured definition of the problem: What? Who? Where? When? Scale?",
            "familyLabel": null,
            "categoryName": "Block",
            "categorySlug": "block"
          },
          "agent": "Architect",
          "layer": "slide",
          "agents": [
            "Architect"
          ],
          "matchId": "e0ba1fc4-6a30-49b7-a68b-846a58bfde41",
          "evidence": "Depiction of Normal and Therapeutic Metabolism",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.7,
          "extraction": {
            "at": "2026-07-17 00:11:34.869901+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 24,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [
        {
          "to": 24,
          "arc": {
            "name": "Problem-Agitate-Solution",
            "slug": "problem-agitate-solution",
            "status": "active",
            "bestFor": "Sales pitches, urgency-driven, competitive displacement",
            "canonId": "019dd956-5ec6-70f9-9fd8-fdbaaff39acf",
            "version": 1,
            "bodyDocId": "019df22a-2356-73eb-8061-d8c81dc0aa49",
            "structure": "Problem (Identify pain) -> Agitate (Make it worse) -> Solution (Provide relief)",
            "description": null,
            "familyLabel": null
          },
          "from": 20,
          "name": "Solution (Provide relief)",
          "beatId": "5fa22bc5-87f2-4946-9705-fa014d063ae3",
          "matchId": "f150d8c7-8fe7-4ded-a7a4-b9e4faf13e69",
          "beatType": {
            "name": "Solution (Provide relief)",
            "slug": "problem-agitate-solution-solution-provide-relief",
            "status": "active",
            "canonId": "019dd9b8-0fee-73e9-9ae5-799c7f3895cd",
            "version": 1,
            "description": null
          },
          "evidence": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach",
          "position": 2,
          "isPrimaryArc": true,
          "parentBeatType": {
            "name": "Resolution",
            "slug": "resolution",
            "status": "active",
            "canonId": "019dd9b8-045d-703b-8dd7-e92aba3ba91b",
            "version": 1,
            "description": "How the deck ends. Required in 19/20 arcs. The exception (Sparkline) ends with new bliss which is functionally a resolution."
          },
          "alignedBlockIds": null,
          "matchConfidence": 0.8
        }
      ],
      "loops": [
        {
          "to": 24,
          "from": 20,
          "loop": {
            "name": "53_jobs_to_be_done",
            "slug": "53-jobs-to-be-done",
            "status": "active",
            "bestFor": "Product innovation, market entry, competitive positioning",
            "canonId": "019dd956-7b6c-7594-b5b3-eecbe0ab48e8",
            "version": 1,
            "bodyDocId": "019df22a-2420-77be-bc41-ded96d08cb21",
            "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
            "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying",
            "familyLabel": null
          },
          "matchId": "8d7561ed-879a-4cee-9208-d194f7670c57",
          "evidence": "The deck presents Pegtarviliase as a potential best-in-class treatment",
          "position": 1,
          "objective": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients",
          "confidence": 0.6,
          "extraction": {
            "at": "2026-07-16 22:26:50.017864+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": "doc-narrative-v1"
          }
        }
      ],
      "locked": true
    },
    {
      "page": 25,
      "type": "setup",
      "title": "The slide uses a process flow diagram to represent clinical trial cohorts and study design.",
      "function": "present_framework",
      "rawType": "roadmap",
      "block": null,
      "metadata": {
        "slideType": "roadmap",
        "slideTypeCanon": {
          "name": "Roadmap",
          "slug": "roadmap",
          "status": "active",
          "canonId": "019de52d-0a55-72bc-9b7b-a47ef109839c",
          "version": 1,
          "description": null
        },
        "function": "present_framework",
        "functionCanon": {
          "name": "Present framework",
          "slug": "present_framework",
          "status": "active",
          "canonId": "019de52d-1403-7667-9100-d2ac6709f750",
          "version": 1,
          "description": null
        },
        "density": "dense",
        "densityScore": 64,
        "componentCount": 6,
        "textChars": 363,
        "nDataPoints": 6,
        "notes": "The slide uses a process flow diagram to represent clinical trial cohorts and study design.",
        "elementsJson": null,
        "confidence": 0.95,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:49.88+00",
          "seconds": 3.01,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/25",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-25",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.15,
            "w": 0.35,
            "x": 0.07,
            "y": 0.685
          },
          "kind": "callout",
          "text": "Interim Clinical Data Expected in Q4, Including Data From Cohort 3",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Callout",
              "slug": "callout",
              "status": "active",
              "canonId": "019de52c-f8d3-761a-8953-7d37080de5e2",
              "version": 1,
              "description": "Highlighted callout box."
            },
            "tool": null,
            "subkind": {
              "name": "Primary callout",
              "slug": "primary",
              "status": "active",
              "canonId": "019de52c-fbd1-70eb-a9ce-8997f8674c1d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "primary",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c1840d1f-660f-44ff-a4fe-c8951c360fce",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.35,
            "w": 0.88,
            "x": 0.06,
            "y": 0.22
          },
          "kind": "diagram",
          "text": "Part 1 (IV) and Part 2 (SC) cohort progression",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Diagram",
              "slug": "diagram",
              "status": "active",
              "canonId": "019de52c-f9f0-734a-81de-15382ff28c65",
              "version": 1,
              "description": "Schematic or relational diagram."
            },
            "tool": null,
            "subkind": {
              "name": "Process flow",
              "slug": "process",
              "status": "active",
              "canonId": "019de52d-039c-718f-ad3a-efe9c4b3c838",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "process",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "ae8f1875-d9f8-4cc6-9d9c-e150ae76d4d5",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.2,
            "x": 0.68,
            "y": 0.65
          },
          "kind": "list",
          "text": "Key Inclusion Criteria: Classical HCU, Hcy >80, age >=12",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "25553946-975f-44d0-84eb-d13a3319d593",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.2,
            "w": 0.2,
            "x": 0.41,
            "y": 0.65
          },
          "kind": "list",
          "text": "Endpoints & Design: Safety, PK, Hcy reduction, 4 weekly doses",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "947a89e5-c76c-4094-ba2f-4ed6f94b9a33",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.03,
            "w": 0.25,
            "x": 0.02,
            "y": 0.95
          },
          "kind": "source-note",
          "text": "IV = intravenous; SC = subcutaneous; hcy = homocysteine",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Source note",
              "slug": "source-note",
              "status": "active",
              "canonId": "23484952-494b-4a5e-b1ad-550d0d70e948",
              "version": 1,
              "description": "Attribution / source / caveat placed at the slide footer. Numbered footnotes use attrs.numbered."
            },
            "tool": null,
            "subkind": null,
            "framework": null
          },
          "subkind": null,
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "c595c414-52c9-4de1-b083-0175ae0a59a2",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.1,
            "w": 0.8,
            "x": 0.06,
            "y": 0.05
          },
          "kind": "title",
          "text": "Phase 1/2 Clinical Trial to Generate Proof-of-Concept and Path to Pivotal Trial",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "7e86cd42-c761-4446-b126-74b72eb0b026",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [
        {
          "matchId": "5df9b9d5-5c79-4d52-be4b-db6d5e7f87eb",
          "evidence": "The slide outlines a sequential clinical trial design.",
          "framework": null,
          "confidence": 0.8,
          "extraction": {
            "at": "2026-05-02 12:27:49.88+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 25,
          "frameworkName": "process"
        }
      ],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 26,
      "type": "resolution",
      "function": "summarize",
      "rawType": "key_takeaways",
      "block": null,
      "metadata": {
        "slideType": "key_takeaways",
        "slideTypeCanon": {
          "name": "Key takeaways",
          "slug": "key_takeaways",
          "status": "active",
          "canonId": "019de52d-06e7-7674-a891-9f7de3b11b6d",
          "version": 1,
          "description": null
        },
        "function": "summarize",
        "functionCanon": {
          "name": "Summarize",
          "slug": "summarize",
          "status": "active",
          "canonId": "019de52d-1541-704f-b86f-bf7b75056373",
          "version": 1,
          "description": null
        },
        "density": "balanced",
        "densityScore": 38,
        "componentCount": 3,
        "textChars": 567,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:49.485+00",
          "seconds": 2.378,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/26",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-26",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.55,
            "w": 0.42,
            "x": 0.07,
            "y": 0.212
          },
          "kind": "list",
          "text": "Preparing for Rapid Transition to Ph 3: Data from cohorts 1-3 may be sufficient for discussions with FDA on pivotal trial design; Manufacturing at commercial scale; Stable, high-concentration liquid formulation; Orphan and Rare Pediatric Disease designations",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.485+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "01085d22-39e1-45fe-bf8f-8ce090b385c1",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.55,
            "w": 0.42,
            "x": 0.51,
            "y": 0.212
          },
          "kind": "list",
          "text": "Addressing an Unmet Need While Focusing on Patient Convenience: Efficacy: Cohort 1 showed reduction in tHcy levels; Safety: large dosing window with acceptable AE profile; Potential for convenience of a single once-weekly injection at home",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "List",
              "slug": "list",
              "status": "active",
              "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2",
              "version": 1,
              "description": "Bullet or numbered list."
            },
            "tool": null,
            "subkind": {
              "name": "Bullet list",
              "slug": "bullet",
              "status": "active",
              "canonId": "019de52c-fc98-7169-a083-5cab805076ca",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "bullet",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.485+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "744aa413-a972-43f4-86c2-4966b7060e7c",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.08,
            "w": 0.88,
            "x": 0.06,
            "y": 0.04
          },
          "kind": "title",
          "text": "Advancing a Potential Best-in-Class Therapy for Classical HCU Patients",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.485+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "5c3bf5e1-4435-4423-92f4-733fd18bdd22",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 27,
      "type": "setup",
      "function": "state_next_steps",
      "rawType": "closing_ask",
      "block": null,
      "metadata": {
        "slideType": "closing_ask",
        "slideTypeCanon": {
          "name": "Closing ask",
          "slug": "closing_ask",
          "status": "active",
          "canonId": "019de52d-0aa4-750f-8aa1-8d622dd99f5c",
          "version": 1,
          "description": null
        },
        "function": "state_next_steps",
        "functionCanon": {
          "name": "State next steps",
          "slug": "state_next_steps",
          "status": "active",
          "canonId": "019de52d-14ca-70ac-b534-971f458cdf29",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 2,
        "componentCount": 2,
        "textChars": 3,
        "nDataPoints": 0,
        "notes": null,
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:51.442+00",
          "seconds": 4.316,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/27",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-27",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 1,
            "w": 1,
            "x": 0,
            "y": 0
          },
          "kind": "image",
          "text": null,
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Photo",
              "slug": "photo",
              "status": "active",
              "canonId": "019de52c-fd37-757f-b4a8-ca26d4888875",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "photo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.442+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "798f5bb0-c464-4bb6-af70-7bef7794dfed",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.05,
            "w": 0.08,
            "x": 0.083,
            "y": 0.765
          },
          "kind": "title",
          "text": "Q&A",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Title",
              "slug": "title",
              "status": "active",
              "canonId": "019de52c-f7dd-76d9-b848-b1f12bd85cf4",
              "version": 1,
              "description": "Slide title or headline."
            },
            "tool": null,
            "subkind": {
              "name": "Headline",
              "slug": "headline",
              "status": "active",
              "canonId": "019de52c-fae1-7463-9a7c-d60668eced0d",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "headline",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:51.442+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "b0145882-1e5a-4aa3-b7e9-07afd71df9c5",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    },
    {
      "page": 28,
      "type": "setup",
      "title": "This is a standard corporate cover slide featuring the company logo and address.",
      "function": "front_matter",
      "rawType": "cover",
      "block": null,
      "metadata": {
        "slideType": "cover",
        "slideTypeCanon": {
          "name": "Cover",
          "slug": "cover",
          "status": "active",
          "canonId": "019de52d-05f2-729d-9f93-e0504f0a2410",
          "version": 1,
          "description": null
        },
        "function": "front_matter",
        "functionCanon": {
          "name": "Front matter",
          "slug": "front_matter",
          "status": "active",
          "canonId": "019de52d-133d-73f0-9e26-201eda96b098",
          "version": 1,
          "description": null
        },
        "density": "sparse",
        "densityScore": 6,
        "componentCount": 2,
        "textChars": 65,
        "nDataPoints": 0,
        "notes": "This is a standard corporate cover slide featuring the company logo and address.",
        "elementsJson": null,
        "confidence": 1,
        "extraction": {
          "model": "google/gemini-3.1-flash-lite-preview-20260303",
          "runId": null,
          "at": "2026-05-02 12:27:49.273+00",
          "seconds": 2.09,
          "promptVersion": "v2-canon-conditioned"
        }
      },
      "links": {
        "slide": "/slides/019de073-9e32-71bd-acba-301a2d9cbf00/28",
        "deck": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00",
        "deckAnchor": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00#slide-28",
        "deckJson": "/decks/019de073-9e32-71bd-acba-301a2d9cbf00.json"
      },
      "components": [
        {
          "bbox": {
            "h": 0.065,
            "w": 0.115,
            "x": 0.088,
            "y": 0.188
          },
          "kind": "image",
          "text": "aeglea",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Image",
              "slug": "image",
              "status": "active",
              "canonId": "019de52c-f978-701f-a720-51d029d769e7",
              "version": 1,
              "description": "Photo, illustration, screenshot or icon."
            },
            "tool": null,
            "subkind": {
              "name": "Logo",
              "slug": "logo",
              "status": "active",
              "canonId": "019de52c-fdaf-743d-94c4-d7c6a0e55302",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "logo",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.273+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "87a97e00-dfee-4505-bb8d-c3993dd6329e",
          "parentComponentId": null
        },
        {
          "bbox": {
            "h": 0.015,
            "w": 0.346,
            "x": 0.088,
            "y": 0.463
          },
          "kind": "paragraph",
          "text": "805 Las Cimas Parkway Suite 100 Austin, TX 78746 aeglea.com",
          "attrs": null,
          "canon": {
            "kind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "5f2affc0-941d-4d07-959d-4bfc1930cea4",
              "version": 1,
              "description": "Single prose block in the body of a slide."
            },
            "tool": null,
            "subkind": {
              "name": "Paragraph",
              "slug": "paragraph",
              "status": "active",
              "canonId": "019de52c-fb80-75af-aa5c-a7a4bfac2433",
              "version": 1,
              "description": null
            },
            "framework": null
          },
          "subkind": "paragraph",
          "groupRole": null,
          "confidence": null,
          "extraction": {
            "at": "2026-05-02 12:27:49.273+00",
            "model": "google/gemini-3.1-flash-lite-preview-20260303",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "componentId": "5fc7e8b0-dd99-44ce-98a1-8662b56ecc64",
          "parentComponentId": null
        }
      ],
      "metrics": [],
      "tools": [
        {
          "tool": {
            "name": "Slide recipe: Cover",
            "slug": "cover-slide",
            "status": "active",
            "bestFor": null,
            "canonId": "019df269-2a08-767d-9128-e7431e6fe8a3",
            "version": 1,
            "bodyDocId": "019df269-29e5-7738-b5fa-6892e5dc8e65",
            "description": "The first ten seconds. Build it deliberately.",
            "familyLabel": "slide-recipe",
            "categoryName": "Slide",
            "categorySlug": "slide"
          },
          "agent": "designer",
          "layer": "slide",
          "agents": [
            "designer"
          ],
          "matchId": "cbc2742e-5bf2-4248-82d5-523a5f68db01",
          "evidence": "805 Las Cimas Parkway Suite 100 Austin, TX 78746 aeglea.com",
          "pageRefs": null,
          "priority": null,
          "whenToUse": null,
          "confidence": 0.9,
          "extraction": {
            "at": "2026-07-17 00:11:35.097256+00",
            "model": "or:meta-llama/llama-4-scout",
            "runId": null,
            "seconds": null,
            "promptVersion": null
          },
          "pageNumber": 28,
          "whyItWorks": null,
          "antipattern": null,
          "cardinality": null,
          "narrativePurpose": null
        }
      ],
      "frameworks": [],
      "arcBeats": [],
      "loops": [],
      "locked": true
    }
  ],
  "arcBeats": [
    {
      "from": 7,
      "to": 10,
      "label": "Problem (Identify pain)",
      "description": "Slides 7-10 provide an overview of Classical HCU, its clinical severity, and current clinical guidelines"
    },
    {
      "from": 11,
      "to": 14,
      "label": "Agitate (Make it worse)",
      "description": "Slides 11-14 highlight the diagnostic delay, risk of misdiagnosis, and current management limitations"
    },
    {
      "from": 20,
      "to": 24,
      "label": "Solution (Provide relief)",
      "description": "Slides 20-24 introduce Pegtarviliase as a potential best-in-class treatment and provide an overview of its innovative approach"
    }
  ],
  "loops": [
    {
      "from": 11,
      "to": 14,
      "label": "Cost Of Inaction",
      "description": "Highlight the cost of inaction for Classical HCU patients"
    },
    {
      "from": 20,
      "to": 24,
      "label": "Jobs To Be Done",
      "description": "Introduce Pegtarviliase as a solution to address the needs of Classical HCU patients"
    }
  ]
}