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The first cell therapy programs;; which are now approved treatments;; have been transformative in treating certain types of blood cancers;; but those benefits have yet to translate to other types of cancer. Affini-T is aiming to bring cell therapy's benefits to solid tumors. \"The vast majority of tumors;; and the vast majority of lost lives;; is really due to solid tumors;;\" said Juergen Eckhardt;; the head of Leaps by Bayer;; which co-led Affini-T's financing round alongside Vida Ventures. \"The big killers are colon cancer;; lung cancer;; pancreatic cancer. For those;; we don't really have any good therapies available yet.\" The Seattle- and Boston-based startup is based on research by Juno Therapeutics cofounder and Fred Hutchinson Cancer Research Center immunologist Phil Greenberg. Juno was a cell therapy pioneer that was bought by Celgene in 2018 for $9 billion. Among a crowded and competitive space;; Affini-T stands apart by what it's targeting;; said Jak Knowles;; the CEO and cofounder of Affini-T. In particular;; the company is focused on two genetic mutations that are common across many types of cancer;; located on genes called KRAS and p53. \"These are foundational to how the cancer is growing;;\" he said. \"KRAS allows the cells to divide faster.\" Affini-T's approach is to edit a type of immune cell called T-cells;; that normally fight cancers and viruses;; to better recognize these mutations. When these edited T-cells see these specific mutations;; they then kill the cancerous cells. Affini-T is still in the earliest stages of research;; but hopes to have two treatments enter human testing next year. The plan is to run a study that recruits patients with a range of cancers;; including pancreatic;; lung;; and colorectal;; to see where the drug could be most effective. 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