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Motor/Gait: ataxia, apraxia, and pyramidal dysfunction (spasticity). Parkinsonism: resting tremor, rigidity, bradykinesia, and postural instability. 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Diagnosis: Genetic screening for CSF1R mutations, clinical criteria have low specificity.", "attrs": null, "canon": { "kind": { "name": "List", "slug": "list", "status": "active", "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2", "version": 1, "description": "Bullet or numbered list." }, "tool": null, "subkind": { "name": "Bullet list", "slug": "bullet", "status": "active", "canonId": "019de52c-fc98-7169-a083-5cab805076ca", "version": 1, "description": null }, "framework": null }, "subkind": "bullet", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 13:09:06.366+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "beb11093-f463-4bc7-933e-9a50b9e49307", "parentComponentId": null }, { "bbox": { "h": 0.2, "w": 0.45, "x": 0.52, "y": 0.62 }, "kind": "list", "text": "Treatment: No approved products and no experimental treatments. Treatment is mainly supportive, palliative care and symptom alleviation. Limited experience and inconclusive efficacy with hematopoietic stem-cell transplantation (HSCT).", "attrs": null, "canon": { "kind": { "name": "List", "slug": "list", "status": "active", "canonId": "019de52c-f94b-779b-a53b-fd4904a5f4d2", "version": 1, "description": "Bullet or numbered list." }, "tool": null, "subkind": { "name": "Bullet list", "slug": "bullet", "status": "active", "canonId": "019de52c-fc98-7169-a083-5cab805076ca", "version": 1, "description": null }, "framework": null }, "subkind": "bullet", "groupRole": null, "confidence": null, "extraction": { "at": "2026-05-02 13:09:06.366+00", "model": "google/gemini-3.1-flash-lite-preview-20260303", "runId": null, "seconds": null, "promptVersion": null }, "componentId": "d882606e-8f79-43e1-8bcc-eb37f87eab83", "parentComponentId": null }, { "bbox": { "h": 0.03, "w": 0.8, "x": 0.03, "y": 0.87 }, "kind": "source-note", "text": "Lakshmanan et al, Neurol Genet 2017; Hayer et al, Neurology 2018; Lynch et al. 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